Bensimidazoler är en flitigt använd bredspektrumverkande substansgrupp antiparasitmedel. I Sverige finns det fem substanser (albendazol, febantel, fenbendazol, flubendazol och oxfendazol) som används inom veterinärmedicinen, varav en är en pro-bensimidazol (febantel). Däremot finns endast en substans tillgänglig inom humanmedicinen (mebendazol). Syftet med detta arbete är att reda ut skillnader och likheter mellan dessa substanser. Fokus ligger på kemisk struktur, kinetik, aktivitet, spektrum samt resistensläget i Sverige. Kemiskt sett är bensimidazoler relativt lika varandra då enbart substitutet (d.v.s.

Working as a veterinary nurse includes advising animal owners, helping them to make discisions through well-based facts and experience. Preemptive spaying of the healthy bitch brings many advantages and disadvantages. It leads to cessation of gonadal hormone production, and how the exact extent the surgery affects the dog is not yet fully understood. The sex hormones mainly control the reproductive system, but receptors of these hormones are found in many tissues of the body, and have complex relationships with other hormone systems. Spaying decreases the metabolism although the bitch gets an increased appetite, which enhance the risk of obesity, unless the owner restricts food intake.

The abrupt and early weaning of intensively kept lambs may have serious animal welfare implications, but relatively little is known about this. Weaning includes the breaking of the mother-young bond and abrupt replacement of milk by solid food, often coinciding with changes in the (social) environment. Altogether, these changes are likely to affect lamb welfare significantly. This study aimed to establish how strong and persistent lamb welfare is impaired following abrupt weaning by means of measuring behaviour parameters indicative of affective state. Also, we investigated the existence of a diurnal rhythm in play behaviour, which is considered an important indicator of positive affect and good welfare.

This study was conducted at the University of Bath, UK, from September to December 2014 as part of an ongoing research project aimed at elucidating how the Grb10 gene might act as a mediator of long-term health effects (such as predisposition to obesity, diabetes, coronary heart disease and hypertension) caused by environmental factors during development. This phenomenon is known as developmental programming. The purpose of this thesis was not primarily to answer any of the broader questions posed by this research project at large since this would require much more data than is reasonable to acquire over the course of a few months, but rather to evaluate the methods used in this project and reveal whether they are working the way they are presumed to. In the research project, which employs mice with the Grb10 gene knocked out as well as wild-type control mice, a dietary restriction model is utilized during gestation, which is supposed to generate offspring with lower birth weight and subsequent detrimental health effects in adulthood. This is supposed to be achieved by restricting the protein content of the pregnant mothers? diet to 9 % (as opposed to the control diet of 20 %) throughout gestation.

Stereotypier och tvångsbeteenden är relativt vanligt förekommande hos hundar. Exempel på några av dessa beteenden är flanksugning, filtsugning, slickdermatit, bita i luften, svansjakt och att stå som fastfrusen. Det finns oenigheter inom litteraturen om vad en stereotypi respektive ett tvångsbeteende är. Vissa författare använder begreppen som synonymer, medan andra ser det som två skilda beteenden. På grund av den rådande begreppsförvirringen använder jag termen avvikande repetitiva beteenden som ett samlingsnamn.

The mouse (Mus musculus) is the most commonly used mammal in biomedical research and can easily be restrained by both hand and by a device. Restraining animals causes stress that not only decreases the animal?s wellbeing, but may also influence the research results. The first aim of this study was to train mice to voluntarily stand still using positive reinforcement training. Another benefit of teaching a mouse to stand still is that you can avoid anaesthesia for some procedures.