The development of quantitative, real-time PCR (qPCR) combined with the mapping of the canine genome opens new possibilities in veterinary medicine. This method provides a quick and accurate quantification of the expression of a specific gene at a given point in time and thereby also information of how the gene expression for a certain protein is influenced by various conditions and diseases. One possible area of application is identifying bio markers for cancer. Recently the protein serglycin (the core protein of an intracellular proteoglycan) was found to act as a selective marker for the disease acute myeloid leukemia in humans (Niemann et al, 2007). Serglycin is produced by most hematopoietic cells, although mast cells account for the largest amount of serglycin.

Bovine Respiratory Syncytial Virus (BRSV) is a common cause of respiratory disease among young cattle. The virus causes severe losses; the herd mortality rate can sometimes be as high as 20 %. In this study the avidity (i.e the antigen binding force) of BRSV specific antibodies was measured to see if there was a difference between antibodies produced during an acute phase of infection and antibodies produced by earlier infected animals. A commercially available ELISA-testkit against BRSV-specific antibodies was used and an incubation step with 6M urea was added. The effect of the urea is that it breaks the weak bonds between antibodies and antigen while the stronger bonds remain intact. Four different groups of animals were included in this study; seven calves that were naturally infected, three acutely infected calves with known time of infection, five cows that were seropositive during several years and four experimentally infected calves that had been a part of a vaccine trial. The results of this study showed that antibodies produced during the acute phase of an infection had a low avidity and that the avidity increased with time after infection.

Mastitis in dairy cows is an emerging and challenging disease in the tropics, including India. Nation-wide reports suggest that the incidence of clinical mastitis varies from 3.94% to 23.25%, and for subclinical mastitis from 15.78% to 81.60%. In Assam, a northeastern province of India, dairy is an essential part of the mixed farming system that exists in the state, but the milk yield is far below domestic standards. In 2009-2010, International Livestock Research Institute (ILRI) and local associates started to develop a training program for local farmers in Assam, in order to enhance the informal bovine dairy sector in and around Guwahati, India. The project continued until mid-2013.

Several factors affect the heifer´s growth and development, the newborn calf´s feeding of co-lostrum during its first hours of life is one important factor. The colostrum contains higher amount of immunoglobulins and insulin growth factors compared to matured milk. A high intake of immunoglobulins from colostrum results in a high blood concentration of immuno-globulins until the age of eight months. This leads to a lower incidence of diseases that can affect the growth and development negatively. Diarrhea is the most common disease in calves younger than 30 days.

I Sverige finns en hög frekvens av rotfyllda tänder med apikal parodontit och en praxis för behandling saknas. Denna studie syftar till att röntgenologiskt kartlägga progressionen av apikal parodontit vid rotfyllda tänder som ej blivit föremål för ytterligare endodontisk eller kirurgisk behandling och att identifiera variabler som påverkar progressionen för att ge ett bättre underlag för behandlingsbeslut. Röntgenbilder på rotfyllda tänder med apikal parodontit som lämnats utan åtgärd (n = 120) granskades avseende förändringen av den apikala parodontiten under minst en 3-års period under åren 2002-2011. Progression av den apikala parodontiten observerades i 22,5% av de studerade tänderna, trots att man sannolikt tidigare bedömt att den apika parodontiten inte behövde behandling eller att man kunde avvakta med behandling. Ingen av de studerade variablerna: den ursprungliga apikala parodontitens storlek, rotfyllningens längd, rotfyllningens täthet, typ av koronal restaurering eller den koronala restaureringens täthet befanns ha något samband med den apikal parodontitens progression.

Bakgrund: Perifer venkateter (PVK) är en allmän och rutinmässig åtgärd inom hälso- och sjukvården för att kunna lindra, bota och behandla genom att tillföra infusioner, läkemedel eller för att hålla en fri venväg. PVK består av ett främmande material som i kontakt med blod kan leda till att komplikationer som tromboflebiter bildas. Vid minsta tecken på rodnad, ömhet, svullnad, tromboflebit eller extravasation ska PVK avlägsnas. Syfte: Studiens syfte var att beskriva de senaste forskningsrönen kring sjuksköterskans omvårdnadsåtgärder för att undvika PVK-relaterade komplikationer. Metod: Studien är en litteraturstudie där resultatet baserats på kvantitativa och kvalitativa artiklar.

Acute bacterial prostatitis is a common disease in older male dogs. It gives symptoms such as fever, pain, tiredness, infertility, unwillingness to mate and sometimes symptoms from the urinary tract. It is common that you do an ultrasound exam on dogs when you suspect prostatic changes. In this study 15 dogs diagnosed with acute prostatitis at the small animal clinic at SLU in Uppsala were examined. The clinical signs and the ultrasound pictures were put together in retrospect.

About 35 years ago the WHO advocated that countries with injecting drug users should introduce the so-called needle exchange programs (NEP) to curb the spread of infection by blood-borne diseases. In Sweden the first NEP started 1985 in Lund, but the program was extremely controversial in a country with such a restrictive drug policy like Sweden.The study you are about to read shall process this controversy, when a NEP opened in Stockholm, by analyzing the articles published in the newspapers Dagens Nyheter and Svenska Dagbladet. By using discourse analysis as a processing tool we?ll try to see the difference between the two chosen newspapers. We will identify and analyze the different participant?s, such as doctors, politicians, user associations and media, arguments in the needle exchange issue.

Exoner är de sekvenser i DNA vilka rymmer koden för proteiner i människan och i alla andra organismer. Intronerna, vilka utgör utrymmet mellan exoner, består av ickekodande sekvenser och kontrollelement. Exoner tillhörande en gen måste inte alltid inkluderas i den slutliga mRNA produkten, alternativ splicing tillåter exkludering av vissa sekvenser och gör att en gen kan ha mer än en mRNA produkt, därigenom kan en gen koda för flera olika proteiner. Alternativ splicing är ett fält som snabbt utvecklas och dess relevans för många sjukdomar har blivit uppenbar. Detta arbete går igenom ett flertal av dessa sjukdomar för att sammanställa ny forskning och tydliggöra rollen av alternativ splicing i dem.

Alzheimers sjukdom är mycket vanligt förekommande sett ur både ett internationellt och nationellt perspektiv. Ungefär 90 000 personer har diagnosen Alzheimers i Sverige. För att sjuksköterskan ska kunna ge god och adekvat vård behöver patientens upplevelse av sjukdomen uppmärksammas. Syftet med denna studie var att belysa patientens upplevelse av första fasen vid Alzheimers sjukdom. Studien genomfördes som en litteraturöversikt där tolv vetenskapliga artiklar bearbetades och analyserades för att sedan utgöra resultatet.

Bakgrunden till studien bygger på ett samarbete mellan sjukgymnastprogrammet på Mälardalens högskola och ett sjukhus i Sörmlands läns landsting. Syftet var att utvärdera om behandling bestående av fyra veckors KOL-skola haft effekt på patienternas hälsa, välbefinnande och fysiska kapacitet. KOL-skolan bestod utav fyra tillfällen under vilka olika vårdprofessioner gav patienterna information om bl.a. symptompåverkan, känslomässiga upplevelser och vikten av fysisk aktivitet. Det var tio patienter med kronisk obstruktiv lungsjukdom (KOL) i stadium två till fyra som deltog i interventionen.

The world?s population reached more than 6.9 billion people in July 2011. It is expected that the population growth during the next 40 years will take place mostly in low-income countries and the population increase will be 2.3 billion people during 2011-2050. A rapid urbanization is also expected to result in 57.7 per cent of Africa?s population living in urban areas in 2050.

The Swine flu (H1N1) erupted in 2009 and wasquickly spread over the world and developed into a pandemic, with a great threat against people?s health. It was soon discovered that the H1N1?virus had a different character than the seasonal flu, since it especially affected younger individuals and the consequences from the disease were expected to be more severe. In Sweden it was decided to provide a free of charge vaccination against the H1N1-virus, and the Swedish vaccination ratiobecome relatively high compared to other countries.

Background: Ovarian cancer affects many women worldwide. Tumors that grow in the genitalia and pelvis have because of its placement a large threat to the sexual ability. Treatment for ovarian cancer may lead to the sexual possibilities inhibited. Sexual health is a state of physical, mental, emotional and social well-being related to sexuality. Sexual health can be experienced in spite of disease, dysfunction or infirmity.

Actinomycosis is a rare, deep-seated infection of the jaw of cattle that include the progressive enlargement of bone structures. It is caused by Actinomyces bovis, a gram-positive rod found as a normal commensal of the alimentary canal in otherwise healthy animals. This paper shortly describes Actinomyces bovis and its ability to cause "lumpy jaw" or actinomycosis in cattle. It will describe its pathogenesis, diagnosis, treatment and some clinical presentations. The incidence of symptomatic actinomycosis infection is quite low in Sweden today.