The ability to detect protein-based biomarkers, which are linked to different diseases like colorectal cancer, is very important as a diagnostic tool. Usually complex biological samples like blood are studied which will contribute to different technical issues when performing an assay. The aim with the project is to optimize and develop the high throughput protein detection technique Proximity Extension Assay, PEA, into a 96-plex panel, in hopes of discovering an expression profile for colorectal cancer. PEA was developed by Olink Bioscience and allows specific proteins in a sample to be quantitatively transformed into nucleic acid sequences that are subsequently detected and quantified with real-time PCR. Two proximity probes containing oligonucleotide sequences bind pairwise to target protein and when brought in proximity, a DNA polymerase will extend a hybridization arm from one probe over to the second forming a double-stranded DNA sequence that can serve as a template in real-time PCR.

The BSC is widely used mangement tool that is turning the vision and strategy into operational goals. However, after analyzing the criticism received the BSC, it seems af its internal focus, rigidity, static-ism and mechanical mindset limits the company's ability to create a strategy that takes important external factros into account..

As a result of global competition, companies within the automotive industry are required to improve their production systems to achieve sustainable and competitive production. To attain operational excellence, companies have adopted concepts like lean and World Class Manufacturing (WCM).In order to deliver, companies need to increase the availability and reliability of production equipment. This demands focus on both operational and strategic maintenance, and efficient equipment acquisition and management. The main objective of this thesis is to identify processes and success factors that are necessary for improved maintenance performance. By conducting a case study and by performing a literature review, the following has been studied: 1) how companies within the automotive industry work with maintenance and maintenance strategies, 2) implementation of maintenance strategies, and 3) new acquisition and spare parts management for maintenance. The results show that basic maintenance concepts and related terms are well defined in the literature.

Direkt viktoptimering (Direct Weight Optimization, DWO) är en ickeparamterisk systemidentifieringsmetod. DWO bygger på att man skattar ett funktionsvärde i en viss punkt genom en viktad summa av mätvärden, där vikterna optimeras fram. Det faktum att DWO har en inparameter som man måste veta i förväg leder till att man på något sätt vill skatta denna inparameter. Det finns många sätt man kan göra denna skattning på men det centrala i denna uppsats är att skatta inparametern lokalt. Fördelen med detta är att metoden anpassar sig om till exempel systemet ändrar beteende från att variera långsamt till att variera snabbare.

Problem discussion: Syncron experience a challenge in realizing the full market potential of its newly developed IT-based price management system, Global Price Management (GPM). The system has already been implemented and is currently running with success within the IT-structures of the first customer. The fact that the development of the system has been initiated by a customer, and thereby has left Syncron oblivious of the real underlying drivers and incentives for the development, is part of the problem. Understanding the customers? incentives for developing their pricing process thus reducing the application uncertainty is a good starting point.

Background: As companies are operating in more globally and complex environments, the need for risk control is accelerating. In an ever-changing environment, companies cannot merely focus on traditional risks, which include financial and insurable risks. To maintain competitiveness, companies need to extend their risk management to include all risks, traditional as well as operational and strategic risks. Purpose: The purpose is to describe and position risk management for Telecom operators, in comparison with the risk management literature, with regards to structure, processes, learning process, visions and benefits. In addition, our aim is to link risk management perspectives with the different strategies for knowledge management.

The research objective of this thesis was to conduct a holistic evaluation of an operational information system. By holistic evaluation we mean that an equal focus was placed on both the system system perspective and its users user perspective, in the actual environment where the system and its users function contextuality. In addition, the methodological objective of the study was to test a new research approach in a real life setting. The participants of the study were twenty newspaper journalists employed at Göteborgs-Posten GP. The information system NewsLink is a manually indexed full-text database containing all articles published in GP since 1994.

Presently Sjöfartsverket do their maintenance according to a standard program, which means that every maintenance task will be done when the task limit occurs. This leads to a very long downtime for the aircraft in some occasions and very short downtime in others. The goal with this work is to reach a higher regularity of the aircraft operation. To reach a higher regularity for the operational needs, this work will present a hypothetic better maintenance concept for Swedish Maritime Administration. The concept is based on equalized maintenance structure, which means that every maintenance occasions are meant to take the same time to perform.

From underwater boat to submarine ? The development of the Swedish submarine service 1945-1960 The scope of this essay is the development of the Swedish submarine service during the period 1945-1960. The aim is to answer the following questions:- What kind of new technology did Sweden acquire when salvaging the German type XXI submarine off Gothenburg at the end of World War II?- In what respect did this technology differ from that of the Royal Swedish Navy and did it subsequently contribute to the tactical and operational development?- What tactical and operational development was accomplished between 1945-1960?The timeframe, 1945-1960, was chosen since this is when the analysis of the salvaged type XXI submarine and related effects was conducted. Furthermore, it is also during this time that the Swedish submarine service is beginning to evolve as a result of the new knowledge mentioned above and the experiences made by both the allies and the Germans during World War II.The theoretical framework primarily refers to the theories on naval warfare by Sir Julian Corbett.

SammandragStudien omfattar ämnesområdena operativ miljö i instabila stater, tillsammans med militär operativ och taktisk logistik. Eftersom den operativa miljön och också syftet med det militära maktmedlet i viktiga avseenden är särskiljande vid stabiliseringsoperationer, i jämförelse med reguljär krigföring, innebär detta att även anpassningsbehoven för logistiken förändras.Syftet med studien är att beskriva och analysera hur logistik kan utformas vid stabiliseringsoperationer, för att därefter teoretiskt bidra till en logistik som är anpassad för de generiska dragen i denna typ av operativ miljö.Empirin till studien är framtagen från västerländska operativa och taktiska stabiliseringsdoktriner och teorin är hämtad från Moshe Kress Operational Logistics. Analysen genomförs med ett logistiksystems operationaliserade kriterier, och redovisar de framträdande anpassningsbehoven för varje skede i operationen.Resultatet visar att det framträdande behovet är att säkerställa kontinuitet i flödet, vilket förutsätter operativ flexibilitet. Undantaget är Secure-skedet där tillgänglighet, som i sin tur förutsätter överlevnadsförmåga, är det framträdande för att optimera logistiksystemet. En viktig slutsats är att Hold-skedet sannolikt innebär störst behov av anpassning och kapacitet i ett operativt logistiksystem, sett till operationen som helhet.Nyckelord: Stabiliseringsoperation, operativ miljö, logistik, Comprehensive Approach Antal ord: 17967 (18192).

I got a request from Eleiko Sport AB regarding them needing help with trying to improve one of their products. The following examination project includes the principal- and primary construction reports within trying to make some improvements and optimizations on a stand for Kettle bells. I have in this project both made my own proposals to the stands legs, proposals on how to strengthen the shelf and also made an optimization of the original Kettle bell-stand. In this report, the project goes from idea to being built and analyzed in Catia, including the creation of drawings and material definition..

From underwater boat to submarine ? The development of the Swedish submarine service 1945-1960 The scope of this essay is the development of the Swedish submarine service during the period 1945-1960. The aim is to answer the following questions:- What kind of new technology did Sweden acquire when salvaging the German type XXI submarine off Gothenburg at the end of World War II?- In what respect did this technology differ from that of the Royal Swedish Navy and did it subsequently contribute to the tactical and operational development?- What tactical and operational development was accomplished between 1945-1960?The timeframe, 1945-1960, was chosen since this is when the analysis of the salvaged type XXI submarine and related effects was conducted. Furthermore, it is also during this time that the Swedish submarine service is beginning to evolve as a result of the new knowledge mentioned above and the experiences made by both the allies and the Germans during World War II.The theoretical framework primarily refers to the theories on naval warfare by Sir Julian Corbett.

Background: Risk Management plays an important part of the enterprises strategic business activity. Efficient Risk Management will secure the businesses survival, assets and creates market advantages. The interest of information security has consequently gained in Swedish corporations. Corporations have realized the importance of the information which is stored in the IT systems. IT is the tool for businesses future progress and growth and therefore a source of risks.

Biogas is a renewable energy produced through anaerobic digestion, which means that organic matter is degraded by microorganisms under anaerobic conditions. The produced biogas can then be used for cogeneration, electricity, heat or upgraded to vehicle gas. Eskilstuna Energy & Environment AB has four digesters at Ekeby water sewage treatment plant, Eskilstuna. One of the biogas reactor (RK4) is equipped with a jet-mixing system while the remaining digester uses top-mixing. The mixing system is an important parameter to achieve optimum operating conditions for the process regarding gas production and degree of digestion.

Åfors glasswork was a company which started in 1876 and closed in 2012 due to the bad economical situation in the company. After its closure, the glasswork left behind contaminated soil with different concentrations of heavy metals such as, arsenic from arsenic trioxide, a chemical used to remove bubbles during the melting of glass, and lead oxide, a chemical used in the production of crystal glass. Crystal glass?s production occurred under 1921-1971, but emissions of lead into the air from Åfors glasswork continued until 2011, because of the artist Bertil Valliens? artglas was made in Åfors glasswork from 1970?s and onwards.The aim of this study was to estimate how much lead (Pb) and arsenic (As) that were released by Åfors Glasswork into the atmosphere during the operational period of the glasswork in comparison with how much of lead and arsenic were purchased for the company. Added to the assistance of the data from National Archives the variations in the activities of Åfors glasswork could be shown.