Duchenne Muscular Dystrophy (DMD) is a hereditary X-linked fatal disease that affects 1 in 3500 male births. It is the most common kind of muscular dystrophy in children and leads to death in the late teens or early 20s for many patients. The mdx mouse is a model of DMD that can be used to investigate experimental therapies. Overexpression of a glycosyltransferase, CT GalNAc, in mdx mice has been demonstrated to prevent the development of muscular dystrophy. Overexpression of another glycosyltransferase, LARGE, is currently being investigated as a treatment for another group of muscular dystrophies, the dystroglycanopathies. In this study, we overexpressed LARGE in mdx mice in order to investigate its effect on the development of muscular dystrophy.

The aim of this thesis is to ascertain if women are discriminated in the European Parliament, and if so, how it is expressed. Our hypothesis is that female members of the parliament suffer a kind of double discrimination. The European Parliament consists of roughly one third women, but nevertheless the discrimination does not end there. According to our hypothesis women do not have the same opportunity to influence as their male colleagues, hence the double discrimination.The results of this thesis show that women are discriminated, mainly by not gaining access to the European Union's important issues, whilst the female dominated issues are scheduled on late evening and at the end of a session week. Another unsatisfactory issue was that even though half of the reports were given by women, they only received one third of the references to their reports while men received two thirds of the references.

Syftet med undersökningen är att arbeta fram en modell för hur företag bör arbeta innan, under och efter en kris för att bevara sitt varumärke. Studien baseras på en kvalitativ undersökning där primärdata insamlats via intervjuer med sex experter inom området kriskommunikation. Ett abduktivt tillvägagångssätt har används då fokus växlat mellan empiri och teori, men där största fokus legat på empirin. Teorin har insamlats via litteraturstudie där vetenskapliga artiklar hämtats från olika databaser, såsom google scholar och ABI/inform. Slutsatsen genererar i ett verktyg i form av en modell som ger riktlinjer på hur företag kan arbeta innan en kris för att förebygga och förbereda. Den visar även på hur företag arbetar under en kris för att minimera skadan av den samt hur de på bästa sätt kan återhämta sig från den.

The aim of this issue is to study how Swedish public libraries deal with the principles of freedom of speech and freedom of information in connection with public use of the Internet. The authors intention has been to find out whether the public use of the Internet has caused ethical problems for library workers and how the libraries solve situations when they consider their principles violated by library users. The authors study the debate on the issue in a couple of Swedish library magazines published during the late 1990s and they also give a few examples from the USA during the same period. They study the ethical principles and directives for schools published by the Swedish Board of Education as they claim that many of the public library users are students who bring along their ethical conceptions and thereby affect the ethical climate of the libraries. In their study the authors refer to ethical rules given to librarians by their trade union DIK and to the conclusions drawn from the hearing Good Ethics on the Net held by the Swedish IT Commission in 1998.

In a time of economic turmoil and financial crisis profitability matters rise higher and higher on company agendas. Many companies are pressured to find profitability to avoid layoffs or even bankruptcy. Profitability essentially depends on the margin on the product or service sold and the costs associated with selling these products or services and hence these areas are of vital importance if companies are to improve profitability. Previous research has focused, for the most part, on product profitability while customer profitability has received less attention. This study is based on a case study of a Swedish publishing house and aims to investigate how the company?s Cost-to-Serve varies between its distribution channels.

What traces of their actions are the Building Corporations in Sweden leaving in their archives and are they followingsome archival policies? This thesis is trying to answer that question. For that reason 25 archives fromSwedish Building Corporations have been investigated concerning their size, contents and age. Furthermore apoll performed by the Swedish National Archives in cooperation with the Swedish Employers? Confederationhas been analyzed.

Here I study some European films from the late 1950?s and the early 1960?s by directors like Fellini, Visconti, Pasolini and Godard. By comparing them with different sociological studies on the subject of female prostitution I try to find out if these films are interested in the actual situation of the prostitute, or in their own image of the phenomenon. Is she an object used for sex or just an sex object? Is she positively or negatively pictured? With realism or as a stereotype? Which aspects of her situation is shown and which ones are concealed? What is the view on the men who actually use her services?It seems natural that different types of films, with different types of prostitutes, illustrates different aspects of what prostitution might be.

The aim of this Masters thesis is to examine how identity formation is described in a few Swedish youth novels written in the 21^st century. We apply the theories of the psychiatrist Jan Ramström and the sociologist Anthony Giddens who both assume that identity is formed in relation to the environment. Ramström stresses that adults have an important role to play in the integration of the adolescents into the adult society. Giddens stresses that people in the late modernity are affected in their identity formations because of the loss of traditions. In order to find out how identity is formed, four main questions were constructed.

In this essay the author has chosen to analyze the similarities and differences between some of the northern Europe?s late Mesolithic and Neolithic cultures. The research is of a processual standpoint and the information is mainly gathered from secondary sources as well as ethnological studies. The material collected has been analyzed in both a processual and a post-processual manner to most accurately study the foundations of the three primary theories describing the Pitted Ware Culture?s origin.

Cultivation of grapevine is novel under Scandinavian conditions. We studied the impact of ground cover on frost hardiness of grapevine cultivars in Northwestern Scania in a two-factorial trial with four cultivars Solaris, Pinot Gris, Siegerrebe, Ortega and three kinds of ground cover (open soil, plastic cover and gravel). The study was conducted in a grapevine orchard, planted in May 2009, in Broddarp on Bjärepenisula Sweden (N latitude 56°; longitude E 12°). Soil and air temperature were monitored continuously. Frost hardiness measurements were performed every second week from late September to early December 2009. Frost resistance, LT50, was determined by electrolyte leakage measurement of the upper stems after artificial freezing at -15 °C.

Turkey has often been described as a cultural and geographical bridge between West and East. When the Islamic AKP came to power in Turkey 2002 many critics feared that the country was going to abandon its former Western allies and strengthen their relations with the Arab world instead. The criticism was intensified when the AKP increased Turkey?s bilateral relations with the Middle East and moved closer to former foe?s like Iran and Syria, at the same time as their long-time friendship with Israel experienced serious crisis. The aim and purpose of this thesis is to describe and explain the change in AKP?s foreign policy towards Israel.The research method is a combination of a qualitative text analysis of Turkey?s speeches in the UN General debate and Jakob Gustavsson?s model for explaining foreign policy change.The results show that the Turkish-Israeli relations have deteriorated after the Israeli attack on the Gaza Freedom Flotilla in 2010, particularly regarding diplomatic relations and military agreements.

This thesis describes how the punk movement was started in Sweden and how it continued to grow in the late 70's. The main questions are: How was the punk movement regarded in Sweden?; How did punk reflect the society? and What does the term punk represent?The study is based on journalistic texts in newspapers and magazines from the period of the breakthrough of punk. The work is based on a methodical review of the material and is organized thematically under topics like opinions, gigs, clothing and music. Initially, punk lead to misunderstandings and misperceptions since few people knew what punk was all about.

This report aims to suggest recommendations that will increase the efficien¬cy in theconstruction process of a construction project. Through interviews, studies of budgetcalculations and examples given by the project management at the construction sightsan understanding of some complications have been gained. These complications havebeen tracked back in an attempt to find the source of the problem, and at the end ofthe report some suggestions have been presented with the pur-pose of preventingthese complications. Through the interviews it is suggested that many complications re-late to lack ofcommunication and motivation due to poor planning be-fore and during theconstruction process, a suggestion that is supported by the study of the budgetcalculations. The examples from the project management also points out someshortages in planning, but also coordi-nation related complications due to lack ofcommunication. To prevent these problems the recommendations suggested at the end of thisreport aims to improve the planning process through a properly fulfilledwalkthrough-planning of all of the construction activi¬ties during the time needed todo so. It is also suggested that the company uses experience from previous projects inorder to reduce costs, and that the qualifications of the employees is being appliedwhere it is needed.

The issue of honour related problems in schools are important social problems in Sweden. It?s not unusual that honour related problem has had serious consequences before any action has been inserted by society. Sometimes the efforts made by society have had no impact whatsoever due to them being inserted too late. We can conclude based on our literature and our interviews, the importance of prevention.

The Swedish society woke up Boxing Day 2004 to the greatest disaster in modern times. As a result of a strong earthquake in the Indian Ocean tsunamis occurred that devastated resorts where thousands of Swedes were. In the disasters tracks were uncovered government paralysis and shortcomings of the systems control. The purpose of this study is to examine the capacity and means to demand accountability of politicians and officials of the Swedish political system. Extensive studies and the report from the commission of disasters will form the basis for the study.