Animal welfare is impaired if the diet does not provide sufficient feeling of satiety or the ability to perform natural feeding behavior. Pigs are omnivores and spend most of the day searching for food by rooting, grazing and chewing. Both inability to perform foraging behavior and insufficient feeling of satiety often leads to direction of foraging behavior towards stereotyped and abnormal oral behavior. Dry sows are often fed restrictively which leads to unsatisfied feeling of hunger. Dietary fiber has been found to reduce stereotypic and abnormal behavior as well as aggression, which could indicate that pigs need to forage has been met giving a feeling of satiety.

Soybean meal from South America is the most common protein feed used for animal production in Sweden. Production of soybean has negative effects on the environment and the transports from South America to Sweden causes considerable CO2 emissions. Therefore it is a growing interest in locally produced protein feed in Sweden. Protein feeds that are possible to grow in Sweden are rapeseed, peas, faba beans and lupins. Those are adapted to the Nordic climate and are perfect to grow in cereal rotations.

Environmental chemicals are transported to the Arctic through the air and oceans, once within the Arctic they spread through rivers, lakes and other watercourses. Polar bears and sledge dogs in-gest high concentrations of environmental chemicals since many of the chemicals are fat-soluble and their diet mainly consists of marine mammals. The aim of this study is to describe how environmental chemicals spread in nature, how they reach the polar bears, and finally how they affect the animals reproduction, with reproductive hormones and genitals in focus. The animals are exposed to a cocktail effect which complicates the assessment of the chemicals impact on the reproduction. Studies show that the genitals can decrease in size or become malformed, sexual maturation can be affected and the reproductive hormones can be disturbed.

Syndecan-1 is a cell surface proteoglycan which participates in cell adhesion, differentiation, motility, morphogenesis and intracellular signaling. The two glycosaminoglycans heparan sulfate and chondroitin sulfate are covalently attached to the ectodomain of syndecan-1 via a tetra saccharide linkage sequence. However, the ectodomain can be modified having only one or neither of the glycosaminglycans attached. The glycosaminoglycans are capable of binding ligands such as fibroblast growth factors (FGFs) and support activation of receptors. The ectodomain is proteolytically cleaved from the cell surface by metalloproteinases in a process known as shedding.

Vectors based on lentivirus backbones have revolutionized our ability to transfer genesinto many cell types. Lentiviral vectors integrate into the chromatin of target cells and do not transfer any viral genes causing vector replication. Both of these features arecommonly used in gene therapy and have been used clinically in individuals sufferingfrom cancer, infections and genetic diseases. It has been discovered that T-cells can be genetically modified to be used as effective weapons against cancer: therefore virus mustbe produced to deliver the gene of interest into the T-cells. In this project, lentiviralvectors have been produced to transfer the gene coding for a chimeric antigen receptor(CAR) which is directed to CD19 on B-cells.

Gene technology has become more and more attractive in plant breeding during the last twenty years. This is probably because it can readily improve the existing commercial cultivars that have only one or a few drawbacks by modifying one or a few genes without changing the main genetic constitution. In this regard, gene technology is more effective than conventional breeding.The aim of this project was to analyze the fruit quality of the non-transgenic apple scion ?Jonagold? grafted on non-transgenic and rolB-transgenic apple rootstocks. The rootstocks used were M9-rolB1, M9-rolB2, M26-rolB and non-transgenic controls M9 and M26.

Background: Folate is a water - soluble vitamin necessary for normal DNA synthesis among  other mechanisms. Folate deficiency can cause megaloblastic anemia resulting from abnormal erythrocyte d evelopment. At the Department of Clinical Chemistry, Linköping, analysis of folate is performed with Siemens ADVIA Centaur® XP which uses an immunochemical method with chemiluminimetric detection. Currently, the assay is conducted on serum, is poured off and frozen after 48 h and treated with light protection because folate is considered to be light sensitive.Methods: This study tested lithium heparin plasma for analysis of folate with Siemens ADVIA Centaur® XP with the aim to be able to perform a package of analyzes in anemia investigation from the same collection tube. Furthermore, the stability of folate was studied for up to 168 h and examined regarding light sensitivity.Results: Statistically significant higher values were obtained in the analysis of folate in lithium heparin plasma than folate in serum (p < 0,001).

This literature research is meant to answer the following questions: ? What was the Swedes consumption of fat from 1935 to 2009? ? How has the fat consumption corresponded to the current recommendations? ? What is LCHF and which are the main advantages and disadvantages? Fat supplies us with energy, isolates and protect organs from bumps and punches. Fat is insoluble in water but soluble in organic solvents. The properties of a fat depend on its structure. The most common fat in human food is triacylglycerides.

As for today, a large quantity of protein feeds is imported from other countries to be used in the Swedish dairy production. The main import is soya from Brazil. The soya-production in Brazil results in negative consequences for the natural environment in the area, and the long transport of the feeds requires a lot of energy. The organic dairy production in Sweden is, with the highest probability going to be forced to use 100 % organic feed to the cows in the year 2005, due to new EU-rules. These are some of the causes why there are reasons to look closer at the possibilities to feed Swedish cows with only Swedish feeds. In this study, I have looked at the KRAV-rules for organic feeding, where the goal is feeding with only KRAV-approved feeds.

The present study discusses the metabolism of ethanol in the human body from the ingestion of ethanol to the excretion of its break down products water and carbon dioxide. Ethanol is a small molecule, soluble in water as well as in organic solutions. It is quickly distributed to every section in the body, where it exerts a direct toxic effect on the cells. Ethanol cannot directly leave the body efficiently so it needs other metabolic pathways. The molecule is metabolized by oxidation, predominately in the liver.

The purpose of this study was to investigate whether resistant maltodextrin is suitable as a fiber source in the probiotic fruit drink ProViva Mango without affecting the probiotic bacterium Lactobacillus plantarum 299v, viscosity or the sensory experience of the drink. Resistant maltodextrin is produced from hydrolyzed corn starch and is classified as a soluble dietary fiber. It is relatively resistant to digestion in the small intestine, where approximately 10% can be broken down, 50% can be fermented in the colon by the intestinal flora and 40 % is excreted in the faeces. Resistant maltodextrin has several important qualities when it comes to food processing. When added in a product, it does not affect the viscosity or taste and it is heat and acid stable.

Reducing the CO2-pollution, resulting from the combustion of fossil coal for energyproduction, is important to affect environmental changes. One way to achieve a reductionis to use the oxy-fuel technology. The technology uses O2 and re-circulated flue gasduring the combustion which results in a flue gas mainly consisting of CO2. The flue gascould then be compressed and stored without environmental effects. A problem thatfollows from the compression is the risk of acidification in sensitive parts of the process.Acidification can occur because of reactions following from the contact of condensedwater and sulphur- and nitrogen-oxides which are also present in the flue gas.This report compiles and evaluates the basis of a scientific unit with the purpose ofexploring the possibilities of extracting impurities of SOx and NOx from the flue gases.The dimensions of the unit are based on basic conditions, defined for an existing oxy-fuelprocess at Chalmers, and on the results of computer modelling.

Reducing the CO2-pollution, resulting from the combustion of fossil coal for energyproduction, is important to affect environmental changes. One way to achieve a reductionis to use the oxy-fuel technology. The technology uses O2 and re-circulated flue gasduring the combustion which results in a flue gas mainly consisting of CO2. The flue gascould then be compressed and stored without environmental effects. A problem thatfollows from the compression is the risk of acidification in sensitive parts of the process.Acidification can occur because of reactions following from the contact of condensedwater and sulphur- and nitrogen-oxides which are also present in the flue gas.This report compiles and evaluates the basis of a scientific unit with the purpose ofexploring the possibilities of extracting impurities of SOx and NOx from the flue gases.The dimensions of the unit are based on basic conditions, defined for an existing oxy-fuelprocess at Chalmers, and on the results of computer modelling.

Background: Sweden is a country where vitamin D deficiency seems to be common, partly because of its geographical position, which reduces the availability of UVB radiation, but also that people avoid sunlight due to increased skin cancer risk. Research shows that vitamin D plays an important role in the prevention of many diseases such as cancer as well as autoimmune and neuropsychiatric diseases.Vitamin D is a fat soluble pre-hormone and a collective name for closely related compounds which act as hormones after undergoing a transformation in the body.Humans can utilize vitamin D through diet and produce it in the body by exposing the skin to the sun. Previous observational studies and epidemiological studies have established a hypothesis that there seems to be an association between vitamin D supplementation and reduction of depressive symptoms.Objective: The aim of this study was to investigate if vitamin D supplements may decrease depressive symptoms.Methods: This work is organized as a literature review and article search is made in the database PubMed in January 2012. Keywords used were ?vitamin D and depression? and inclusion criteria were: randomized clinical trials, be conducted on humans, written in English.

Iron deficiency is one of the most frequent micronutrient deficiencies around the world. Low iron bioavailability simultaneously with a high iron requirement is a high risk factor for developing iron deficiency. Probiotics are microorganisms that confer a health benefit on the host. Prebiotics are oligosaccharides which provide a health benefit on the host due to a positive modulation of the microflora in the gut. The aim of this paper is to evaluate if there is a connection between pro-and/or prebiotics and iron bioavailability.