Introduction: Sex and education level has demonstrated effects on health status.Osteoarthritis is a widespread disease that causes reduced health-related quality of life and isthe most common reason for total hip replacement. Osteoarthritis was ranked as the 11thhighest contributor to global disability as reported in the Global Burden of Disease 2010.Aim: The aim of this study was to explore how sex and education level together affectedhealth-related quality of life after total hip replacement. The aim was also to examine whatdimensions of EQ-5D that changed.Methods: The study is a prospective observational study with a quantitative approach. Dataconsisted of education level, obtained from Statistics Sweden (SCB) and health-relatedquality of life before and one year after total hip replacement from the Swedish HipArthroplasty Register (SHAR). Health-related quality of life was measured with astandardised instrument, the EQ-5D, and the study population consisted of 39,141 patients.Results: Womens? EQ-5D-value, before and one year after surgery, were lower in alleducational categories compared with men.

Can degree of degenerative brain disease be predicted with the help of measurements of cognitive deterioration?Alzheimer?s disease progresses through nerve cell break down in the brain and the simultaneous deterioration of the individual?s cognitive function. This disease is common among elderly persons. This thesis examines if the level of deterioration of cognitive function is associated with different biochemical and clinical markers for degenerative brain diseases. In addition, this thesis examines if the level of decline in cognitive functions vary between groups with different levels of degenerative brain disease.

Background:Alzheimer's disease is a disease that primarily affects the elderly but also younger people. Alzheimer's disease is a type of dementia which means that you get changes in the cerebral cortex and cells gradually die. The disease causes memory loss and things that were obvious before will be difficult for the sufferer. Alzheimer's disease also affects next of kin to a large degree; they will have to take a great responsibility. The next of kin are entitled to support from healthcare.Aim:The aim was to highlight next of kin' experiences of healthcare to their family members with Alzheimer's disease.Method: The study was based on narratives, which in this case means analysis of autobiographies.

Peste des Petits Ruminants (PPR) is a disease of major socioeconomic impact. It is an acute and highly contagious viral disease of small ruminants caused by the agent Peste des Petits Ruminants Virus (PPRV), a Morbillivirus closely related to Rinderpest virus (RPV) which was declared eradicated from the world in 2011. PPR has a high morbidity and mortality rate and is characterised by high fever, nasal and ocular discharge, pneumonia, necrosis and ulceration of the mucous membranes and inflammation of the gastrointestinal tract causing severe diarrhoea. The role of wildlife in the epidemiology of the disease is still unclear. The disease is currently affecting sheep and goat in 70 countries worldwide and this year (2014) FAO has announced a program to eradicate the virus by 2030. In Tanzania, the disease was first reported in 2008 and has since then spread to different parts of the country.

Background: HIV/AIDS has existed officially for more than 35 years and is now seen as a global epidemic. The disease has claimed many victims and there is no indication showing decrease of the mortality rate. The disease is currently incurable, but antiretroviral drugs have good effect at slowing down the process. The persons who live with the disease are exposed to stigma and, sometimes, negative attitudes. The negative attitudes could affect the person?s willingness carry through the test.

Background: Multiple Sclerosis (MS) is a chronic disease that mainly strikes young people in working age, twice as many women than men falls ill. Approximately 85 % suffers from MS-related fatigue that divides itself from common fatigue in that way that it is persistent and does not disappear in spite of sleep. This fatigue is experienced of many as one of the most difficult symptoms, which has considerable impact on the everyday life. Aim: The aim with the study was to elucidate how MS-related fatigue was experienced by persons with MS. Method: The study has been implemented as a literature study through systematic review of scientific articles.

Background:Alzheimer's disease is a disease that primarily affects the elderly but also younger people. Alzheimer's disease is a type of dementia which means that you get changes in the cerebral cortex and cells gradually die. The disease causes memory loss and things that were obvious before will be difficult for the sufferer. Alzheimer's disease also affects next of kin to a large degree; they will have to take a great responsibility. The next of kin are entitled to support from healthcare.Aim:The aim was to highlight next of kin' experiences of healthcare to their family members with Alzheimer's disease.Method: The study was based on narratives, which in this case means analysis of autobiographies.

In this essay dog as a compatible model were put against human. The major histocompatibility complex (MHC) genes were compared between dogs, human, cat and mouse. To evaluate dog as a model and study similarities and differences was the aim with this review. Dog as a model contributes to understand mechanisms behind autoimmune diseases and showed clearly histological similarities between human and dogs concerning the skin disease mucous membrane pemphigoid (MMP)/cicatricial pemphgioid (CP). Further genetic evidence motivated the choice of using dog as a comprehensive model when the MHC-complex correlated with hypothyroiditis in Doberman dog as it does in human. Physiological similarities with low levels of thyroid hormones (T3 and T4) together with high level of thyroid releasing hormone (TSH) were found in the same way as in human.

Borna disease virus (BDV) is a virus with capability to cause neurological disease in several species of mammals and of ostriches. Also humans are suspected to be susceptible to the virus, as the viral RNA and antibodies against BDV have been found in some humans with psychiatric diseases, like schizophrenia and depression. In Sweden there is a disease called staggering disease in cats, associated to BDV-infection. This disease often has a fatal progress. Definite diagnosis is reached by histo-pathological and immunohistochemical examination of the central nervous system.

Ear disease and hearing loss in preschool children can be difficult to discover and diagnose. This paper investigates ear disease in 20 children controls from 1 to 5 years of age. The aim of the study was to map prevalence and incidence for ear disease, and prevalence of hearing loss in a group of children.Twenty children wide aged 1, 1½, 3 and 5 were included and investigated according to a set protocol with psychoacoustic tests, tympanometry, ear microscopy and a parental questionnaire. The majority of the children could be evaluated by age adequate psychoacoustic tests and otoscopy. Tympanometry was the investigation method that was most difficult to perform.

Background: Alzheimer?s disease belongs to the largest group of dementia and stands for the half of those 37 millions persons whom are affected of dementia in the entire world. Alzheimer?s disease affects the patients with changes on their behaviour. It is important as a nurse to prevent that the symptoms increase.

Virulent strains of Staphylococcus hyicus produce exfoliative toxins and cause a potentially fatal skin disease in piglets known as exudative epidermitis. Vaccines and antimicrobials are used to control the disease. Antimicrobial resistance and the prevalence of several different toxin genes and toxigenic strains make it problematic. The aim of this literature study was to identify potential differences between countries and between healthy and diseased pigs regarding antimicrobial resistance and toxin-producing strains. Great differences could influence vaccine production, treatment strategies and surveillance programs.

Background: Heart failure is a complex condition which means that the hearts capacity topump blood is reduced. The aim of this study was to investigate how patients with heartfailure considered their knowledge and the information they received about their disease andself-care.Method: Patients suffering from heart failure, hospitalized at section 30 E (n=13), andpatients visiting the nurse led heart failure clinic (n=4) at Akademiska sjukhuset in Uppsala,were requested to participate in the study. The patients answered questions about knowledgeand information concerning self-care and their disease. Data were analyzed using SPSS 15.0.Results: The patients valued their knowledge about the disease as lower than their knowledgeabout self-care. The study showed that all the patients found the information they hadreceived about their self-care better than the information they had received about theirdisease.

The purpose of this essay is to describe and analyze experiences of how the daily rounds and a persons role is changing when you go from being a family member to being a family member as well as being a kinship carer.Essential questions at issue was:- Which feelings are associated to the roll as kinship carer?- What are the motivations for the relative/family member to become a kinship carer?- What is the change of the role like before and after the disease.Six persons have been interviewed on the subject and symbolic interactionism and role theory has been our theoretical perspective. The essay has been related to the ideas of Meads on social interaction and to Goffmans theatre theorem.The result of the essay showed that feelings and motivations as regards to the daily rounds and the role of the kinship carer were individual, where similarities and differences occurred. When ones partner, parent or child got a disease/functional disability it generated in some changes regarding their daily rounds and it led to altering of roles. To assume a role was a natural result and often happened when a relative/family member got a disease or an injury..

Celiac disease (CD) is an autoimmune disease, induced by an immune mediated reaction in the small intestine after ingestion of gluten and related prolamines. There is a strong genetic linkage and most important are the genes that encodes for HLA-DQ2 and HLA-DQ8. The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has developed new guidelines for investigation of CD in children and adolescents, which include genotyping for HLA-DQ2 and HLA-DQ8. Therefore, the clinical microbiological laboratory in Västmanland wants to introduce a method for analysis of these genes. Microarray is a newly developed method for determination of the alleles HLA-DQA1 and HLA-DQB1 that encodes for the ?- and ?-subunits of the HLA-molecules.