The RECK gene is a relatively new discovered gene with important implications for cancer research. The research has been primarily concentrated on the human gene with the ultimate aim to identify the invasive characteristics. Up regulated RECK is linked to significantly prolonged survival rates in patients with severe forms of malignancies. RECK is normally expressed in all cells of the body and has an important role in the balance between destructive and constructive features of the extracellular matrix. The RECK protein is a membrane-bound glycoprotein that inhibit matrix metalloproteinases which has the function of breaking down the ECM. There is a significant correlation between RECK gene expression and the formation of new vessels, presumably via the mediation of VEGF which is an important and powerful inducer of angiogenesis.

To fulfill the climate target that EU and the Swedish government have decided to apply, it becomes increasingly important that the energy efficiency of existing buildings and making new buildings energy efficient as possible. Of Sweden?s total energy consumption in 2011 was 40% used by residential and service. Of the 40% of the energy consumption was 60% used for heating and domestic hot water. A report from year 2012 shows that one reason why the heating volume is so great could be due to underestimating on the energy consumption for the heating in the planning of the building.

During the spring semester 2012 Robin Westlund has accomplished ?Controlled interaction for more creative meetings - Summit Flexiwall? with the individual focus on social communication based on visual interaction in future office. The project was a part of the course Degree Project for degree of Bachelor of Science in Innovation and Design Engineering (MSGC12) which includes 22,5 ECTS Credits. The course is a part in the program Innovation and Design Engineering program within the Faculty of Technology and Science at Karlstad University.Assigner of the project was Moelven Eurowand AB with their head office in Örebro. The company manufactures and assembles entire room solutions for offices.

The aim of this thesis was to examine how role players experiences libraries and if the libraries are or can be an arena for activities that involves role play. A public library exists for everyone, but could nevertheless be viewed as a female sphere where women both borrow more books and visit the libraries program activities to a larger extent, compared to men. I asked the question whether men?s reason for choosing a different venue for information and culture was related to the libraries not being able to satisfy their needs. The theory of the thesis was Dorte Skot-Hansen, Casper Rasmussen Hvenegaard and Henrik Jochumsens model that states that the libraries can have four different functions and act as a venue for meetings, knowledge, inspiration and experiences.

The technical development is advancing at high speed and now the turn has come for the traditional paper to digitalize into the so called e-paper. The newspaper industry has started to investigate the future possibilities of publishing the traditional newspapers on e-paper. Today?s newspapers are mostly financed by advertisement incomes, which makes the advertisers important players, who must be taken into consideration at an introduction of the e-paper. Since the e-paper does not exist as a finished product in the market today, in this essay we look into what kind of functions or services that can attract advertisers to the e-paper on the basis of the experiences made with the breakthrough of the web-newspapers.

Effects of fishery closure on perch was detected as female perch was on average 5 cm longer in closed areas compared to non-closed areas. This could be a result of larger individuals surviving as an effect of reduced fishing. No effect was detected on the reproduction rate of YOY (young of the year) perch.A zooplankton survey revealed less amounts of the most important plankton groups for YOY perch in areas with failed reproduction, though the difference was statistically insignificant.The distribution of YOY perch and YOY/adult stickleback differed completely in this study with no area where the two species are both present. It is sketchy to draw any conclusions from this data but it remains a field for further investigation.The reproduction problem is concentrated to the outer parts of the archipelago which confirms previous studies of the geographic extension..

Laminitis has crippled horses through times and many cures have been used to treat it. Since the mechanism of the disease is yet not fully understood, treatments are only ways to alleviate the pain and at best, slow down the pathological process enough to make time for improvement. This paper is a retrospective study of 71 horses treated by a protocol at Hästsjukhuset Strömsholm. The protocol implies three visits at zero, five and fifteen weeks. At each the horse is evaluated and treated by a veterinarian.

AbstractThis is a thesis done in cooperation with the firm Somas and University of Karlstad. The project is an independent final examination part of the program in Innovation and DesignEngineering comprising 22.5 points, and performed by Mia Myrén Zreloff during spring term 2012. In parallel and collaboration, Fredrik Kjellin performs a similar job for the same company and with the same extent, but for the Program in Mechanical Engineering.The client and supervisor at the company have been Magnus Jansson and Anders Josefsson. At Karlstad University has technical supervisor been Hans Johansson, and in the design- and development process it was Monica Jakobsson. Examiner has been Fredrik Thuvander, professor in the Faculty of Technology and Science at Karlstad University.The mission has been to make a basis work for the company's own development and make a computational model to calculate, visualize and implement materials and other solutions in the manufacture of the company's ball valves.The project has undergone three major phases that included thorough study of the company, production, the problem and product.

This report describes a Bachelor thesis work in which a robotised laser welding cell has been modelled and simulated for the purpose of making a presentation movie. The report shows that the work has been concentrated on making the movie from the modelling phase through the recording of the movie and ending up with the editing of the final presentation movie. A pre-study was made prior the Bachelor thesis work. In the pre-study a literature study was conducted about measurement and calibration of a welding cell. Measurement of almost all equipment in the entire cell was also conducted in the pre-study.

The aim of this study is to illustrate conceptions held by librarians and library and information scientists about weeding practices of printed books in public libraries. The study has been carried out by performing a series of qualitative interviews with librarians and by study of earlier research relating to the subject of weeding. The results have been analysed by utilizing a textual analysis method called idea and ideology analysis using so called dimensions to analyse and structure the results. The results indicate that weeding at Swedish public libraries is carried out by a mixture of objective and subjective methods, with certain statistical elements. Weeding procedures mainly appears to be legitimized according to what one refers to as knowledge of the local community, although lack of lending are cited from time to time.

The public libraries were quick to adapt to the changes that the Internet brought on, and today library websites are an important part of the public library. To meet the needs of teens today, the library website could offer a range of contents to make it an attractive place on many levels; both the academic needs as well as social and recreational needs should be addressed.The aim of this thesis is to evaluate public library websites for teenagers in Sweden, and to examine how well the websites address the developmental tasks and needs that teenagers have. The method used is website evaluation, one quantitative and one qualitative. A total of 60 public library sites for teenagers were evaluated, using 11 criteria based on Havighursts developmental tasks. The quantitative evaluation measured how many functions each website had per criteria, and showed that the majority of the sites had one or two functions for most of the criteria.

This report presents thesis of Liisa Kokkonen in collaboration with Muovikilpi Oy.The project?s goal is to find a new construction for an existing lamp made of acrylic. Form and design retains and the manufacturing occurs at Muovikilpi Oy. The project contains the new construction and manufacturing of the lamp and also a proposition for a set with floor and wall lamp.  The paper gives an outline of acrylic as material and how it reacts with light.

 In this essay the aim was to investigate how the EU is trying to function as a democracy promoter in three particular countries, the so called candidate-countries Croatia, Macedonia and Turkey. The aim was also to analyze if there exist any differences in how the EU functions in these countries as a democracy promoter with a focus on how acts of democracy promotion is taken place. In order to fulfil the purpose of the essay two questions were addressed, how does the EU perform in promoting democracy in the three candidate-countries Croatia, Macedonia and Turkey? And also, is it possible to identify any differences in how the EU functions as a democracy promoter in those three countries?The method used to fulfil purpose and answering research-questions was qualitative text-analysis.  The results of the study were that the EU does perform in a number of ways to promote democracy in the three countries. The main differences are that the EU is using primarily political tools in Croatia and Macedonia which are channelized top-down and economic tools in Turkey channelized mainly top-down to promote democracy.

Inspired by how to sketch a light cone from a flashlight in a comic I wanted to create an armature carried only by its own light cone. To manage this challenge I sketched in an architectural and sculptural way, where I chose to ignore the function of the lamp as long as possible.As a result I developed an armature with a stunning shape, with an illusion that it was carried by its own light cone. It could be hanged on a wall, placed on a table, pushed against a ceiling or standing on the floor.Depending of its size the light cone from the light source lightens up the surface and draws attention to the otherwise forgotten wallpaper or the undisposed statue in the darkness of the city..

Research shows that people with burnout experience a high degree of impairments in a range of cognitive functions including memory, attention and concentration. The overall aim of the present study is to investigate whether there is a correlation between subjective estimates of cognition and cognitive performance with objective tests in people with burnout with a focus on working memory and executive functions. Three specific questions were addressed; First, what cognitive problems are described and to what degree? Second, is the performance of executive and working memory tests related to self-reported cognitive problems? Third, are the self-reported cognitive problems related to measures of psychological distress? The study included 77 patients, 65 women and 12 men, with a mean age of 43.48 years. The results show that patients with burnout perceive themselves as having significantly impaired cognition in everyday life, which is clearly evident on the basis of the self-assessment forms PRMQ and CFQ.