Myxomatous mitral valve disease is a common disease in older dogs of small- to medium-size breeds. The mitral valve, and less commonly the tricuspid valve may be affected which causes them to leak blood from the ventricle to the atrium of the heart during systole. With increasing severity of mitral valve leakage the forward stroke volume ejected into the aorta decreases, which may lead to an increase in blood pressure in the pulmonary vein resulting in pulmonary edema. A decrease in cardiac output may lead to a decrease in blood pressure, but the body may respond in order to normalize the blood pressure. Franzén showed in 2007 that the systolic blood pressure was increased in dogs with severe mitral insufficiency.

Joint-related diseases including hip dysplasia (HD) and elbow arthritis (ED) can in advance cases lead to that the dog has to be put down, and these diseases are also the cause to expensive veterinary treatments of many large breeds, including Labrador Retrievers. The aim of this study was to make a follow-up study on the 271 Labradors, who previously participated in a study on the effect of nutrition and exercise on hip and elbow status in a birth cohort born year 2000. That study investigated the relationship between nutrition, exercise, and HD and ED. A follow up study on the same dogs at 5-6 years of age investigated the clinical effects of the radiological hip and elbow status at 1 years of age and if was effected by body condition score. This study took place in 2011-2012 and 187 Labrador retrievers participated.

The Bovine respiratory syncytial virus (BRSV) causes bronchiolitis and interstitial pneumonia, predominantly in calves, and is a major cause of bovine respiratory disease worldwide. In humans, BRSV is paralleled by the closely related Human respiratory syncytial virus (HRSV), an important cause of respiratory disease, most severe in infants.The clinical signs and pathology during RSV infection is caused, not only by the direct effects of viral replication, but also by the response of the host immune system. The immunopathology of RSV has long obfuscated our understanding of the disease, and development of effective treatment and vaccines will be very difficult until greater knowledge is gained.One of the components of the immune system that has come into focus in RSV research the last few years, is the Toll-like receptor 4 (TLR4). The TLR4 receptor is well known as the receptor that binds lipopolysaccaride (LPS), and initiates the host response to bacterial infection. Recently, it has been shown that the fusion protein of RSV also interacts with, and up-regulates the expression of, the TLR4 receptor.

Today's fierce competition means that companies constantly must develop their business and internal processes. Focus on processes and continuous improvement is something that characterizes Lean Production which ICA logistics are applying with their concept Leading Logistics. Standardized routines for handling damaged gods were insufficient at the ICA distribution center in Kungälv. Handling and registration of damaged gods were not performed uniformly, resulting in problems with controlling and monitoring the process.The purpose of this thesis was to analyze and make recommendations how the process of internal handling of damaged gods could be improved. Therefore a comprehensive understanding was needed of the entire material flow through the warehouse and important quality aspects such as product safety and delivery reliability.The methods used are literature reviews, interviews and observations to produce a comprehensive process mapping of the current situation at the distribution center.

Claw health has been recorded by claw trimmers at trimming in Sweden since 1996, but data was then captured at each AI association. From 2003 data was captured by central scanning and entered directly to the national cow data base at the Swedish Dairy Association (SDA). This reporting was introduced because SDA wanted to be able to use these records to improve dairy cow claw health by breeding. It is desirable with cows that have healthy claws, because poor claw health can contribute to impaired production and fertility. The claw health report begins with some information about herd, claw trimmer, date et cetera and continues with the part where the claw health is recorded. Here the ID of each cow is filled in and on the same row the conditions for dermatitis, heel horn erosion, sole haemorrhage and sole ulcer are recorded as no lesion (blank), slight lesion (/) or severe lesion (X).

Background:  Heart failure is a multidimensional phenomenon with high mortality. Heart failure is treated with angiotensin converting enzyme (ACE) - inhibitors or angiotensin receptor blockers (ARBs) that counteract neurohormonal stimuli that occur in heart failure, as well as providing vessel dilatation, which reduces symptoms and the need for hospitalization and increases survival. Despite this, only about 50% of heart failure patients survive 6 years after diagnosis with drug therapy, and as heart failure is increasing globally, due to improved care and treatment and increasing life expectancy of the population, there is a great need for new drugs such as LCZ696 that acts by dual inhibition of the renin - angiotensin - aldosterone system and neprilysin inhibition.Objective: The aim of this literature study was to evaluate the efficacy of current treatment and possible future treatments on mortality and morbidity in heart failure patients.Results: The examined articles show that treatment with ACE inhibitors in patients with symptomatic heart failure reduces the risk of total mortality by 16% over 3.5 years, reduces all-cause mortality or hospitalization due to heart failure with NNT (number needed to treat) = 10.4 over 3.5 years and increases median survival by 9.2 months over 12.1 years in patients with asymptomatic heart failure. Treatments with high-dose ACE inhibitors reduce mortality and hospitalization because of cardiovascular causes and hospitalizations from any cause by NNT = 30 over 3 years. Beta-blockers reduce sudden death and total mortality and cardiac death or non - fatal myocardial infarction with NNT = 38 and NNT = 23, respectively, over 12 months.

As a consequence of increasing wind power installations in the Nordic grid the last years, the need for regulating power has become larger. In the Nordic grid, regulating power is mainly provided by hydro power. One part of the regulating power is called frequency control, which ensures that the grid frequency is stable and close to 50 Hz.However, setting the turbine into frequency controlled operation may cause stress and wear of the components in the mechanical control system. Frequency controlling implies large and frequent servo forces and longer travelling distance of the sliding bearings in the Kaplan turbine.Based on one selected Kaplan turbine, Selsfors G1, measurements and MATLAB calculations have been performed in order to determine forces and movements of the linkage system. With these forces and movements as input, stresses and fatigue have been determined as well as sliding distances, bearing pressures and wear of bearings during a typical lifetime of 40 years.The results indicate that no severe wear exists on the bearings during 40 years of service.

The aim of this study was to analyse ninth graders self reported screen based activities, sedentary time and musculoskeletal symptoms and pain intensity. The other aim was to examine changes regarding musculoskeletal pain and inactivity between ninth graders from a cross sectional study in year 2004. To meet this aim, following questions were designed: How is the relationship between screen based activities, inactivity, musculoskeletal symptoms, pain intensity and differences between girls and boys? How have musculoskeletal symptoms and screen time changed since year 2004?Method: The method used for this study was a quantitative method. The research was carried out using a questionnaire that was answered by pupils from 11 schools from all over Sweden.

BakgrundVårdrelaterade infektioner (VRI) har funnits lika länge som patienter har vårdats. Redan på 1800-talet steg läkaren Ignaz Semmelweis fram och förespråkade för att skrubba händerna med klorid i syfte att förhindra spridning av bakterier från obduktionsbordet till förlossningsavdelningar. Trots den tidiga kunskapen om god handhygien drabbas patienter världen över av VRI. I Sverige under våren 2012 drabbades 8,9 % av alla somatiskt sjuka patienter som vårdades på något sjukhus av en VRI. Syftet med litteraturstudien har varit att beskriva åtgärder för att förebygga uppkomsten av vårdrelaterade infektioner.MetodEn allmän litteraturstudie baserad på Forsberg och Wengström (2008) har genomförts.

It is not uncommon for math difficulties and reading difficulties to occur simultaneously. Despite this, math and reading difficulties are thought to have different cognitive profiles where math difficulties are linked to number sense; an innate ability to understand, approximate and manipulate both quantities and numerical information, whereas reading difficulties are linked to phonological ability; an innate ability to understand, create representations of and manipulate phonological information. A possible link between the difficulties is that phonological abilities also could affect mathematical ability. Support for this comes from studies where comorbid math and reading difficulties are associated with more severe difficulties in arithmetic ability compared to those with isolated math difficulties. The purpose of this study is to examine whether isolated math difficulties, isolated reading difficulties and comorbid math and reading difficulties can be linked to deficits in number sense, phonological ability or both of these, and whether comorbid math and reading difficulties differ in performance in mathematical tasks compared to isolated math difficulties for children in second grade.

Audiological rehabilitation is a complex process and can involve medical, educational, psychological, social and technical proceedings. The audiologist's part in this process is essential. The purpose of the study was twofold: to describe the audiologist's working process and to explore patient records written by audiologists according to structure, content and comprehensiveness. Method. Out of rules and regulations, code of ethics and literature concerning audiological rehabilitation from the audiologist's point of view, a model for the audiologist's working process was developed.

Aim: The aim of this study was to investigate how women who have incurred ACL injury for more than 10 years ago, feel that the injury affects them today.Method: A qualitative semi-structured interview survey with five women who 10- 28 years ago incurred the anterior cruciate ligament injuries when playing handball or soccer has been performed. The study has been inspired by a phenomenological concept of science, mainly by life-world concept. Data were analyzed using qualitative content analysis.Main result: Some informants have experienced severe loss of physical ability in both daily living situations and in training, while others did not appreciably felt impacted in daily living and experienced great opportunities for physical activity. Limitations which emerged were restrictions in movement, joint stiffness, pain, swelling, and crepitations that led to the loss of physical ability. One respondent had been diagnosed with advanced osteoarthritis.

Severe acute respiratory syndrome (SARS) är den epidemi som 2003 spred sig från Guangdong provinsen i Kina till 26 länder runt om i världen. Sjukdomen som orksakades av SARS-coronavirus (SARS-CoV), drabbade under utbrottet 8098 personer och tog 774 liv. SARS är ett utmärkt exempel på hur en dödlig sjukdom kan komma från ?ingenstans? för att snabbt, spridas med hjälp av vårt globaliserade samhälle. Viruset utsöndras med luftvägssekret, feces och urin och kan under fuktiga och gynnsamma omständigheter vara infektionsdugligt i upp till fyra dygn. I regel krävs direktkontakt eller nära kontakt mellan smittbärare och frisk individ för att sprida viruset vidare.

The subject for this paper is the Class Action against Skandia Association, a civil organization formed in 2003 with the aim of claiming compensation for some 1.2 million life insurance customers. The background to its formation was one of the largest financial scandals in Sweden in recent times, involving a number of questionable affairs within the insurance corporation Skandia and its subsidiaries, most notably the life insurance company Skandia Liv. The interests of both the stake- and stockholders of the company seem, in certain ways, to have been grossly misrepresented. The scandal, as well as the reaction it spawned, pose a number of questions. In this study, we focus on two: a possible, and in many ways apparent crisis in the representation of interests in Swedish society, and the role of civil society in upholding the balance between these interests.We argue that what is often held to be the ?greed? or ?immorality? of individuals in scandals such as Skandia is, to a great extent, a mere reflection of the ?rational? underpinnings of modern-day capitalism.We find that trust has been a key mechanism of control in the relationships between consumers and agents in pension and life insurance markets, and that ?the Swedish model? that distinguished post-WWII Swedish society was a model heavily based on trust towards existing models of bureaucratic governance.

The technological development and increasing popularity for integrated multichannel solutions constitutes both severe opportunities and challenges for todays' and tomorrows' retailers. On the account of consumers leaving traces when using digital channels and the technological development enabling retailers to use this information to create relevant offers, goal-congruity is relevant to apply in the multichannel shopping context. Based upon previous research on goal congruity and channel integration, our main purpose in this study is to increase the understanding for how congruity in an offer increases the intention to redeem the offer. Several studies focus on and contrast the product characteristics hedonic and utilitarian. However, it has been stated that it is crucial that research also examines the difference in target audience, buying situation and as examined in this study: buying decision process.