This master?s thesis deals with integrating simulations using Agilents Electronic Design Automation tool ADS with customized Matlab scripts, for solving complex analog and digital radio architectures. In particular, it addresses Predistortion, realized in the digital domain, of power amplifiers, modeled in the analog domain. The former is implemented in Matlab while the latter is implemented in ADS. Two versions of integrating the two systems have been tested: 1) Iterative approach on sample basis and 2) Scheduled batch solution by matrix inversion.