5-hydroxytryptamin (5-HT) is biochemically derived from Tryptophan. Kynurenic acid and quinolinic acid are also known metabolites of tryptophan. 5-HT is considered to play a role in depression and today selective serotonin reuptake inhibitors (SSRIs) are used for treatment of depression. 5-HT may also play a role in pain perception. The aim of this study was to investigate whether a supplement of tryptophan may affect conditions such as depression and/or pain.

Isaksson, H & Olsson, J. Upplevelse och behandling av postoperativ smärta. En litteraturstudie. Examensarbete i omvårdnad 15 högskolepoäng. Malmö högskola: Fakulteten för Hälsa och Samhälle, Institutionen för vårdvetenskap, 2012. Smärta är en upplevelse som är personlig och individuell.

Background: The majority of patients requiring medical attention experience some degree of pain. The nurses´ assessment of pain is crucial in reducing the patients suffering in a proper and timely manner. Previous studies have shown that the treatment of pain in a emergency situation is poorly managed. The patients´ pain experience is often under assessed and undertreated which leads to increased suffering for the patient. This results in higher costs for the health care system due to prolonged hospitalization.

AbstractAimThe aim of the pilot study was to compare short- and long-term effects from group exercise in water with land-based exercise on pain at rest and pain with movement, along with the effects on function in daily life and practice of sports and leisure activities in patients with knee osteoarthritis. The aims were: Is there a difference in short- and long-term effects on pain intensity at rest and pain with movement after exercise in water or land in patients with knee osteoarthritis? Is there a correlation between the degree of pain intensity at rest and with movement, respectively and long-term effects from the two different exercises on function in daily life and practice of sports and leisure? MethodThe study was a randomized intervention study without a control group. Twenty patients with radiographic knee osteoarthritis were under a total of eight weeks treated with either land- or water-based exercise lead by a physiotherapist. The patients rated pain intensity at rest and with movement on a numerical rating scale (NRS) before and after the first training session, before and after the eighth training session, before and after the fifteenth training session and before the last and sixteenth training session.

 The aim of the study was auditing medical records examine postoperative blood glucose levels after undergoing CABG surgery. Furthermore the aim was to determine if the ward staff abides the local guidelines frame of reference concerning each ward, regarding blood glucose measurements and blood glucose levels. The study included 70 patients undergoing CABG surgery at the cardiothoracic surgery, Uppsala University Hospital. The study was conducted by retrospective medical record auditing. Studied factors were postoperative blood glucose levels, number of registered blood glucose measurements, a current diagnosis of DM and preoperative HbA1c.

Syftet med denna studie är att utifrån ett föräldraperspektiv undersöka behov av och önskemål om stödsom föräldrar med diagnos inom autismspektrum beskriver i sin föräldraroll. Ett annat syfte är att bidra med ökad kunskaptill en diskussion kring utformandet av stödinsatser för dessa familjer. Studien är kvalitativ med intervjuer som gjorts ihalvstrukturerad form. Åtta föräldrar har intervjuats. Föräldrarna beskriver att deras svårigheter gör det svårt för dem isamspelet med barn och partner.

Vid operation av primär total höftplastik finns det olika metoder för postoperativ smärtlindring. En tidigare genomförd studie på ett mellansvenskt sjukhus (nedan kallad ?höftprojektet?) visade att ?Local infiltration analgesia? (LIA) initialt minskade postoperativ smärta, underlättade mobilisering samt förkortade vårdtiden, jämfört med spinalt morfin. I denna studie genomfördes en långtidsuppföljning av höftprojektet med mätningar efter 6 respektive 12 veckor. Studiegruppen hade fått LIA vid operationsslutet och kontrollgruppen spinalt morfin.

Opioids are considered the "golden standard" in pain management for both humans and small animals, but is used less often in equine medicine - probably for fear of side effects. Are there any studies that suggest that side effects are a major problem, or is it lack of experience which is the greatest obstacle to use? As early as 1937 it was shown that morphine and morphine derivatives provide analgesia in horses. For species other than horses used opioids often both pre-, intra-and postoperatively. They relieve pain effectively and are often included in the anesthesia protocol.

In this study, cortisol in saliva and pain related behaviours in calves were used as markers of distress when comparing two different dehorning methods; scoop or cautery. We also investigated the effect of a non steroidal anti-inflammatory drug (NSAID), meloxikam, on postoperative distress after dehorning with either dehorning scoop or cautery iron. Twenty calves were dehorned on one randomly chosen side by scoop method and on the other side by cautery. Five months later, the effect on horn growth was investigated. Horn production was observed in seven of the calves.

The aim of thie literature review was to study the advantages and disadventages of the intranasal medication, treating children with acute pain in  prehsopital settings and in emergency care. Searches were performed in databases PubMed and Cinahl. The intranasal method of administrating drugs could be a acceptable compliment to todays's traditional metods. Unnecessary pain is avoided as there is no need for skin penetration. Further studies are necessary in order to integrate this metod both in prehospital settings and in emeregncy care..

Deep vein thrombosis (DVT) is a serious postoperative complication and nurses should therefore observe symptoms in an early stage and implement preventive provisions, for example use of graduated compression stockings (GCS). The nurse is also responsible for making sure that ordinate GCS tried and used correctly by the patients. The aim of this study was to investigate the latest research regarding the efficacy of GCS in prevention of postoperative DVT and if there are any incorrectness in usage. And assess guidelines and recommendations for the usage of GCS. Method: Literature review.

 AbstractBackground: Among elderly people with dementia pain is a common problem. In older persons, particularly those suffering from dementia and cognitive impairment pain is often underdiagnosed and undertreated causing unnecessary pain, suffering and affect quality of life negatively. Dementia complicates the identification of pain when the natural ability to communicate decreases when a person is suffering from dementia. It is important that health professionals working with older persons with dementia are aware of the person?s pain expression.Aim: To clarify how older persons with dementia communicate pain expression.Method: To study this area a literature review was used.

Andréasson, M, Preoperativa förutsättningar och postoperativ smärta efter hysterektomi. Examensarbete i omvårdnad 15 högskolepoäng, avancerad nivå (105-120 hp). Malmö högskola: Hälsa och samhälle, Utbildningsområde omvårdnad, 2008. Syftet med studien var att undersöka hur 50 patienter bedömer den preoperativa fasen inför en planerad hysterektomi och att beskriva eventuella samband mellan dessa aspekter och upplevd postoperativ smärta. I studien användes ett frågeformulär med strukturerade frågor och ordinalskalor samt VAS verbala smärtskala för att värdera den pre- och postoperativa omvårdnaden. Studien visar att 18 (36 %) patienter hade postoperativt ingen till måttlig smärta och 32 (64 %) patienter hade medelsvår till outhärdlig smärta. Trots detta tyckte 36 (72 %) patienter att den postoperativa smärtlindringen var tillräcklig medan 13 (26 %) tyckte den var otillräcklig.

Bakgrund: Smärta är en individuell upplevelse som kan vara svår att förmedla till andra men är ett oundvikligt fenomen efter kirurgiska ingrepp. Sjuksköterskor ska utifrån ett helhetsperspektiv bedöma patientens postoperativa smärta. Studier visade att det finns en skillnad mellan sjuksköterskors bedömning och patienters upplevelse av smärta. Smärtbedömningen kan försvåras av flera faktorer.Syfte: Syftet med denna litteraturbaserade studie var att beskriva faktorer som påverkar sjuksköterskors bedömning av postoperativ smärta hos patienter. Metod: En litteraturöversikt som baserades på 15 kvalitetsgranskade och systematiskt valda vetenskapliga artiklar.Resultat: Patienterna upplevde att deras smärta ofta underskattades av sjuksköterskorna.

AimThe aim of the present study was to study possible evidence for shock wave therapy on pain and function in patients with plantar fasciitis.Questions1. Does shock wave therapy reduce pain in patients with plantar fasciitis?2. Does shock wave therapy improve function in patients with plantar fasciitis?MethodA systematic review of the literature was performed in the databases PubMed, EMBASE, Cochrane and Cinahl.