Introduction The genetic skin disease epidermolytic ichtyosis is caused by mutations in either keratin gene 1 or 10 and leads to blisters and hyperkeratosis of the epidermis. At cellular level the disease is seen as aggregates in the keratin filaments. Since medicines are hard to investigate and produce mainly due to lack of reproducible model systems, there is no good treatment available for this disease today. In this article we describe how an in vitro model consisting of cells from a stable cell line transfected with expression plasmids to mimic patient cells, may be a possible alternative for screening compounds for therapies. The first step was to generate an expression plasmid required to complete the in vitro model.

Fastigheter kan hållas av olika orsaker, vissa ärver och förvaltar en fastighet innannästa generation tar vid medan andra investerar i rent finansiellt syfte eller kulturelltsyfte. Likaså skiljer sig anledningen till varför man värderar egendomen, det kan varaför att bjuda ut fastigheten på marknaden, för att lägga ett bud på densamma vidnyförvärv eller av rent bokföringsmässiga skäl. Fastighetsmarknaden är komplex ochriskbilden är ofta alltför mångfasetterad för tillgängliga finansiella modeller, vilketmedför att magkänslan allt som oftast är utgör en stor del vid investeringsbeslut.I denna studie undersöktes olika investerares syn på risk. Möter allainvesterare samma riskbild eller skiljer den sig beroende på investerarens preferensför endera fastighetsslaget? Upplever aktörer i bolag med fastigheter somkärnverksamhet en annan riskbild än de vilka håller fastigheter i rentdiversifieringssyfte?En enkät skickades ut till 110 personer verksamma som VD, Finanschef ellerRiskchef, inom fastighetsbranschen.

Bakgrund: Alumninätverk är ett nätverk för tidigare anställda på ett företag eller för examinerade studenter från högskola eller universitet. Alumninätverk är ovanligt i Sverige, men i USA jobbar företagen aktivt med detta. I avslutningsskedet av en anställning kommer alumni in som en del i Employer Branding processen då ett företag vill behålla kontakten med sina före detta medarbetare.Syfte: Syftet med föreliggande studie är att få fördjupad kunskap om de för- och nackdelar som företag upplever med att inrätta alumninätverk och vilken effekt det får när ett företag inrättar ett alumninätverk.Metod: För att uppnå syftet med denna uppsats har jag genomfört en kvalitativ undersökning där jag intervjuat ett konsultföretag inom området alumninätverk för att erhålla ett expertutlåtande och fyra företag som idag driver alumninätverk för sina tidigare anställda.Slutsats: Alla företag jag har intervjuat är överens om att fördelarna med ett alumninätverk är många. Bumerangrekryteringsmöjligheten, ambassadörskapet, affärsnätverket och möjligheten att utveckla en kundkontakt i framtiden är fördelarna som främst tas upp. Min slutsats är att fler företag bör börja arbeta med alumninätverk för jag tror att generation Y kräver en strategisk Employer Brandprocess där alumni är en viktig del.

Denna rapport är en litteratur- och källstudie med syfte att utforska den svenska förnybara elens utveckling. Förnybar energi är idag viktigt i samhället då den genererar den el som vi är i behov av, utan att påverka miljön i lika stor omfattning som tidigare energislag. Målet var att efter genomfört arbete, ha svar på hur Sveriges elmix ser ut och eventuellt kunna svara på hur den kan se ut till nästa generation. Vilka tekniska lösningar som används idag för respektive kraftslag är något som återges i rapporten.Alla kraftslag påverkar miljön på något vis. Rapporten beskriver dessa miljöpåverkan med hjälp av livscykelanalyser som pekar på var i produktions- och driftprocessen som den största påverkan sker.

This thesis aims to examine the viability of various techniques for increased electricity generation in CHP plants and the effect of electricity price fluctuations on the profitability.The techniques examined are fuel dryer, pellet production, methane production, combined methane- and pellet production, seasonal heating storages in caverns and pit heat storages and condensing tail. Using Excel and Matlab, the prerequisites for investment costs, revenues and expenses were calculated.What affects the price of electricity is a combination of economic and technological development, energy prices, economic structure, population changes and weather. Different scenarios for the electricity price were therefore examined. In the base case, the electricity price was given by the Nord Pool electricity price statistics of area three in 2011. Thereafter, WiMo was used to design the electricity scenarios for 2030, which was then applied to the data to obtain the viability of various scenarios. The techniques examined were found to give greater profits to the CHP plant by increasing and optimizing the production of electricity.

This Master?s thesis is an analysis of metaphors in relation to actors, and of discourses used in the copyright-debate in two major Swedish daily newspapers and one American: Göteborgs-Posten, Svenska Dagbladet and New York Times during the years 2001-2006. We aim to answer the following questions: Which metaphors were being used in the copyright-debate to create the archetypal villain, hero, winner and loser in editorials, debate and letters to the editor in the three newspapers? Which discourses did those metaphors relate or conform to? Which similarities or differences could be found when comparing the two countries? newspapers regarding representations and constructions of villains, heroes, winners and losers in the copyright-debate? Firstly we distinguished who the actors in the debate were, following parts of Theo van Leeuwen?s actors? analysis. Secondly we distinguished which metaphors were being used to describe the actors as either villains, heroes, winners or losers.

AbstractSpotify is currently the largest and fastest growing online music service. They started in 2006 and has since established itself in several European countries. Their financial revenue comes from advertising spots on the client and registered paid subscribers. Together with Spotify, we have come to a certain focus area where Spotify themselves feel that there is potential for improvement. This area of focus concerns the conversion from using Spotify's free "Open" to the payment options Unlimited and Premium.Objective: We will use an innovation process to achieve an innovation grant that will create more attraction to the payment services.

It has been roughly 86 years since Gunnar Myrdal?s book ?The Political Element in the Development of Economic Theory? was published, in which he declared economic thought and theory as being established by hidden ideological premises. As well as accusing modern economic theory of being the subject of a pseudo-scientific construct. As such, this study seeks to test Myrdal?s critical view on Swedish economic education in upper secondary school.

The purpose of this study has been to investigate the prospects for identifying and prosecuting individuals suspected of war crimes, within the process of exclusion from refugee status under article 1F(a) of the 1951 Refugee Convention, and using subsequent mechanisms for extradition or prosecution in international criminal law. A number of principles within human rights law and public international law have been advocated by the UNCHR and several human rights NGOs as necessary for a thorough application of the exclusion clauses; one that takes individual responsibility into account and upholds the aims and purposes of the exclusion clauses. There is a discussion as to whether specialised or accelerated exclusion procedures are justified for reasons of security and efficiency, or if they put the rights of the individual at risk and limit the opportunities for gathering information to support investigation and prosecution of the crime in question. Apart from the instruments of asylum law and procedure that have emerged within the EU harmonisation process, there are no general, binding rules on the procedural aspects of the exclusion clauses. One principle that regulates the consequences for the individual of exclusion from refugee status and decisions on extradition is, however, the principle of non-refoulement.

The surface finishing technique called black oxidation is currently being used on thetool holders made of low alloyed tool steel produced by Sandvik Coromant. Blackoxidation isn?t considered a sufficient technique because it doesn?t make the toolholders look like the quality products that they actually are. The reasoning behind thisis that the tool holders can show signs of corrosion after prolonged storing times orin countries with high humidity and temperature. The corrosion doesn?t decrease thetool holders performance, but the customers might believe otherwise.

The financial result of a transfer of ownership or external sale is to a great extent depend-ent on how the transfer is implemented and how the tax rules apply. The applicability of the Swedish tax rules regarding transfer of ownership in closely held companies largely de-pends on the interpretation of the prerequisite, equal or similar activity, which can be found in section 57, clause 4 of the Swedish Income Tax Act.The ruling made by the Supreme Administrative Court in RÅ 2010 ref. 11 changed the concept of equal or similar activity. The ruling lead to that the shares in a closely held com-pany was qualified due to that the capital from the original company had been transferred to the operating company. According to the ruling the original company had been split into several companies, thus was the companies considered to carry out equal or similar activity.

Traditions are something that is very important to many people, Christmas is usually no exception. Christmas tree, Christmas ham, herring and candle lights are just as important as the advent candlestick. The advent candlestick help you get the Christmas feeling during the countdown. In this report the work with a new advent candlestick concept can be followed step by step.A lot of information was needed in the beginning. By doing some research, surveys and interviews the ground was established for further work.

This thesis describes the planning and development of a volume meter of pine and spruce cones. The product was designed and developed for Stigsjö Skog och Frö AB in Härnösand. It was developed taking into account a number of requirements set by the supervisor David Zetterlund. The main requirements were that the volume measurement would be fast and give accurate results. These are two requirements that are missing in today's volume measuring method which is very problematic for the company.The plant was visited several times in Härnösand, mainly to discuss the generated concepts with the supervisor and perform tests on the prototype.

Följande uppsats handlar om 40-talister som har börjat gå i pension och deras tankar och känslor inför att gå från yrkesroll till pensionärsroll. Uppsatsen syftar till att undersöka hur 40-talisters syn på sin egen pensionering ser ut idag. Vidare syftar uppsatsen till att undersöka om och i så fall hur deras syn skiljer sig åt jämfört mot tidigare generationers upplevelser av detta. Vår frågeställning lyder: Hur upplever åtta 40-talister sin roll och identitet som blivande pensionärer? Anser de att denna skiljer sig mot föregående generation? Utifrån en kvalitativ metod har tematiserade djupintervjuer genomförts.

This work has been to find out what attitude the boys have towards dancing. To gather material conducted interviews with four boys from Sweden and four boys from South Africa to examine the boy?s attitude towards dancing. I wanted answers if the gender, culture or generation has an effect on the boys' attitude to dance. Two interviews were made with a teacher in Sweden and one in South Africa, which had responsibility for dance lessons at the school.