This study was conducted at the University of Bath, UK, from September to December 2014 as part of an ongoing research project aimed at elucidating how the Grb10 gene might act as a mediator of long-term health effects (such as Predisposition to obesity, diabetes, coronary heart disease and hypertension) caused by environmental factors during development. This phenomenon is known as developmental programming. The purpose of this thesis was not primarily to answer any of the broader questions posed by this research project at large since this would require much more data than is reasonable to acquire over the course of a few months, but rather to evaluate the methods used in this project and reveal whether they are working the way they are presumed to. In the research project, which employs mice with the Grb10 gene knocked out as well as wild-type control mice, a dietary restriction model is utilized during gestation, which is supposed to generate offspring with lower birth weight and subsequent detrimental health effects in adulthood. This is supposed to be achieved by restricting the protein content of the pregnant mothers? diet to 9 % (as opposed to the control diet of 20 %) throughout gestation.

Stereotypier och tvångsbeteenden är relativt vanligt förekommande hos hundar. Exempel på några av dessa beteenden är flanksugning, filtsugning, slickdermatit, bita i luften, svansjakt och att stå som fastfrusen. Det finns oenigheter inom litteraturen om vad en stereotypi respektive ett tvångsbeteende är. Vissa författare använder begreppen som synonymer, medan andra ser det som två skilda beteenden. På grund av den rådande begreppsförvirringen använder jag termen avvikande repetitiva beteenden som ett samlingsnamn.