The problem of finding targeted medicine is a central problem in chemotherapy. From this point of view the ubiquitin-proteasome system is a highly promising object in the pharmaceutical approach. Proteasome plays a critical role in cellular protein degradation, cell cycle and apoptosis regulation.Proteasome inhibitors are substances blocking the actions of proteasome. Cancer cells are more sensitive to inhibition of the ubiquitin-proteasome system than normal cells. Therefore proteasome inhibitors have the potential to be successfully used in the cancer treatment.The study aimed to test various substances to identify possible proteasome inhibitors with the IncuCyteTM FLR image system and fluorometric microculture cytotoxicity assay.

The Swedish government published their current proposition concerning cultural politics,Tid för kultur in 2009. Due to this proposition, culture is considered a basic human right we all deserve to be provided with. It contained goals and guidelines for how to enable culture to all citizens, to integrate and enrich the state, the county councils? and municipalities? work with diversity and multi culture in their culture-based institutes. However, there seems to be a lack of strategies in the issue of how to provide our nondependent elderly, suffering age related handicaps and diseases, with this proclaimed necessity.In recent years, there has been a lot of research proving the link between human wellbeing and a stimulating environment.

The Swedish government published their current proposition concerning cultural politics,Tid för kultur in 2009. Due to this proposition, culture is considered a basic human right we all deserve to be provided with. It contained goals and guidelines for how to enable culture to all citizens, to integrate and enrich the state, the county councils? and municipalities? work with diversity and multi culture in their culture-based institutes. However, there seems to be a lack of strategies in the issue of how to provide our nondependent elderly, suffering age related handicaps and diseases, with this proclaimed necessity.In recent years, there has been a lot of research proving the link between human wellbeing and a stimulating environment.

The occurrence of small amounts of albumin in urine, microalbuminuria (MA), is used both in human- and veterinary medicine as an indicator for patients who have developing proteinuria. Proteinuria can be prerenal, renal or postrenal which is important to establish during an investigation. With conventional methods decreased renal function is not detected until 70 % of renal function is lost. The ability to detect and start a treatment earlier might reverse or slow the progression of disease. The purpose of this study was to investigate the reliability of Heska® E.R.D.-Health Screen?, a test for microalbuminuria in dogs, to detect albuminuria.

Bakgrund: Ca 10% av alla nyf?dda i Sverige v?rdas ?rligen p? en neonatalv?rdsavdelning, d?r separation mellan barn och f?r?ldrar ?r vanligt f?rekommande, trots evidens om dess negativa konsekvenser f?r b?de f?r?ldrar och barn. Nollseparation inneb?r att f?r?ldrar och barn h?lls i s? mycket fysisk och psykisk n?rhet under v?rdtiden som m?jligt. ?ven om tidigare forskning har belyst konsekvenserna av separation inom neonatalv?rden, finns begr?nsad sammanst?lld kunskap om hur f?r?ldrar upplever nollseparation i en neonatal kontext.

Svår sepsis och septisk chock är sjukdomstillstånd som kan orsaka ett stort lidande för patienten genom att de är förknippade med hög mortalitet och morbiditet. Tidig identifiering och adekvat antibiotikabehandling är avgörande för prognosen. Detta ställer höga krav på ambulanssjukvårdens kvalitet. Ambulanssjukvården har behandlingsriktlinjer som ska utgöra beslutsunderlag och kvalitetssäkring för den givna vården. De potentiella vinsterna med en behandlingsriktlinje blir dock aldrig bättre än kvaliteten på behandlingsriktlinjen i sig.

How can a vacuum cleaner motivate you to use it? From a sustainability perspective,the author asked the question of how such a solution would looklike? These where issues that the project tackled and devised solutions for. Theproject wanted to explore the physical modeling and a large part of the finalresult consisted of a full scale model. The project found that the problem ofvacuuming largely consisted of the problem of storage the product. The projectfound that the motivation for the job, therefore, could be resolved by a betterdesigned vacuum cleaner with a built-in hose, folding handles, which couldbe stored integrated within the vacuum cleaner.

The company Betsson opened its first physical gambling shop in Sweden in May 2008, thereby defying the Swedish government?s legal gambling monopoly. The legal case that has resulted due to the violation of the Swedish gambling law has attracted immense attention from mass media, thus generating vast amounts of publicity for the company. This paper aims to evaluate and describe the company?s decision to open the store, as well as to examine the relationship between market driving practices and market driven practices.

The project concerns a predevelopment work for Scania AB, a leading manufacturer of heavytrucks, and was performed as a master thesis work for the program Design and ProductDevelopment at KTH. The purpose of this work was to examine how the work situation of truckdrivers, especially long-haulage drivers, can be improved with respect to prolonged sedentaryoccupation. Mental fatigue and under-stimulation due to low cognitive load during long drivescan be major risk factors for traffic accidents. Physical strain injuries to both the skeleton andmuscles are common for this working group and minimal opportunity for daily exercise alsoincreases the risk of developing blood clots in the legs, which can have serious consequences forthe driver's health.An extensive background study, both theoretical and exploratory, was performed to identify thedrivers' concerns and comfort needs. Various treatments such as massage and active sitting wereinvestigated and existing products within the area studied.

The aim of this study is to observe Swedish preschool children in their natural habitat and without any intervention. Four different observations are made and thereafter analyzed. Throughout the whole study the subject of interest is the children's communication in their play. Children can communicate with each other in various ways, for instance with speech and without speech, i.e. with their physical language, aesthetic and multi language.

It is important to know what is normal in the wound healing process in order to determine what happens when a wound does not heal as expected. If the amount of bacteria in the wound gets too large the body will not be able to defend itself and it becomes an infection. Colonization and infection are common elements in wound management and it is often the veterinary nurse role to deal with wounds in a proper manner. Antibiotics are drugs that either kill or inhibit the multiplication of bacteria or fungi, and have been in veterinary medicine for approximately 60 years. Very few new antibiotics are introduced and increased resistance is a major problem that requires everyone to take responsibility to reduce the use of it.

The Swedish way to organize sport has a long tradition and the parents play an important role in ways to organize sport. Without the thousands of adults who voluntary work the sport associations would have problems to survive. However, there are tendencies to that commitment is reduced, which means that the activity is exposed. The purpose of this study was to examine parents opinions about a nonprofit children´s sport respective professional children´s sport. The study was based on questionnaires which were distributed to 83 parents in four different sports; equestrian sport, track and field sports, ice hockey and soccer.

Målsättningen med detta arbete är att ta fram en metod för att kartera och analysera den rumsliga variationen av landskapets sårbarhet för miljögifter, samt att visa hur geografiska informationssystem (GIS) kan underlätta denna rumsliga kartering och analys. Analysen utfördes inom vattenskyddsområdet Ignaberga-Hässleholm i Hässleholms kommun. Först studerades sårbarheten utifrån markens förutsättningar med hjälp av modellen DRASTIC och sedan studerades var de mest mobila bekämpningsmedlen har använts i förhållande till resultaten från DRASTIC..

Gotland is famous around the world for its unique nature. The agriculture here has always been an important source of income and part of the identity of the island. But today the profession has low status and hard to survive. How can the interest for farming be increased?Gotlandsgården is an investigation about how the agriculture could develop.

The purpose of this paper is to examine the law regarding gross violations of women and its application in the Swedish legal system. We have investigated how the legal system takes into account a holistic perspective of the vulnerable situation of women in the investigation and assessment and the extent to which psychological violence in the form of verbal abuse, threats and harassment attention. We also wanted to find out how the law's design may contribute to difficulties in the implementation and interpretation of it. In this study, we used a qualitative research approach when we decided to conduct an interview with a police officer and a textual analysis of four cases from the district court. Interview questions were semi-structured in order to gain a deeper understanding of the phenomenon.