Tumour development occurs to a large extent because of dysregulation of the cell cycle. Of particular importance are defects occurring in the G1 phase. The reason why G1 is critical is because of the influence of several signals (external signals as well as cyclins and cdks) on this stage. The G1 phase can be divided into two parts, G1pm and G1ps. Each part has its ?own? restriction point which needs to be passed in order to progress to S phase.

The world is currently facing a huge severe challenge in handling the issue of climate change. One of the ways to lower the green house gas emissions, which is seen as one of the main contributor to the climate crisis, is to use renewable technologies such as for example photovoltaic (PV) systems. PV-systems are also suitable for so called micro production, small scale energy production facilities, since it can be placed on practically any rooftop with the right solar conditions. In Sweden the usage of PV-systems has not yet gotten any wider spreading, even though the solar radiation conditions are very similar to countries that produce a lot of solar energy, as for example Germany. The aim of this paper is to describe non-adopter perceptions of PV-systems. The study holds a qualitative approach using deep interviews for data collection.

Detta arbete behandlar problemområdet systemförvaltning och är en vidareutveckling av förvaltningsmodellen vid systemförvaltningsprocessen. Vid systemförvaltningsarbetet finns det olika förvaltningsmodeller som kan vara ett stöd vid taktisk och operativ styrning samt administrativ kontroll.Systemförvaltningsmodellen består generellt av sju olika rekommenderade delmodeller där bland annat systemförvaltningsprocessen ingår. Modeller för systemförvaltningsprocessen bör förenkla, effektivisera och ge stöd när systemförfrågningar samt systemkrav inkommer från verksamhetsledningen eller systemanvändaren. Undersökningen i detta examensarbete fokuserar på en vidareutveckling av modellen Application Maintenace Cycle (AM/Cycle) som utvecklats av Peder Brandt.Vidareutvecklingen i detta arbete resulterar i en modell för systemförvaltningsprocessen, vilken benämns Application Maintenace Schedule Cycle (AMS/Cycle). Litteraturstudier och intervjuer har påvisat vissa svagheter med modellen AM/Cycle, vilket tagits i beaktande vid vidareutvecklingen av AMS/Cycle.

The importance of energy- and environmental issues has increased, and the work towards reducing carbon dioxide emissions plays a major part. The European Union has set up goals for the membership countries to work towards this to happen. The carbon dioxide emissions in Sweden have been reduced the last few years, but there is still a lot to do. About 30 per cent of Sweden?s carbon dioxide emissions generate from energy usage related to housing, this is why the housing sector is of interest to examine.

We live in a stressful world and a demanding society where the ability to quickly adapt is one of the most important and most difficult challenges of today. A fairly new phenomenon called intranets has evolved to meet this challenge, however many examples of corporative intranets are stories about failures and systems with poor usability. This study focuses on how the user oriented approach to systems design affected upon a system development process of an Intranet, solely developed within a company, and how it impacts on the intranets popularity among the employees in the company. The study starts not from the literature but from a survey, which is based upon the Delphi method. Which results were used for further in-depth research about the subject, by interviewing three representatives from the company.

The purpose of this essay is to try to understand the relationship between the structures of modern working life and the development of burnout. By using the method of qualitative interviews we wanted to see if the Effort-Reward Imbalance Model could be applied to the data we had collected. Two questions have been highlighted in our research:        ? Is it possible to establish a relationship between the structures of modern working life and the development of burnout among the subjects interviewed?  ? Is it possible to explain the development of burnout among our interviewed subjects through the Effort-Reward Imbalance Model?    Our theoretical frames are the general theories of the modern society and the modern working life as developed by Anthony Giddens, Ulrich Beck and Zygmunt Bauman. We have also used Johannes Siegrist?s medical-sociological Effort-Reward Imbalance Model (ERI-Model).

Agencies towards Sustainable Development ? A Study of Environmental Management Systems in Governmental Agencies 2005A vision of the Swedish government is to build an ecologically sustainable society. A tool in this effort is to implement environmental management systems (EMS). The aim of the thesis is to present in which phase of the implementation of EMS Swedish governmental agencies are. This will be done by compilation and evaluation of agencies? yearly environmental reports.The thesis is written in co-operation with the Swedish Environmental Protection Agency (Swedish EPA).

Personal Life Coaching is a new profession in Sweden. A Personal Life Coach wants to empower his/her client to make changes, clarify needs and reach goals. A coach can also be just a pivotal human connection for dialogue. The need for coaching has grown due to the societal changes and unsure rules on the labourmarket. Personal Life Coaching lays the groundwork for competence development and good health..

The goal with this examination thesis is to investigate the difference in carbon dioxide emissions between a building with a wooden versus concrete carcassing from a life cycle perspective. The huge amounts of carbon dioxide released into air from human activities must be reduced to prevent serious consequences. A way to limit this issue is through performing a comparative study where the result shows which of two products with the same function has the lowest emission of carbon dioxide, whereof the product with the lowest carbon dioxide pollution can be chosen.To be able to perform a study like this an object has been chosen and studies about life cycle analyses have been done. The rental square meter, the thermal conductivity value, the energy requirements and the placement of the building has been set equal in both framework types. There were solely dissimilarities of the two buildings taken into account when this comparison study was performed.The result of the study is that a building constructed with a wooden carcassing has the lowest amount of carbon dioxide emissions.

Abstract Title: Total Cost of Ownership ? Revealing the true cost of owning and operating equipment. Authors: Anna Bladh Anna Ström Tutors: Michaela Boye, Parts and Service, PTD, Alfa Laval Göran Berg, Parts and Service, PTD, Alfa LavalCharlotta Johnsson, Department of Automatic Control, LTH, Lund UniversityBertil I. Nilsson, Department of Industrial Management and Logistics, LTH, Lund UniversityCarl-Henric Nilsson, Department of Business Administration, Lund University Core issue: ?Which costs should be included in a general Total Cost of Ownership model regarding centrifuges, and what input variables are needed in order to calculate those costs in a user-friendly way and with a maintained level of accuracy?? Purpose: The theoretical purpose of the thesis is to identify the cost items that have the greatest impact on a TCO calculation for a centrifuge.

Since the 1990s, when the number of transnational companies increased, it has created challenges regarding the responsibility of human rights. As a response to these challenges the United Nations Human Rights Council (UNHRC) unanimously endorsed the new policy UN Guiding Principles on Business and Human Rights (UNGP) in 2011. UNGP does not have the status av international law, yet simply as guidelines and its implementation is based on good will and voluntary efforts. Now, 10 years later, this study aims to get understanding regarding if UNGP is considered as norm by the Swedish Government, Volvo and Gothenburg Municipality. The material of the study consists of sustainability reports, annual reports and governmental documents with focus on human rights in relation to business published between the year of 2011, when UNGP was endorsed, until 2020.

This report is a thesis for collegeengineering program in structuralengineering at Uppsala University andwas commissioned by the Swedishcontractor Svevia. The study aims toprovide an overview of the mostbeneficial bridge material from bothenvironmental and economic point ofview.The life-cycle analysis covers onlycarbon dioxide emissions, since it isthe most spoken of in today?s climateagenda. Furthermore, this study aims tohighlight which parts, of the systemboundary, that contributes to greatercarbon emissions for the wood- and theconcrete bridge.The life-cycle cost analysis wascalculated with a lifespan of 40 yearsand covers the basic cost of investment,operating and maintenance, anddecommissioning costs.The analyzed constructions in this studyare existing projects that are almostcompleted. Both bridges were designed tohandle loads up to 60 tons.

In the literature it is not possible to find something about Swedish UN Military Observers (MO) experience of life is changing after their service. The aim of this study was to investigate if this has happened. The selection is of type ?snowball?. Interviews were made with twelve MO by telephone, both male and female.

The computer consultant company Create in Lund AB wishes to facilitate their invoice routines, as it at present is required that the administration finds and compares information from two different systems.The purpose of this thesis is to develop an invoice management system that simplifies the invoice management process for the administration at Create. During the development of the system, I have chosen to follow the software development process Unified Process and also tried to find design patterns that can be applied to the integration.The result of my project is a self-contained application developed using the Java programming language that communicates with the databases of the other two systems and presents relevant information to the user as a set of invoices. Of the 23 design patterns I studied, I used four of them in the invoice management system. However I couldn?t find any connection between any design pattern and the integration of systems.

Today many companies and municipalities requires that their suppliers should have an environmental management system to work by. This might be one of the reasons to the increasing number of companies that today are implementing environmental management systems. Care of Haus is one of the companies that thinks that the benefits are bigger than the disadvantages, when it comes to environmental management systems, therefore they have made the choice to work with ISO 14001.The ISO 14001 standard is deified on the PDCA- cycle. PDCA stands for Plan, do check and act. Care of Haus choose to work with the ISO 14001 standard since it is a well-known standard for the companies that?s Care of Haus collaborates with and it is also well-known within their clienteleWithin this report an environmental investigation has been made.