Feline infectious peritonitis (FIP) is a feline viral disease with high mortality. There is no cure or any effective vaccine available today. Many questions are yet to be answered about this disease and the immune response in affected cats. The aim of the study is to evaluate two different techniques for the study of cytokine profiles in cats vaccinated with a vaccine concept against FIPV. More information about the immune response in these cats could give valuable information to better understand the pathogenesis of the disease and the development of an effective vaccine.

Peritonitis is a potentially life-threatening disease in horses. With no published work from Sweden, the objective of the study was to describe the occurrence and demographics of horses with peritonitis and to evaluate the outcome of treatment in terms of short-term survival during a ten-year period in a large clinic in Sweden. Data were examined in a retrospective manner in 69 horses diagnosed with and treated for peritonitis at Universitetsdjursjukhuset (UDS) in Uppsala between 2002-2012. Demographic data examined included age, breed, gender, history, duration of illness before arriving at UDS, reason for seeking veterinary care, initial clinical findings (general state of health, heart rate, respiratory rate, mucous membrane appearance, rectal temperature, abdominal sounds, rectal examination, nasogastric tube results), abdominocentesis results (abdominal fluid analysis including visual inspection, leukocytes and protein, cytology, bacterial culture and sensitivity pattern), complete blood count (CBC), Serum amyloid-A (SAA) upon presentation and a follow up, plasma fibrinogen, plasma protein and albumin, treatments, length of hospitalisation and outcome. All medical records with the diagnosis of peritonitis were extracted from the medical records system Trofast. All records with any other diagnosis code referring to trauma such as rectal tear or ruptured uterus, recent abdominal surgery, external trauma or rupture in the gastrointestinal tract were excluded. To be included in the study, the peritoneal fluid should contain more than 20.000 cells/?L, have a peritoneal protein value of >30 g/L; or have a significantly changed peritoneal fluid sample (orange with increased turbidity or worse) in cases where no data on cells or protein were available. The horses were divided into two groups; one where the peritonitis was deemed to have an idiopathic aetiology (primary peritonitis) and the other group where the peritonitis had a possible aetiology such as intestinal parasites, impaction etc.

Laminitis is a debilitating disease causing much suffering to horses and ponies all over the world. It is manifested in the hooves as a mechanical failure of the suspensory apparatus between the hoof capsule and the distal phalanx. Due to the weight of the horse the disease may result in a dislocation of third phalanx. Six healthy standardbred trotters were used in this study on whether standardbreds tolerate forced recumbency as well as Shetland ponies. Recumbency was induced pharmacologically but maintained only by lowering the ceiling height of the box to a height of approximately 125 ? 140 % of the horse´s thoracic height.

SAMMANFATTNINGNatriuretiska peptider är en är en grupp proteiner som via natriuretiska, diuretiska och vasodilaterande egenskaper reglerar vätskehomeostasen i kroppen (Levin et al, 1998). De frisätts bland annat när hjärtmuskelcellerna utsätts för stress och kan fungera som biomarkör för att utvärdera hjärtsjukdom. Analysering av typ B natriuretic peptide (BNP) i blod kan komma att vara till hjälp för den praktiserande veterinären vid diagnostisering av hjärtsvikt och även vid uppskattning av grad av hjärtsjukdom. Det har även visat sig att BNP kan användas för att uppskatta prognosen hos hundar med kronisk klaffdegeneration (Chetboul et al, 2009; Moonarmart et al, 2010).Kronisk klaffdegeneration är den vanligaste hjärtsjukdomarna hos hund och drabbar fram för allt små till medelstora hundar från medelåldern och uppåt (Kogure, 1980). Atrioventrikulärklaffarna, vanligtvis mitralis, blir nodulärt förtjockade med inlagring av glukosaminoglykaner och fibrosvävnad vilket leder till klaffinsufficiens.

SAMMANFATTNINGNatriuretiska peptider är en är en grupp proteiner som via natriuretiska, diuretiska och vasodilaterande egenskaper reglerar vätskehomeostasen i kroppen (Levin et al, 1998). De frisätts bland annat när hjärtmuskelcellerna utsätts för stress och kan fungera som biomarkör för att utvärdera hjärtsjukdom. Analysering av typ B natriuretic peptide (BNP) i blod kan komma att vara till hjälp för den praktiserande veterinären vid diagnostisering av hjärtsvikt och även vid uppskattning av grad av hjärtsjukdom. Det har även visat sig att BNP kan användas för att uppskatta prognosen hos hundar med kronisk klaffdegeneration (Chetboul et al, 2009; Moonarmart et al, 2010).Kronisk klaffdegeneration är den vanligaste hjärtsjukdomarna hos hund och drabbar fram för allt små till medelstora hundar från medelåldern och uppåt (Kogure, 1980). Atrioventrikulärklaffarna, vanligtvis mitralis, blir nodulärt förtjockade med inlagring av glukosaminoglykaner och fibrosvävnad vilket leder till klaffinsufficiens.

Totally 84 differentially expressed mRNA clones from infective L3 larvae of the parasite Haemonchus contortus, a blood sucking nematode, were analyzed with single strand hybridization assay (SSH). Altogether 79 clones were sequenced, edited, and compared with proteins found via BLAST in GeneBank. The aim was to investigate gene expression and potential protein expression following storage at 5 °C for 32 weeks. mRNA was extracted from fresh and stored L3. The SSH derived products were cloned into E.

Apart from recognizing and neutralizing threats, antibodies also have the ability to regulate immune responses against their specific antigen. IgG administered together with erythrocytes is well known to induce >99% suppression. This has been used to prevent haemolytic disease in new-borns since the 1960's, but the mechanism behind it is still not completely understood. The effect on the primary response is well established, but its influence on induction of immunological memory is still heavily debated. In this study adoptive cell transfer of splenocytes to irradiated mice was used to survey the effect IgG has on induction of immunological memory without disturbance from the primary IgG response.

Aortic insufficiency is a very common valve problem in horses and most often affects older individuals, but nevertheless existent within younger ones. The root cause for aortic insufficiency can be varied, for example; endocarditis, ventricular septum defect or congenital valve disease but the most common are progressive valve degeneration or elite competition. Depending on the root cause, different changes can be observed on the aorta valves, but they do all have the same effect, the valves do not seal properly and blood leaks backwards. Many horses can, even with this deficiency, perform highly without any visible impacts and there is therefore no need to treat those subjects. Most often the symptoms arise at a later stage in life and they are, more often than none, put down for other reasons. In the occurrence of the clinical symptoms showing, treatment guideline is to inhibit these symptoms since the valve degeneration is presently irreversible.

This study tests two financial valuation models empirically by valuing three stocks from three industries, with the purpose of studying how well valuation models work empirically and to make a forecast. The models which will be tested are residual income valuation and discounted cash flow. Nine stocks will be picked strategically from the Swedish stock market and additional analysis will follow in the analysis chapter.Based on analysis and valuation, the commodities industry has decent valuation as the healthcare industry is undervalued thanks to the high valuation of AZN. The energy industry has low value due to the capital intensive nature of the industry. When it comes to the models and their practical implementation, DCF has been the most problematic to apply empirically whereas RIV was better but it still shows extreme values, which teaches the student the clear difference between theory and empiri..

The Internet provides the common user with a variety of both traditional and non-traditional news sources, and a vast range of possibilities to contribute to the flow of information. By their participation in the production of information ordinary citizens can sometimes function as non-traditional news sources them selves and reach a potentially unlimited audience. The interactive nature of the Internet blurs the line between producers and consumers, and challenges traditional definitions of what counts as "news" as well as who qualifies as a "journalist". The main purpose of this thesis is to examine the potential consequences of this decentralization regarding the information behaviour of newspaper journalists and their perception of their professional role. The study consists of qualitative interviews with six journalists, employed by four of the leading Swedish newspapers, and a review of earlier research in the field.

The current planning philosophy is based on a political utopic modernism founded during the first part of the 20th century. The focus is, in planning a defined area, to maximize the internal efficiency and to create a competitivesociety. During the latter part of the former century globalization changed the context, thus creating the need for a new way of approaching physical planning. This paper shows that the historical and philosophicalmetaphor of flow can be applied to meet the demands in the global city. It also shows how the edge, as where interaction takes place, is an important part of the content that has to be defined.

SAMMANFATTNINGNatriuretiska peptider är en är en grupp proteiner som via natriuretiska, diuretiska och vasodilaterande egenskaper reglerar vätskehomeostasen i kroppen (Levin et al, 1998). De frisätts bland annat när hjärtmuskelcellerna utsätts för stress och kan fungera som biomarkör för att utvärdera hjärtsjukdom. Analysering av typ B natriuretic peptide (BNP) i blod kan komma att vara till hjälp för den praktiserande veterinären vid diagnostisering av hjärtsvikt och även vid uppskattning av grad av hjärtsjukdom. Det har även visat sig att BNP kan användas för att uppskatta prognosen hos hundar med kronisk klaffdegeneration (Chetboul et al, 2009; Moonarmart et al, 2010).Kronisk klaffdegeneration är den vanligaste hjärtsjukdomarna hos hund och drabbar fram för allt små till medelstora hundar från medelåldern och uppåt (Kogure, 1980). Atrioventrikulärklaffarna, vanligtvis mitralis, blir nodulärt förtjockade med inlagring av glukosaminoglykaner och fibrosvävnad vilket leder till klaffinsufficiens.

Skin temperature is detected through signals in unmyelinated C-fibers and thin myelinated A?-fibers in the peripheral and central nervous system. Disorders in thin nerve fibres are important and not rare but difficult to diagnose by the most common neurophysiological methods. In this pilot study different methods for quantitative sensory testing, QST, were compared to give some ideas about which method could be the most efficient to use in order to point out injuries of the sensory system in clinical practice. The comparison was made between Békésy (separate warmand cold thresholds) and Marstock test (combined warm and cold thresholds).

Previous studies have shown positive results on the use of music as postoperative pain relief. Quantitative studies have examined the effect of music on rated pain and otherparameters such as anxiety, relaxation and blood-pressure. The purpose of this study was to investigate the expectations and experiences of patients and nurses onimplementing music as postoperative pain relief in an orthopedic unitQualitative design and semi-structured interviews were used to examine expectations and experiences. Five patients and five nurses in the unit were interviewed.Four themes developed during the data-analysis. These themes were ?Expectations on music as postoperative pain relief?, ?Experiences of music as postoperative pain relief?,?Effects of music as postoperative pain relief? and ?Continued implementation of musicas postoperative pain relief?.

Allt större och större andel företag väljer att presentera och förmedla varor och tjänster via e-handel. En viktig aspekt vid e-handel är att kunden känner förtroende för e-handelsapplikationen och företaget. Denna rapport redogör för vilken inverkan multimediala inslag har för förtroendet av en e-handelsapplikation, vid initialt användande. En undersökning har genomförts med hjälp av en kooperativ utvärdering av fyra e-handelsapplikationer vilka innehåller olika typer av multimediala inslag har.Resultatet av undersökningen visar att multimediala inslag inverkar positivt på förtroendet för e-handelsapplikationer. Däremot finns indikationer på att för hög grad av multimedialt inslag inverkar negativt på förtroendet för e-handelsapplikationer..