Cirka 300 000 individer drabbas årligen i världen av oral cancer och mer än nittio procent av alla orala cancerformer utgörs av skivepitelcancer. Den femåriga prognosen är generellt 50 % och den 5-åriga relativa överlevnaden har under en tioårsperiod förblivit densamma. Detta motiverar utvecklingen av bättre prognostiska markörer och diagnostiska metoder för att tidigt identifiera de patienter som har risk att utveckla oral skivepitelcancer för att förbättra prognosen och minska lidandet genom tidig insatt behandling. ?-catenin är en adhesionsmolekyl som är viktig för bibehållandet av cellulär integration och avvikelser i celladhesionsmolekyler tros spela en central roll när tumörceller invaderar närliggande vävnad det vill säga metastaserar till andra organ. Syftet med studien är att med hjälp av immunohistokemi undersöka om ?-catenin kan fungera som en prognostisk markör för utvecklingen av oral skivepitelcancer.

In this essay dog as a compatible model were put against human. The major histocompatibility complex (MHC) genes were compared between dogs, human, cat and mouse. To evaluate dog as a model and study similarities and differences was the aim with this review. Dog as a model contributes to understand mechanisms behind autoimmune diseases and showed clearly histological similarities between human and dogs concerning the skin disease mucous membrane pemphigoid (MMP)/cicatricial pemphgioid (CP). Further genetic evidence motivated the choice of using dog as a comprehensive model when the MHC-complex correlated with hypothyroiditis in Doberman dog as it does in human. Physiological similarities with low levels of thyroid hormones (T3 and T4) together with high level of thyroid releasing hormone (TSH) were found in the same way as in human.

Title: How do you get a pupil from Year 7-9 in secondary school to communicate in German?  Five high school teachers views on how to develop pupils oral communicative skill within the German language The aim of this essay is to explore Swedish secondary school teachers, from Year 7-9 in the German language, opinions regarding which work models and verbal strategies that are used and taught in order to foster the pupils oral communicative skill in the classroom. To achieve this aim, semi-structured interviews with five teachers are used.The results show that the teachers find that they encourage the pupils to speak German through creating possibilities for them to practise their oral language skills. The teachers also emphasize that they believe that alternating assignments in groups or pairs, where the students get the chance to be creative, activates the pupils to speak German the most. They also express an awareness for the fact that open or information questions encourage the pupils to use their creativity and speak more German.

Syftet med studien var att belysa hur patienter som strålats mot huvud- och halscancer upplevde sin orala hälsa efter avslutad strålbehandling. Studien är kvalitativ och består av intervjuer med åtta informanter. Intervjuerna har utförts med hjälp av en intervjuguide. Intervjuerna spelades in på bandspelare och varade i ca 10-20 minuter. Intervjumaterialet har analyserats med en kvalitativ innehållsanalys.

Obesity is a problem that increases exponentially in humans and companion animals. It is defined as a big accumulation of fat in the body and is usually connected with several diseases. This study describes how obesity can be diagnosed, in which way the gut flora can affect obesity, if the gut flora is genetically influenced or not, and how it differs between individuals with obesity and obesity-related diseases. Conclusions of the study are that both the bacterial strains Bacteriodetes and Firmicutes probably have a connection to obesity. The intestinal flora is probably also genetically related.

Syftet med denna studie är att undersöka olika salutogenetiska aspekter för friska äldre och undersöka om dessa kan implementeras i ett preventivt arbete i yngre åldrar. Material och metod: Sökning gjordes i databasen Pubmed. Alla artiklar som uppfyllde inklusionskriterierna och var relevanta för frågeställningen lästes i fulltext. Dessa blev kvalitetsgranskade och sammanfattades i en tabell. Kvalitetsbedömningen skedde med hjälp av en checklista som kan användas för bedömning av både randomiserade och icke-randomiserade kliniska studier. Resultat: Efter sökningen i Pubmed och läsning samt granskning av artiklar inkluderades 29 artiklar.

The aim of the study was to assess the speech outcome in children with cleft palate operated with the Gothenburg Technique at Maria Sklodowska Curie Children?s Hospital. Eighteen participants with unilateral cleft lip palate were recorded and assessed through a single word test. Percent consonants correct and cleft speech characteristics were calculated after phonetic transcription. Intelligibility ratings and velopharyngeal composite scores were reported.

ABSTRACTWhat kind of information and instructions with the consideration to diagnosis do patients, treated by the dental hygienist students at the University Kristianstad, get regarding oral hygiene, diet, flour and tobacco.The aim of this study was to examine what kind of information and instructions regarding oral hygiene, diet, flour and tobacco have patients treated by the dental hygienist students at the University Kristianstad, if they had the diagnosis caries or periodontitis. The study is based on a review of dental records of adult patients from twenty years on a supportive treatment program. In all 640 patients were enrolled at the clinic, 20050309. A selection of 100 patients treated at the clinic from 2000 was made. Fifty off the dental records should have the diagnosis caries and fifty the diagnosis periodontitis.

Our companion animals can, with or without symptoms, carry infectious agents which have a potential to induce diseases in man, so called zoonoses. An immune compromised person has an increased risk of becoming infected by various agents, and thus also has an increased risk to become infected by one?s own companion animals. A study was carried out within the veterinary program at SLU, Sweden, based on a questionnaire answered by 31 physicians, 31 veterinarians and interviews of 30 immune compromised persons in Sweden. The study investigated the following questions: Which zoonoses do physicians and veterinarians consider to be the most important to inform immunecompromised persons about? How are immunecompromised persons being informed by their physicians about the risk of catching zoonoses from their companion animals? How are the owners of zoonosis-infected animals being informed by their veterinarians about zoonoses? Does veterinary medicine and human medicine communicate about zoonoses, in order to take the best care of immunecompromised persons in contact with animals? The results of our study imply that: - Physicians and veterinarians differ about which zoonoses immunecompromised persons should be informed about. - Only oral information is passed to immunecompromised persons and animal owners.

Användningen av per oral cancerbehandling har ökat de senaste åren. Per oral cancerbehandling är inte automatiskt förknippat med samma strikta riktlinjer som vid intravenös behandling, däremot så är biverkningsprofilen med allvarliga och ibland livshotande tillstånd i stort sett densamma. Forskning har visat att följsamheten till den per orala cancerbehandlingen varierar, ibland är låg och inte är bättre än andra kroniskt sjuka gruppers följsamhet. Patienten sköter till stor del behandlingen själv. Konsekvenserna av detta kan vara ett försämrat behandlingsresultat, risk för över resp.

Emerging infectious diseases are a recurring threat to both human and animal health. Understanding the multiple causes behind the emergence of new diseases is key to the prevention of new and potentially devastating outbreaks. The list of underlying causes is long, including a variety of anthropogenic, environmental, molecular and climatic changes that promote the emergence and spread of disease. Two of these factors are central to the emergence of new diseases and receive special attention in this study. The spread of disease from wildlife to livestock and diseases that spread from animals to humans (zoonoses) are of importance as they implicated in the majority of EID events.

Introduktion: Sjögrens syndrom (Ss) är en kronisk reumatisk sjukdom som förstör de exokrina körtlarna i kroppen. Detta leder till minskad salivproduktion. Nio av tio av de drabbade är kvinnor i medelåldern. Sjukdomen finns som primär Ss och som sekundär Ss. I dagsläget finns inget botemedel mot sjukdomen därför riktar sig behandlingen mot att lindra symtomen.

The aim of this study is to investigate oral peer review on argumentative speech and to study the attitudes towards this peer review. The investigation was performed in an up-per secondary school class, and it focused on the different types of oral responses students give each other. In addition, the study investigated in what way the students experience this type of peer review. The results show that students reflect on form and performance as well as content, but they place more emphasis on form and performance than content. Students are positive about peer review and its importance for their progress.

Actinomycosis is a rare, deep-seated infection of the jaw of cattle that include the progressive enlargement of bone structures. It is caused by Actinomyces bovis, a gram-positive rod found as a normal commensal of the alimentary canal in otherwise healthy animals. This paper shortly describes Actinomyces bovis and its ability to cause "lumpy jaw" or actinomycosis in cattle. It will describe its pathogenesis, diagnosis, treatment and some clinical presentations. The incidence of symptomatic actinomycosis infection is quite low in Sweden today.

Riskbedömning är en väsentlig del av klinikerns vardag. Varje patient ska riskbedömas och riskgrupperas, vilket sedan utgör grund för val av behandling, behandlare och revisionsintervall. I tandvården i Sverige idag används det ett flertal olika stödsystem eller riktlinjer för riskbedömning av oral hälsa. Syftet med studien var att ta reda på vilka stödsystem/riktlinjer som finns för riskbedömning av oral hälsa i Sverige idag och ge en beskrivning av de mest frekvent använda systemen samt göra en jämförelse av dessa. Syftet var också att undersöka huruvida dessa system är evidensbaserade och utvärderade samt att kartlägga kunskapsläget, gällande evidensbasering och utvärdering av stödsystem/riktlinjer, för riskbedömning av oral hälsa.