The process of drug discovery is very slow and expensive. There is a need for reliable in silico methods; however the performance of these methods differs.This work presents a targeted study on how the drug discovery methods used in OpenEye?s tools ROCS, EON and FRED perform on targets with small ligands. It was examined if 12 compounds (markers) somewhat similar to AMP could be detected by ROCS in a random data set comprised of 1000 compounds. It was also examined if EON could find any electrostatic similarities between the queries and the markers.

Political disenchantment and detachment is proven to be growing in well established democracies. This development brings along concerning behavior regarding general political participation. Fewer citizens participate in elections, parties are losing members, and the trust in politicians is steadily decreasing. IDEA (Institute for Democracy and Electoral Assistance) has been registering voter turnout worldwide for the last 60 years and their publications show a decline in voter participation since the 1980s.During the same period of time another development has caught attention, namely the fast progress of the medium Internet. The new generation of Internet functions is called Web 2.0 and allows users not only to create content, but also to interact with each other.This dissertation aims to explore the possibilities emerging when integrating Web 2.0 in political processes.

The purpose of this study is to examine young peoples' perception of their media criticial competence in relation to digital news. The study is based on quantitative research interviews with young people (15-17 years) and qualitative interviews with people in the same age group as well as teachers and international media professionals.This study's theoretical point of departure is McQuail´s observation that peoples' values and views to a great extent are influenced by the media. Another source of theoretical inspiration was Haberman's ideas about how a diversity of views and arguments increase the citizens' ability to reflect critically on social developments - maybe even more so than in societies with  independent media and "neutral" news.The study shows that the young generation of web based news consumers assumes that it is very important to be an aware and critical consumer but also that they do not feel sufficiently equipped with the right tools required to understand the long-term impact and effect of the media reporting online. Young people basically seemed to acquire their knowledge about media by doing and learning on their own. Surprisingly, according to the young people that were interviewed for this project, the schools seemed to play a secondary role in the development of their media critical capacity.

AbstractInterest in the subject appeared from real events. We seemed to discern a trend in society. Wehave noted that the amount of social enterprises to a greater extent is formed in Sweden.Companies like GodEl, Postkodslotteriet and DEM Collective are typical illustrations ofcompanies included in the category of social enterprise. It seemed as socially profiledcompanies is the new generation companies. The purpose of this essay is to make aninventory of possible competitive advantages that arise from social branding.

Wavecraft AB develops medical equipment for heating of organic synthesises. The heating is done with microwaves, which improves the process in both speed and accuracy compared to the more traditional methods where heating elements are used. This report discusses the developement of an automatic lid mechanism for one of Wavecraft's product prototypes. The company assumes that the final product will be integrated by customers into fully automated systems, and the upgrade from a manually to an automatically controlled lid is therefore an important step in the product's developement process.The first stage och the project was an idea generation process. The ideas generated here were organized into five different concepts of which the best one was selected through the use of a concept matrix.

När man som TV-tittare ser på sportprogram, kan man lätt förledas att tro att ?alla människor? tycker sport är viktigt, men så är det naturligtvis inte. Man kan dock anta att framställningar av medierad TV-sporten som fenomen, finns i de flesta människors föreställningsvärld. Utgångspunkten för den här uppsatsen är att placera in TV-sport i ett större sammanhang, där TV-sport kan ingå som en del av det som människor tar del av och som i viss mån inverkar på hur individer formar och skapar sin identitet. Den här uppsatsen handlar om hur kön (re-) presenteras genom TV-sport och hur detta kan ingå i vad som konstruerar en könsidentitet för en yngre generation av den kvinnliga TV-publiken.

EKHO - The Ecumenical Association for Christian LGBTQ people has existed in Swedensince the 1970's second half. The movement had its ups and downs throughout the years. Inthis essay, I will examine what happened when the movement was formed and how thefirst period developed. By examining EKHO Stockholm´s magazine EKHO-bladet my task isto describe the story from when the first EKHO association was formed until the EKHO organizations of Sweden joined together and formed the National Association, Riks EKHO. My second issue is to look into which role EKHO has played for the development in LGBTQ-issues for the Church of Sweden by analyzing documents from within the church concerning these matters.

This thesis is carried out on behalf of watermixer manufacturer Ostnor AB in Mora.The thesis deals with the area of Article Bound Instructions (ABI) at the company'sassembly department, regarding the layout and management routines involved withthese instructions.In the current situation there are problems with no uniformity in the manner in whichthe ABI is written, then referred to both the civil structure, images and specificityrates in the text.Another problem is that operators do not make use of the ABI that are available inthe current situation, and that there are no clear procedures for who has theresponsibility to write, update and change these ABI.During this work has several people that were identified as key personnel of thethesis held in order to get a handle on how the current situation of the variousobjects of the work looks like, and to examine different desires about the future ofthese should look like from the different subjects perspectives been interviewed.During the work, a number of deficiencies, including that the current program that isused to write the ABI, Lotus Notes, do not possess near the prerequisites for being asimple program to deal with when writing the ABI, which is a condition since wishesare about to put the responsibility for the ABI generation to the departmentsoperators, since their main task is to assemble and do not bother with a program in acomputer.The result of this work has generated new layout and structure of the ABI, designedto be used continuously in the assembly for evaluation, routines regardingresponsibility of the ABI for the Department of Production Engineering (PT),procedures for how the ABI should be written regarding amount of detaileddescriptions in the text and use of pictures.In addition, proposals for further work and improvements has been developed basedon experience during the work and presented at the end of the report..

How do young adult students communicate through their smartphones today? Which applications and features do they choose? What motivates their choices for the various possible situations? In this paper we investigate which communication channels young adult students in Sweden use for private message communication in their smartphones, in what way they use the channels and why they choose specific channels for different types of communication. In Sweden today, there are numerous of different ways of communicate through smartphones. We have interviewed ten Swedish young adult students regarding their use. The results speaks for that SMS has proven to still be used very frequently, even though it has existed for many years and that there are plenty of other ways to communicate through private messages today.

Jag blev under min utbildning introducerad i smidets värld och där är jag kvar. Jag har velat fördjupa mina kunskaper att smida tillsammans med barn men underlaget som finns är tunt. Jag har även märkt under mina VFU perioder att metalldelen i skolan inte får det utrymme som den förtjänar. Varpå syftet med mitt arbete har varit att ta reda på hur man kan belysa smidets kulturtradition, hur man kan arbeta med smidet i skolan och visa varför metallslöjden förtjänar större utrymme inom ämnet trä- och metallslöjd. Metoden för att söka svar på mina frågor består av litteraturstudier inom ämnet samt intervjuer med lärare i grundskolan som undervisar i smide.

The aim of this inquiry was to investigate the most appropriate measures to reduce noise impacts from road traffic on the Nydala recreational area in Umeå municipality due to the planned re-routing of the E4 motorway to an existing road along this area. The sound environment is an important part in the experience when we are visiting recreational areas. Noise is not only disturbing; the liberty from unwanted sounds also allows us to perceive natural sounds that are a benefit for the cultural experience. Therefore it is important to take actions to protect this well used area from traffic noise. The reasonable options to avoid noise impact in this case are to lower the speed limit, using a noise reducing coating or use noise protection screens and walls.

The purpose of our study was to examine how missing children are portrayed in media. We wanted to see if there are any recurring story patterns and characters in the texts. We also wanted to examine how the relationship between children and adults are framed and which comprehensive view of children is mediated in journalistic texts.Our questions were: how do Swedish newspapers write about missing children? Which narrative pattern are there in the texts? How are children and adults represented in the texts? What relationship between children and adults are made visible in the texts? What a comprehensive approach to children is constructed in the texts?For this study, we used the media discourse, theories of representation, stereotypes and characters. And theories of narrative, dramatic turns and opposites.We chose to make three case studies in which children suddenly disappeared, the case of Bobby Äikiä, the case of Engla Höglund and the case of Sebastian Hedman.

The aim of this essay is to investigate to which extent the novel Kvinnor och äppelträd by Moa Martinson can be classified as a polyphonic novel. The concept polyphony was established in literary theory by the Russian language theorist and literary critic Michail Bachtin in 1929, in his book Problems of Dostoevsky?s poetics. In order to understand and comprehend the concept of polyphony I have used an interpretation due to the literature scholar Robyn McCallum. She notes that the characters in a polyphonic novel function as focalizers.

Sweden is getting an aging population and with this comes an increase in neurodegenerative diseases such as Alzheimer?s disease (AD). Bilingualism is also on the rise and this may result in an increase of bilingual people suffering from AD. Due to the linguistic deterioration associated with the illness people with AD, bilingual and monolingual, will be an increasing patient group with speech and language pathologists (SLPs). Word retrieval difficulty is an early symptom of the disease and several strategies to compensate for this have been observed (e.g.

In a world where digital media is becoming a greater part of people?s everyday and working lives it is plausible to assume that the upcoming generation of pupils expect the teaching media to adapt thereafter. It is this assumption of an increased demand that Natur & Kultur is hoping to be able to meet. This thesis has been a stage in the process of producing digital material in the subject of mathematics for high school students. Specifically the aims of this thesis have been to make a rough description of the largest competitive companies? products within the same market, explore and put together a brief theoretical foundation of contemporary research and produce concrete examples of ideas for digital applications.