Tumour development occurs to a large extent because of dysregulation of the cell cycle. Of particular importance are defects occurring in the G1 phase. The reason why G1 is critical is because of the influence of several signals (external signals as well as cyclins and cdks) on this stage. The G1 phase can be divided into two parts, G1pm and G1ps. Each part has its ?own? restriction point which needs to be passed in order to progress to S phase.

 AbstractSystem methodology is in the very heart of system development, it is a crucial part of how you define your work, how you choose to approach the actual problem at hand and how to solve it. Researchers in the system development field has shown that not all methods in theory are in compliance with how it is practiced by the companies who use them. In our thesis we have studied a larger international IT- company and one of their local offices in Sweden, who some years back changed their system development method from a more traditional to an agile one. Our aim of this study has been to establish whether both of these methods has differed between theory and in actual use, and if so, why this has occurred and what the underlying rationality might have been to promote this change. Our questions that we sought to answer were; 1.

This thesis is about new technology in academic libraries in the form of Patron Driven Acquisition. As libraries take part in the digital era, a new model of patron driven acquisition has emerged. This model gives users more influence over the libraries electronic book collection. The collection development model changes libraries traditional role in the collection development process, from collecting for the future to the present.The purpose of this thesis is to gain knowledge of what acquisition librarians think about the effects of PDA on the collection, the acquisitions role and the cost structure. The theoretical framework relies on Christensen?s theory about disruptive technology and was used to interpret outcomes of new technology in libraries and its staff.Five librarians from four different Swedish university libraries were interviewed using a qualitative semi-structured method to carry out the investigative part of this thesis.

In which ways have composing processes in music appeared over the past 300 years? How may composing processes work today? What does new technology do to this processes?The key purpose of this study is to investigate various composing processes. A further purpose is also to gain an awareness of how we use modern technology by computers and their notation programmes.The research design of this thesis includes a display of literature related to composing processes. along with an analysis of the writer?s own experiences in the area.

The intention with the research was to investigate the role of civil society in the Kenyan democratization process. The research intends thus to analyze (1) the role of civil society in Kenya's transition to democracy (1990- 2002), and (2) the role of civil society in the further democratization process (2002- 2013).The results of the research demonstrates that the role of civil society played a crucial role in Kenya?s transition to democracy given that civil society provided with a multiparty- system in 1991. In addition, civil society endowed with education for citizens in order to attain constitutional reforms. As a result, Kenya accomplished a transition to democracy in 2002.

Construction projects are organized in different shapes and disturbances in the information flow in these processes can lead to problems, such as delays and/or a lower quality. Therefore, a well-functioning interaction between actors and a well thought out-communication at an early stage is of crucial importance. The main question is "How does the communication of decision and information flow in the building process and what barriers and opportunities can be observed?". This diploma work has been written with guidance from Bjerking AB and to answer this question, a collection of empirical data conducted via semi-structured interviews.

To effectively manage a forest resource for both economic and other values good planning is required. The problem is complex since you want to know which forest to cut and when. Often a hierarchical planning structure is applied, including strategic (long-term), tactical, (medium-term) and operational level. Today SCA Forest is one of few forestry companies in the northern Sweden with an integrated forest wood supply and industry. The goals of the company are to supply their own industries with wood and to manage the resources of the forest through a long-term perspective with satisfactory profitability.

The information society creates new demands on the knowledge making individual; besides being literate one has to be information literate. And in the educational society there is an ongoing change from teaching to learning, the focal point being the active student and life long learning. The aim of this dissertation is to within a context of learning and teaching elucidate the relation between user education and subject education by examining what significance the academic libraries user education has for the development of information literacy within students. Some epistemological theories connected with learning is presented as well as aspects of the information search process and of information literacy. Universities and their libraries view of information literacy and the goal of their user education is being focused on in an empirical study.

PDF-files are to become a native file format in all prepress supplier workflows during 2006. This will give an opportunity to automate and develop a more stream lined prepress workflow. It is desirable to secure digital files by preflight the files early in the process. The objective with this project is therefore to find software that can automate parts of the preflight process and also to build up a well-functioning preflight workflow for preflighting both PDF-files and native files.Meetings have been held with preflight suppliers to find a solution for how to automate parts of the preflight in the prepress workflow. Seven preflight software companies demonstrated the possibilities with their products and four of these were chosen for continuing working with.

Background: There are many people waiting for a kidney transplant. To get a kidney from a living donor has many advantages. The gift is about giving and receiving. The decision is characterized by life-philosophy of the donor.Aim: To highlight the experiences of the kidney donation process.Methods: A systematic literature review in which 11 articles were included, seven qualitative and four quantitative. The articles are quality and ethically reviewed, the results are analyzed according Granskär & Höglund and Polit & Beck.Results: The results were gathered under two themes: the decision-process shows the path from idea to decision and implementation-process treats the donation and confirmation of the gift.

Durban, South Africa?s third-largest city is a socially segregated post apartheid society, struggling with high unemployment and AIDS. The city becomes even more complex with a changing climate, creating an influx of people to the city, putting scarce resources under further stress. Warwick Junction, an important transport hub in the centre of Durban, holds a large site of informal trading alongside the formal markets. This informal sector generates large financial flows and provides for a rapidly growing population. The aim of this thesis is to develop an approach that is realistic and relevant to planning and design of an urban context in South Africa.

This thesis consists of three parts: one normative, one empirical and one constructive, with the intention to explore the enforcement of accountability in megaprojects.The thesis aims to evaluate the level of accountability in the policy process of the European Spallation Source, ESS between 1990 and 2008. In order to make a comparison possible, a norm is created concerning how a policy process should be designed, with primary focus on openness and participation, to make enforcement of accountability possible. The policy process of the ESS is compared with this norm with the purpose of discovering whether the process contains elements that assure enforcement of accountability. After the comparison is done, it is possible to formulate constructive proposals about how the enforcement of accountability can be improved.The thesis also explores how networks, consisting of actors with particular resources, surrounding the ESS-project affects the form of the policy process, e.g. in shaping the social construction of the aim and purpose of the project.

Thesis completed by Johan Arvidsson, Alex Rasooli and Pontus Winroth, students at master program Product development and Design at the School of Engineering in Jönköping Sweden. The project comprises 30 ECTS credits and was carried out during the semester in the autumn of 2007.It was carried out in cooperation with Eksjöverken AB, subcontractor within the truck industry with special knowledge within the area of complicated machinery construction work. Job initiators at Eksjöverken were Mats Svanberg and Kjell Nygard. Dag Holmgren was acting as a tutor from the university. The task was to develop tools for trucks, primary toolboxes but in case of time also under run protection.

The study sheds light on pupils individual plans of development and portfolios from the perspective of children. It has an ethnographic standpoint. It was carried out on children and pupils in pre-school, pre-school class and third grade. By further investigating how children and pupils use their individual development plans and portfolios, in which settings and to whom they communicate them, this study is able to grasp the discourse that is created around the instrument itself. This study is also interested in and aims to find the theoretical frame, in essence, which envelops both the construction of childhood and children?s own activities within the limitations and opportunities that this structure offers.

Our modern society is in many ways built with and dependent on fossil fuels, which are used for energy production as well as for transporting humans and goods. Without the oil, many of the things we take for granted would not be possible. During the last century, the use of oil has increased steadily and will probably keep increasing as the world population and the economic well-being for many people increase. Since the oil is a finite resource, we will have to find other fuels that can replace it if we want to keep the same rate of development in the future as the availability of petrol fuels will decrease with rising prices as a result. Furthermore, fossil fuels have the disadvantage that they produce harmful emissions when combusted and thus affect the climate and air quality locally and globally.