The aim of this master thesis was to examine a possible connection between chromatin functions and the DNA damage repair system, with the imprinted IGF2/H19 locus as a bait. Interactions can occur within and between chromosomes and it has been shown that H19 ICR on both alleles can communicate with alleles on other chromosomes. The methylation-sensitive insulator protein CTCF is bound on the maternal H19 ICR and acts as an insulator by blocking the IGF2 promoter to access its enhancers. This is possible by formation of loop structures by CTCF that enables intra and inter-chromosomal interactions. CTCF is poly(ADP-ribosyl)ated by PARP-1 when it is bound to H19 ICR.

The Intensive Care Unit (ICU) is a special unit for patients who is in the need for emergency life-sustaining measures and every patient has complex medical- technical equipment. The experiences of a critical illness and the needs of critical care are experienced in different ways. The purpose of this study was to describe the experiences from patients in the ICU and how this experience has an influence on the patients. The method was a study of literature with a qualitative inception based on eight scientific articles and the analysis of content has been inspired by Graneheim and Lundman (2003). The result of the study is presented by four categories: to loose the ability to make themselves understood, to be forced to adjust to the environment of caring, to have the lack of connection with reality and to be in an intensive care environment, The results showed that patients in the ICU are affected by the attitude from the staff, the equipment around them as well as the sounds and lights in the environment there.

The aim of thesis was to, through a action research study and through individual interviews with five students, clarify their perspective on educational assistance in high school. The study shows that students prefer teaching in small groups outside of regular whole class because it gives the them access to the factors they consider crucial for a functioning support-time whit a skilled and dedicated teatcher, in a calm and safe environment. Moreover, the students claim the importance of technical equipment especially in the Swedish subject, but also in other subjects. Today the educational assistance varies from an outside-the-class teaching situation to a whole-class situation with teacher support as well as technicaal equipment. When the student were asked to describe the cinditions under which studies can be conducted with the whole class they tried to imitate the learning environment they have in a small group.

Avyttringen och ombildningen av kommunala och privata bostadshyresfastigheter till bostadsrättsföreningar har blivit ett allt vanligare fenomen under de senaste decennierna. Främst sker avyttringen i Stockholms kommun. Syftet med denna uppsats är att mäta om prissättningen vid utförsäljning av bostadshyresfastigheter inom Stockholms kommun skiljer sig beroende på om säljaren varit privat eller ett allmännyttigt kommunalt bolag. För att undersöka detta har olika regressionsmodeller applicerats på data över fastighetsprisregistret under två mandatperioder. Resultatet visar en tydlig prisskillnad mellan kommunala avyttringar och privata inom samma områdesindelning.

The technology used in the development of web-applications is evolving at such rate that it has become more and more important to keep web-applications modern. If an application is based on a technical platform that is not renewed, the platform may over time develop into an obstacle in further development of the application. There may be compatibility issues and some of the code may be unnecessary due to abstraction, and therefore more time consuming to work with. Sometimes the reason may be that an application has been built to run, and is running on an application server that is no longer being maintained. The system can be large and modernization can cost a lot.

The water tower in Uppsala city forest was built in the late 1950's in what is now a nature reserve. The unique place was supposed to be visited by people, which is currently not the situation. This bachelor thesis aimed to perform an analysis and make a design proposal for the environment surrounding the water tower. The analysis was performed using the methodology previously described by architect Arne Branzell. The methodology focuses on how a space is perceived by a person moving through it.

Syftet med denna studie är att titta på det vi vet om dopamins roll i aptitreglering idag, både generellt och med ett veterinärmedicinskt intresse specifikt på hund. Dopamin är transmittorsubstans i flera nervbanor i hjärnan och dess frisättning har traditionellt kopplats starkt till att positivt förstärka nyttosamma upplevelser eller handlingar i det som kallas kroppens ?belöningssystem?. I relation till föda och födorelaterade beteenden har man dock på senare tid sett att dopamin har en bredare betydelse än att enbart förstärka själva födointaget. I litteraturen syns därför ett fokusskifte mot ett vidare perspektiv med hänsyn till dopamins alla, nu kända roller ? något som väckt insikten om det dopaminerga systemets komplexitet och frågan om det ens är möjligt att få en helhetsbild över alla dess funktioner. Denna litteraturstudie har undersökt delar av ett stort litteraturmaterial fram tills idag och konkluderar att trots mycket forskning är dopamins exakta funktioner i aptitregleringen fortfarande inte klarlagda utan det verkar fortfarande råda ovisshet och oenigheter.

Within the framework of the concept of Network Based Defence (NBF) services should be available in the network, in order to increase the aggregate capacity. A common situation picture is one of these services.The aim of this paper is to answer the problem "What are the main problem areas in the creation of a situation picture in the land arena, with the help of the technical sensors that exist today?" and to develop a basis for continued research in the field situation in the concept Networking Enabled Command, Control and Collaboration (NEC3) at JCDEC (Joint Concept Development and Experimentation Centre). To answer the problem, a descriptive method is to be used in descriptions of the land arena, the information arena and the sensors and a deductive method is used when analyzing the asensors in the land arena.The problems that exist in the creation of a common situation picture, is that different types of obstacles makes it difficult for the sensors, the large number of people who are not combatants and that it is difficult to judge if a civilian vehicle is a threat, then it could be driven by civilians or by combatants..

The purpose of this article is to explore the technologies of government that are created within gender disorder assessments as an institution. I have done so by utilizing Norman Faircloughs discourse analysing instrument ?communicative action?, which focus on the social institution as relational.The material is strategically chosen by gathering texts from the Swedish state, the psychiatric clinics, NGO:s and by performing interviews with transsexual patients.When analysing the communication of the main agents, I have concluded that practices highly are a result of repeating text and speech inside the institution. The psychiatric assessments can also be seen as an illustration in changes in how citizens are governed in advanced liberal societies, where the role of the state has been gradually reduced in favour of other agents.I consider that the change illustrates an ?acting at a distance?-mentality where the patient is introduced to participate in the definition of the care in what I call ?negotiation as a technology?.

The aim of this study is to examine the roles of the children?s librarian in a reading aloud context. To reach understanding in this subject, we have conducted interviews with four Swedish librarians working in public libraries whom are involved with reading aloud practices. Previous research shows that the reasons for reading aloud in libraries are diverse and plentiful. Such reasons can be to spread cultural experiences, help children develop their language skills and promote the library to the public.

This work covers a broad analysis of the risks that could impact the achievement of electrical safety of electrical installations. The work includes both electrical equipment such as the installation of electrical equipment.The report illustrates the main technical characteristics of electrical connections greater than 10 mm2 and provides an introduction to the crimping systems for copper and aluminum conductors. In addition to that analyzes the factors that are important to assure the quality of an electrical connection throughout the value stream in terms of both materials such informations. Furthermore analyzed deeper the need for skills development of technicians and other staff.The different parts of this work are analyzed and presented, in theory to studies carried out both at Elpress AB and partly with the help of other scientific reports dealing with similar subjects. In addition, presents a survey that will help understanding the current perception of the electrical connections and cable crimping systems among end users.

Intelligent IT-based solutions, often called Smart Grids, are considered to be the future balancers of renewable energy sources. One area within the Smart Grid concept is called demand response, which is focused on making customers more consumption flexible by making them more active in their consumption. In this thesis the aim is to analyze a business model by investigating the income potential for a demand response solution as well as its market potential. This has been done through literature studies, interviews and development of a computational model.The use of 5000 households with flexible consumption can provide a cost reduction of 17.2% or 2.4 million SEK for a balance responsible party during an average year. If the solution is used to make strategic bids on the regulation markets the study indicates that the largest potential for revenues lies within this strategy.

Today evidence exist that environmental chemicals deteriorate male sperm quality and that testicular cancer is increasing. Bisphenol A (BPA) is a chemical with estrogenic effects used in the manufacture of polycarbonate plastic and are found in, for instance, plastic boxes, feeding bottles and food containers. Much of the research on how men's reproductive ability is influenced are performed on rats. This review article complies how male rat reproduction is affected by BPA as a model for humans. Studies have investigated how sperm are affected, hormonal changes during reproduction and how reactive oxygen species (ROS) affects sperm.

While designing an intranet for people with mobile work there are things you have to consider. This thesis is aim to bring understanding to the difficulties involved in these kinds of situations. Our focus is to develop ideas that motivate the assistants to use the intranet. We have looked into the profession of personal assistants and wish to highlight their problems to access the intranet. And we will as well demonstrate their needs for communication.

The purpose of the study is to examine what effects the law has on principals? approaches to mandatory reporting of child maltreatment (Social Services Act 14:1§). Moreover, the aim is to study if the regulation gets the impact intended. To respond to the purpose, legal science methods in the form of sociology of law were employed aided by qualitative semi-structured research interviews. The interviews comprised six principals in six different schools in the Stockholm area.