Kolorektal cancer (CRC) är en av de vanligaste cancersjukdomarna i världen med cirka 1 miljon nya detekterade fall per år. Special AT-rich sequence-binding protein1 (SATB1) är ett celltyp-specifikt kärnmatrix-associerat DNA-bindande protein, vilket utgörs av AT-rika DNA sekvenser. Det har tidigare demonstrerats att en annan medlem i SATB-familjen, SATB2, uttrycks på ett vävnadsspecifikt sätt i normal mukosa i nedre mag-tarmkanalen och i CRC. ?-catenin är en intracellulär mediator i Wnt/?-catenin signaleringsvägen, som spelar en viktig roll i kolorektal carcinogenes.

Föreliggande uppsats utgår från ett potentiellt problem för Försvarsmakten att i det nyligen införda tvåbefälssystemet omhänderta den högskolemässigt utbildade officeren som sannolikt generellt innehar en högre utbildningsnivå och mer uttalad karriärambition än de äldre yrkesofficerarna från det tidigare enbefälssystemet NBO.Uppsatsens syfte är att tydliggöra vilka förutsättningar på arbetsplatsen som gäller för tvåbefälsystemets högskolemässigt utbildade officerare vid officersprogrammet ur ett anställningsbarhetsperspektiv. Anställningsbarhetsbegreppet kommer att utgöra det redskap som jag applicerar på det avgränsade empiriska materialet för att se vilka förutsättningar, som gäller på arbetsplatsen i jämförelse med kraven i examensbeskrivningen för de högskolemässigt utbildade officerarna då de tagit examen sommaren 2010. Är de anställningsbara? Genom en dokumentgranskning tolkas och jämförs de dokument som ligger till grund för officersutbildningen och de strategiska styrdokument som definierar Försvarsmaktens verksamhet.Resultatet visar utifrån ett anställningsbarhetsperspektiv att Försvarsmaktens dokument och officersprogrammets utbildningsplan samt examensbeskrivning i stort sett stämmer väl överens vilket borgar för en hög anställningsbarhet hos officeren..

The relationship between free trade and the environment is often considered conflicting and the debates surrounding it are infected. My thesis deal with this conflict and how environmental concerns are integrated in three regional free trade agreements, North American Free Trade Agreement, The common market of the southern cone (MERCOSUR) and Southern African Development Community (SADC). I point out how the organizations differ from each other in this respect and I present a possible explanation to why they differ. The explanation is founded on the theory of the environmental Kuznets curve and that environmental concerns will depend on which level of development the member states in the organizations have. To judge and rank the organizations I have composed a model based on a pre-existing description of the trade and environment conflict.

Objectives: The purpose of the study was to examine if a pre- and post-operative difference could be seen in self-reported pain disability and self-efficacy among patients undergoing surgery as treatment for spinal disc herniation in order to improve process of rehabilitation.Method: A quantitative and descriptive design was used. 10 patients awaiting surgical treatment for spinal disc herniation were included at Akademiska sjukhuset (The Academic Hospital) in Uppsala. Participation was voluntary and the selection was made by convenience. Data was collected using The Pain Disability Index and Self-Efficacy Scale by which the patient would estimate how hindered they felt because of their pain in everyday activities and their self-efficacy to perform everyday activities. This was done the day before surgery and two weeks after surgery.

The purpose of this study was to describe perceived psychosocial work environment and musculoskeletal complaints among baggage handlers, and to evaluate whether there is any linear relationship between them. The study is a questionnaire based cross-sectional study, and part of an ongoing larger project. Therefore, the number of forms has been limited to those that were collected in the project by 2010-11-25 (N=117). The questions analyzed in the study come from the Copenhagen Psychosocial Questionnaire and ?Nordiska Ministerrådets formulär om besvär i rörelseorganen?, respectively.

Future emission legislation puts great emphasis on increasing the efficiency of the engine, thereby reducing fuel consumption. The tribological contact between cylinder liner and piston ring is where an great amount of energy is lost due to friction, and by reducing these losses an reduction in fuel consumption can be achieved.The aim of this thesis was to evaluate the tested piston ring coatings against a plasma sprayed cylinder liner and rank these combinations of materials for friction and wear resistance. The coatings that were tested was Cr + Al2O3, (Al,Cr)N, two types of CrN and WC / C.The experimental tests were performed with a so-called pin-plate, where used oil with addition of an acidic mixture of sulfuric and nitric acid to mimic the acidic condensate formed when exhausts recirculate, were added with a continuous flow. The results were then analyzed by weighing, studies by optical microscopy and scanning electron microscopy (SEM) and profile measurements.The results from each material combination were that the plasma coated cylinder liner wears too aggressively in order to yield a ranking of the piston ring coatings based on the parameters of friction and wear resistance. It is therefore proposed that an alternative coating on the cylinder liner should be developed, lacking the large abrasive wear on piston rings and that can withstand the corrosive environment resulting in engines equipped with EGR.

Att förstå sambandet mellan miljövariabler och fiskarters förekomst eller abundans är en väsentlig del i att bedriva ekosystembaserat bevarandearbete och ekologiskt hållbart fiske. Tånglaken, Zoarces viviparus, var klassad som nära hotad på rödlis-tan 2010 och på HELCOM Red List of the Baltic Sea 2013. Tånglaken är utbredd över hela Östersjön och används som en bioindikator för föroreningar i havet Att förstå vad som styr tånglakens utbredning är alltså viktigt både ut bevarande syn-punkt och ur miljöövervakningssynpunkt Meningarna går isär angående dennes ha-bitatpreferenser. Med hjälp av data i form av uppmätt djup och videosekvenser från provfisken inom projektet BONUS INSPIRE och data i form av rasterkartor för andra miljövariabler har generalized additive modelling gjorts för tånglakens före-komst i Östersjön. Tre slutgiltiga modeller valdes ut baserat på förklaringsgrad.

Future emission legislation puts great emphasis on increasing the efficiency of the engine, thereby reducing fuel consumption. The tribological contact between cylinder liner and piston ring is where an great amount of energy is lost due to friction, and by reducing these losses an reduction in fuel consumption can be achieved.The aim of this thesis was to evaluate the tested piston ring coatings against a plasma sprayed cylinder liner and rank these combinations of materials for friction and wear resistance. The coatings that were tested was Cr + Al2O3, (Al,Cr)N, two types of CrN and WC / C.The experimental tests were performed with a so-called pin-plate, where used oil with addition of an acidic mixture of sulfuric and nitric acid to mimic the acidic condensate formed when exhausts recirculate, were added with a continuous flow. The results were then analyzed by weighing, studies by optical microscopy and scanning electron microscopy (SEM) and profile measurements.The results from each material combination were that the plasma coated cylinder liner wears too aggressively in order to yield a ranking of the piston ring coatings based on the parameters of friction and wear resistance. It is therefore proposed that an alternative coating on the cylinder liner should be developed, lacking the large abrasive wear on piston rings and that can withstand the corrosive environment resulting in engines equipped with EGR.

Authors: Lars Johansson & Johan PetterssonTitle: ?There is way to much sports in the athletics? ? A study of Swedish sportsFootball has gone from being a hobby and a popular pastime into a billion-dollar industry, and clubs around Europe are therefore operated more and more like regular companies. Sweden's position in the UEFA rankings is a modest 23 rd place, behind nations such as Austria, Switzerland and Belarus. The economic climate in Sweden is often highlighted as a strong factor. When we started our study we agreed that this could be a major contributing factor to this relatively modest rank, but believed that there were also other factors that played a big role.

The governance and control of healthcare organizations has traditionally been run byprofessions inside the organization (Fölster et al., 2003). During the last decades Swedishhealthcare has undergone an institutional transformation where the governance has changedfrom professional governance to a more market like one (Sahlin-Andersson, 2006). Governingof healthcare can however be problematic as professional work is characterized by a highlevel of autonomy and tacit knowledge (cf. Tsoukas, 1997, Freidson, 2001). An expression ofthe new kind of governance is the annually published report ?Öppna jämförelser av hälso- ochsjukvårdens kvalitet och effektivitet?.

There has been an increasing interest for ranking of Swedish health care and a lot of emphasis has been placed on the creation of indicators in order to rank hospital units. However, essays on to what extent the choice of statistical method affects the final result of the ranking of health care units have not been given the same attention. For this particular reason, the main objective of this essay has been to investigate whether the choice of statistical model has a significant impact or not on the final result, by using five different, more or less common, statistical approaches: bar charts (with and without confidence intervals), control charts, logistic regression, multi-level analysis using shrunken residuals. The analyzed material in the essay comprises 24119 patients that all have been prescribed some form of the lipid-reducing medicine statin. According to directives given by Region Skåne, doctors are encouraged to prescribe a particular type of statin medicine, namely Simvastatin, which has been proved to be equally effective, but significantly cheaper than other statin medicines.

Det är idag vanligt inom verksamheter som skola och omsorg att använda rankningar för att utvärdera kvalitet och skapa beslutsunderlag, något som är behäftat med stor osäkerhet. Trots det redovisas ofta dessa utan speciellt tagen hänsyn till den närvarande slumpvariationen. Mot bakgrund av det har vi varit speciellt intresserade av sådana data och har för uppsatsen haft tillgång till skoldata samt tre olika sjukvårdsdata. För att identifiera om och när en rankning kan vara meningsfull har vi för samtliga data jämfört länsnivå med lägre nivåer.Uppsatsen behandlar den slumpmässiga variation som framträder i samband med upprättandet av rankningslistor. Då små enheter är mer mottagliga för naturlig variation, förväntas denna har särskild betydelse för placeringen och inte sällan återfinns dessa i toppen eller botten av tabellen.

This study focuses on small scale hydropower in Sweden. This means plants with a capacity of up to 10 MW. The study has a special focus on plants with a capacity up to 2 MW. The study has three aims. It strives to describe the small-scale hydroelectric industry in Sweden.

During the past twenty years, the Swedish school systems have slowly changed to becomemore and more performance-driven. Private schools have been growing in general and, likeindependent schools and schools managed by municipalities, they profile themselves. Schoolsare becoming more performance and result-oriented, which has changed the roles of teachersin a dramatic way and is in general, still changing.By profiling students based on theirindividual performance, schools are able to help students identify themselves and their owngoals. The process of profiling is a slow one in which some teachers adapt more quickly thanothers, and one that is critical for other teachers to learn in order to keep up with the demandsof society.Schools, like ordinary businesses, are in constant competition with each other to keep up withthe newest and greatest models of teaching and to rank among the best in high achievements.Perhaps the downside of this modern school structure is that it is often difficult to have aschool where both school management and teachers see eye to eye. School management must heavily focus on the school?s results as a whole.

This study investigates certified and non-certified teachers in Sweden and how they themselves view the status of their profession. Teacher certifications were introduced to Sweden in 2011, under the assumption that it would raise the status of qualified teachers. Recent results from international studies showed that Swedish students have fallen in rank compared to other countries around the world, and one of the proposed solutions proposed to this was to raise the status of teachers, as well as their pay. A higher status would then solve other issues, such as the low number of applications to university courses related to teaching. This study asked high school teachers, through an online questionnaire, what their views were on the status change the reform was supposed to create.