Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

This thesis describes a tool for data mining used to optimize ambulance preparedness. The goal with the tool was that it should be able to retract the information necessary to be able to analyze and calibrate the preparedness model used in the software ResQMap. ResQMap is used by SOS Alarm, who are responsible for the Swedish emergency number 112, as a decision support tool for ambulance operators. It is developed by Carmenta AB, who are the supervisors of the thesis work. Also, a minor study of the preparedness models variables has been performed in order to be able to evaluate the function of the tool.

There is an irregularity in the interregional migration in Sweden. An increasing proportion ofthe population is drawn to the metropolitan areas, which creates problems for the smallermunicipalities and towns when their population declines. At the same time, our whole societyis faced with a great challenge: we need to redirect towards a sustainable development, wherethe environmental issues are discussed and dealt with to secure that all present and futuregenerations are given equal opportunities to live a good life.The aim of this study is to, focusing mainly on the environmental dimension of thesustainability concept, examine the attractivity of housing with sustainability claims. Toanswer this, three research questions were used:? Was the migration motive to reduce their environmental impact a part of the decision tomove, among migrants who had moved to housing with sustainability claims?? If the motive was a part of the decision, how much impact did it have compared to othermigration motives?? Which factors in housing aiming at sustainability are considered important by peopleliving in housing with sustainability claims?The research questions have been answered using quantitative data, gained in the form of selfadministeredquestionnaires which were distributed in four different residential areas withsustainability claims in the county of Västra Götaland, Sweden.

Comfort analyses regarding human induced vibrationsIt is not too common among civil engineers in Sweden to perform comfort analyses considering the vibrations caused by human activities. In addition, the Swedish standards lack requirements to be used for comfort analyses in design of floor-systems. The demand for large spans in combination with slender slabs, is today a reason to investigate the floor-system constructions, in order to prevent disturbing vibrations and oscillations.The purpose of this thesis is to create a guide for how a comfort analysis, considering vibrations, should be implemented. Göran Svedenbjörk who is an expert in structural dynamics has been interviewed where he presents his latest project Värtaterminalen and answers some questions about vibrations due to human activities.Floor-systems, consisting of concrete slabs supported by steel or concrete beams, have been investigated with simulations in the finite element program Abaqus. In the simulations, the influence of various factors on the natural frequency of floor-systems and the acceleration level caused by dynamic loads, is studied.

This study focuses on the development of methods for sexual determination of human skeletal remains, mainly between the years 1981 to 2007. By comparing an older analysis from 1983 (Persson and Persson) with my own on the same material, a difference of 40% was shown, which indicates that the methods has changed through time, and that these should not be used for newer conclusions about a population if the method is not throughoutly described.The main cause of the difference was identified as a change in the reliability of the sexual indicators, rather than a total change of method. Any general tendencies did not show, it is however considered that the pelvic bones are able to make a better conformity between the analyses as opposed to using the cranium..

The Swedish Cellulosa Companiy, SCA, has today 280 000 ha planted with lodgepole pine (Pinus contorta var. latifolia) (?C?) which is equivalent to 14 % of its total forest area. Exotic lodgepole pine has in previous experimental stands shown a superior growth than the native Scots pine (Pinus sylvestris L.) (?S?).But also the comparison could be questioned because stand histories were was unknown and also differences in age between C and S existed.

Background: Investors have several options to choose from when the goal is to achieve the highest yield at the lowest cost and risk. Stocks are a common investment options, but is also associated with risks. Portfolios are usually constructed with several different assets to reduce the unsystematic risk of investment. Funds are similar to composite stock portfolios, the big difference is that they dealt with in their entirety and investors may not affect the fund's content. The problem remains that whether you choose stocks or mutual funds there is still uncertainty as to how the future will unfold.

Like many small-time companies there is a need to improve the flow of materials at HSP-Gripen AB. The company develops and manufactures hydraulic-powered grapples for the machine- and forest industry. By mapping the material flow in the current production and gathering necessary data, suggestions on how different parts of the production could be controlled is presented in this dissertation. This has been achieved by the study of relevant scientific literature. The suggested ways of controlling the production consist of 2-bin systems, hybrid material flow system as well as a cyclic product-planning.

Historically transformers with system earth equipment have been modeled as open circuits in zero sequence. This approximation has been satisfying, but lately it has been discovered that equipment on one side of the transformer have responded to faults that occurred at the other side. Most of these problems took place when the majority of the system on the secondary side of the transformer contained cables. These findings have led to questioning whether or not the former model of the transformer in zero sequence is correct. This report investigates if it is necessary to represent the transformer in zero sequence in another way than it is usually done today.

It is a well known archaeological concern that the remains of human bones left from the bronze age and early iron age Scandinavia are not nearly enough to represent the estimated population of the time. Furthermore the bones of each find rarely represent a whole individual. The majority of the bones must have been disposed of somewhere else, possibly scattered in running waters or in the fields, where they have evaporated or are securely hidden from archaeological excavations.This thesis deals with the grave concept and the problem in using a word that is so very clouded by its modern, western meaning. It also offers an alternative explanation to why the bones are handled the way they are and why they are found in such awkward contexts..

Today we can create digital 3D models which can be realised almost instantly through production methods such as 3D printing and computer controlled milling.What if this same technology could be applied to the development and construction of terrain parks?With snow as the material tools could be developed using similar principles to design and sculpt the surface, only on a larger scale.How would terrain park designers adapt their process to use this new technology? In this Industrial design thesis I explore how the ideas of the terrain park designer can be expressed through such a system with focus on the designers knowledge and skill without the need to learn complicated 3D programs.Sketch, create, ride. .

Many dairy farms doesn?t keep their bull calves and cross cow calves, they sell them to breeders instead of raising them their self. It should be possible for the dairy farmers to do it them self?s. There is also a possibility to bread one calf from the cross heifers. The purpose of the investigation was to see if there is any economic possibility to breed beef cattle. I have used the same sample farm trough the hole study, because it would be easier to fallow the study.

In this paper discourse analysis on the Ethiopian National Action Program (NAP) to combat desertification is made. The aim is to describe how the overall image/picture of desertification, its causes, and effects and of possible solutions are presented in the NAP. The result of this analysis shows that the main cause of desertification is human activities mainly due to the poorly developed socio-economic situation in the dryland areas. It is indicated that an excessive dependency of the rural population on the natural resources, particularly land, is the major cause of land degradation and this deterioration of land is said to have been caused by the rapid population growth, overgrazing, forest clearing as well as past government and institutional failures. In addition it is indicated that the effect of desertification usually involves ecological changes that sap land of its ability to sustain agriculture and human habitation, therefore the most serious threat to human welfare.

Around the world, forests are generally being fragmented and as plant populations decline in both sizeand number of individuals, the genetic variation will also decrease whitch in the end leads to totalextinction of the plant. In this paper, I wanted to investigate what specific species of trees and shrubsyou usually find in the edge and core habitats in some of the forests in the Baltic Sea region. I alsowanted to identify the edge effects and their sources and finally compare the results between thedifferent regions.The data sources used are derived from the ongoining research project Landscape structures, patterns ofbiodiversity and conservation strategies in the Baltic Sea region by Kari Lehtilä, Patrik Dinnétz ochTiina Vinter who have made a record of all herbaceous plant species in four randomly chosen forestregions situated around the Baltic Sea: Estonia, Skåne, Södermanland and Germany. I made statisticalanalyses, using the computer program R, concerning the distribution of species in the edge habitats ofthe forests as well as in the core habitats. I performed generalized linear models and then variationanalyses with the factors light and biomass in order to investigate wether edge effects might appear dueto these factors.

This c-level essay examines how deaf and hearing impaired individuals use smartphones to live and communicate in a ?hearing world?. The main target is to find some understanding of the struggles of this population and smartphones have made it easier to adapt to the hearing worlds? demands with the applications that follow. To acquire the information for this essay, representatives from both the deaf and hearing impaired communities were interviewed.