Clopidogrel is an antiplatelet substance that prevents blood coagulation in the arteries. It is an inactive pro drug that becomes activated after first-pass metabolism by the liver. The active metabolite of clopidogrel is 2-oxoclopidogrel, which is unstable therefore pharmacokinetic data is obtained by measuring the inactive metabolite clopidogrel acid in plasma. Clopidogrel is taken orally in tablet form. The aim of this project was to develop a LC-MS/MS method for quantification of clopidogrel and its metabolite in plasma. The method has been developed by optimizing the sample preparation.

The water level of Lake Mälaren has been regulated since the 1940?s. A recentinvestigation suggests that the current regulation needs to be adjusted in order toprevent a decline in water level, salt water from infiltrating from Lake Saltsjön,and risk of floodings. In addition to these preventions, the new regulation couldpotentially effect the natural environment and agriculture practices in the lowlands that surround the lake. The new regulation proposal calls for an increase invariations in Mälaren?s water level during seasons, while the annual mean waterlevel will remain the same.

The problems around and the planning of wood flow is some of the most complex issues in the forest-sector. The experience and overview of the single employees is crucial for the possibility of correct tactical and economical decision-making. The increasing demand of savings and shorter reaction-times with greater flexibility in the wood-supply-chain, makes solutions and aids for improved effectiveness in the work and processes according to wood-flow urgent. Holmen Skog is starting to develop a new forest-road-management-system. The system will facilitate the work according to construction, improvements and updating the standard of roads.

Bachelor thesis ? ControllerEconomics, Linneaus UniversityTitle:From data to information ? a case study at Södra Cell Mönsterås Authors:Sofie Gotting, Renée Lundberg and Emma Molin Tutor: Anders Jerreling Examiner: Fredrik Karlsson In Sweden, the process industries employs nearly 600 000 people and it accounts for about 60 percent of the country's net export. In many industries today, there is a growing emphasis on calculations. They are used to manage and control the activities in today?s organizations, one of these industries is the process industry.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Bakgrund: År 1991 lanserade WHO och UNICEF "Baby Friendly Hospitals Initiative" (BFHI). Motivet var den nedåtgående amningsfrekvensen världen över och de konsekvenser som det medförde till exempel socialt och ekonomiskt. Till grund fanns innocentdeklarationen som bygger på att alla BB avdelningar skall följa "tio steg till lyckad amning. Målet med detta är att främja, stödja och skydda amningen. Forskning visar att amningsfrekvensen har sjunkit de senaste åren i Sverige.Syfte: Syftet var att undersöka nyblivna mödrars upplevelse av stöd i sin förberedelse och uppstart av amning i Kronobergs län och jämföra detta med mödrar vid tre andra kvinnokliniker (Blekinge län, södra Kalmar län och norra Kalmar län).Metod: Undersökningen har en kvantitativ ansats.

This report is about the development of a prototype of a mobile application and a web application that will help diabetes patients in their own treatment and ease diabetes nurses work with their diabetes patients. The mobile application is a digital version of a diabetes diary used by the Örebro County Council primary care to ease in diabetes treatments. The report also covers tests with users which were conducted on potential users to get some sort of feedback from groups other than customer and colleagues. Tests with users showed that there was an interest in a mobile application and it was a highly appreciated project. The web application ease diabetes nurses in their work with their diabetes patients in the way that the web application can display graphs of the patient's blood glucose level. .

Inledning: Distriktssköterskor har ett stort ansvar gällande blodtrycksmätning samt uppföljning av patienter med risk för hypertoni eller som behandlas för hypertoni inom primärvården. Blodtrycksmätning är en undersökningsmetod som förutsätter att den utförs korrekt med hänsyn till felkällor och rätt förfarande för att mätvärdet ska kunna tolkas rätt. Det finns ett flertal olika riktlinjer för hur standardiserad blodtrycksmätning bör utföras. Att arbeta hälsofrämjande är grundläggande i distriktssköterskors förhållningssätt och samtal kring livsstilsåtgärder är en viktig del i samband med behandling och förbyggande av förhöjt blodtryck. Syfte: Syftet med studien är att kartlägga hur blodtrycksmätning går till vid besöket hos distriktssköterskan samt vilka aspekter som tas upp i samtalet i samband med besöket.

This thesis is conducted together with the environmental- and health department in Halmstadcommunity. The thesis is about allowance of bedding and water supply for pig farms inHalmstad community. These farms are chosen randomly from all of the pig farms inHalmstad community. It includes inspection of 27 pig farms and writing of a report. Duringthe inspections I study the amount of bedding, what kind of bedding, water supply andinjuries like lameness, shoulder-bone sore, ear-, flank- and pig tail biting.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

After I heard that two deadly accidents in farming 2003 were created by work with cattle, I got the idea of writing this degree project. So far there are not too many reports written about safety for the worker nor the animal. Therefore it will fit in with a report about safe handling of free stalled cattle. The Swedish Board of Agriculture would also like to do an information material about outside stalled cattle with this degree project as a background. The collecting of material was made by visiting farmers. The goal was to visit 15 ? 20 herds and when this is being written 19 herds have been visited.

Biogas is a renewable energy source that is produced by anaerobic digestion of organic mate-rial. In Sweden, biogas predominately comes from sewage water sludge and landfills or from organic waste of households and industries. Small scale digestion plants at farms are espe-cially expected to contribute to increased biogas production in the future. Biogas can be ob-tained directly in it?s raw form and used as fuel in a combustion chamber.

Rabbits, Oryctolagos cuniculus, rapidly increases as pets. During the right circumstances, rabbits are friendly, social and playful. A rabbit who shows an abnormal behavior should always be examined by a veterinary, though there is almost always a medical problem. This essay is a result of a literature studie with the aim to find the prophylactic measures that may give pet rabbits a more healthy life. Rabbits have got a lot of common health problems, including dental, skin and gastrointestinal problems.

Atopic dermatitis (AD) is a complex, often lifelong allergic disease affecting around 10 % of both dogs and humans. The hallmark symptom is severe pruritus, causing a lowered quality of life. Mast cells (MCs) are known to play an important part of the immunopathogenesis, promoting a faulty T helper cell type 2 (Th-2) response which follows by a production of specific immunoglobulin E (IgE) antibodies towards environmental allergens (Ag). To further investigate the role of MCs and its mediators in the progression of AD, a low-calcemic vitamin D3 analog (MC903) was used to induce AD-like symptoms locally on the ears of two different knock-out (KO) mouse strains. The first strain was Wsh-/- mice deficient in MCs.