Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

The present study examines the effect of a nine-hour Acceptance and Commitment Training (ACT) intervention for teachers who experience stress. Twenty-two teachers from four different counties in southern Sweden were randomly allocated to an ACT intervention (n=15) and a control group (n=7). The ACT condition received three three-hour sessions of ACT over a six-week period, and the control group received a three-hour stress lecture at one occasion. At a follow-up four-weeks after completed intervention, ACT participants showed significant in-group differences on stress, psychological flexibility, general health, and burnout. At a between group comparison, only psychological flexibility was significantly enhanced at the follow-up.

I denna uppsats undersöks hur psykologens yrkesroll formas och utformas på vårdcentral. Det empiriska materialet utgörs av semistrukturerade intervjuer med fem psykologer på vårdcentral, deras verksamhetschefer samt en yrkesutvecklingskoordinator för psykologer inom primärvården. Med utgångspunkt i grounded theory har resultatet analyserats i termer av primärvårdspsykologi, professionell identitet och professionssociologi. Resultatet lyfter fram psykologernas bild av sin yrkesroll, deras upplevelse av relationer till andra i organisationen och till gränsfrågor. Slutsatsen är att psykologens yrkesroll på vårdcentralen befinner sig i jurisdiktionens gränsområde och innebär ett aktivt identitetsarbete, en komplex och dynamisk process i spänningsfältet mellan professionella identitetsideal och organisatorisk reglering..

The main aim of the study was to examine the importance of organizational climate for affective job-related wellbeing. A further aim was to investigate potential differences in employee level in the experience of organizational climate and wellbeing. Another purpose was to see if there was agreement in the view of the organizational climate among the employees. Questionnaires were collected from 44 employees at a chain store. Results showed that Integration, Involvement, Supervisory Support, Training, Welfare, Innovation and Flexibility, Goal Clarity, Efficiency, Effort, Performance Feedback, Pressure to Produce and Quality had a great influence on Enthusiasm but only Pressure to Produce and Welfare correlated with Anxiety.

Bakgrund: Crohns sjukdom och ulcerös kolit är två huvudtyper som utmärker inflammatorisk tarmsjukdom. Inflammatorisk tarmsjukdom påverkar mag- och tarmkanalen och har ett oförutsägbart sjukdomsförlopp. Inflammatorisk tarmsjukdom debuterar vanligtvis i åldern 15-30 och kan ge ogynnsamma konsekvenser i personens dagliga aktiviteter eftersom han eller hon är upptagen med att exempelvis studera, skapa karriär eller bilda familj. Sjukdomarna har flera gemensamma särdrag där de förekommer i så kallade skov med perioder med försämring då tarmslemhinnan blir inflammerad och sårig, vilket leder till symtom som exempelvis blodiga eller slemmiga diarréer, viktnedgång, buksmärtor och trötthetSyfte: Syftet med uppsatsen är att beskriva konsekvenser av att leva med Crohns sjukdom eller Ulcerös kolit hos vuxna personer.Metod: En litteraturöversikt. En litteratursökning gjordes som ledde till sex granskade artiklar.

Syftet med denna studie var att beskriva arbetsterapeuters erfarenheter av att arbeta i ett team med rehabilitering av vuxna med en förvärvad hjärnskada. Sex arbetsterapeuter verksamma på rehabiliteringskliniker i Västerbotten och i Norrbotten intervjuades. Det insamlade materialet analyserades utifrån en kvalitativ innehållsanalys och resulterade i tre kategorier: ?Strukturens betydelse för en effektiv rehabiliteringsprocess?, ?Samarbete ger rehabiliteringen ett mervärde? och ?Arbetsterapeutens roll med aktivitet i fokus?. Resultatet visade på behovet av ett strukturerat arbetssätt i teamet där en gemensam ledare är betydelsefull för att driva rehabiliteringsprocessen.

Reumatoid artrit (RA) är den vanligaste inflammatoriska sjukdomen i Sverige. Artros är en icke inflammatorisk sjukdom. En del av behandlingen för reumatiker idag består av patientundervisning i grupp. Genom patientundervisning ökar patientens kunskaper och bättre förutsättning till egenvård ges. Syftet med studien var att beskriva kursdeltagares erfarenheter av patientundervisning för reumatiker fem år efter avslutad kurs.

In this master thesis, which is made in a qualitative manner, we have as purpose to investigate the nurses' estimation of the hospital welfare officer. We find it interesting to take a closer look at their opinion, because of our earlier, bachelor thesis, based on the same subject, only then in the welfare officer´s perspective on themselves. We have interviewed ten nurses and our questions at issue were the following four: Where in the hospital´s hierarchy do the nurses place the welfare officer? In what way do the nurses look at themselves and on the fact that they are leagally authorized? How do the nurses define the welfare officer´s occupational sphere and his part of the medical care? Which opinion do the nurses have on the co-operation with the hospital welfare officer? The primary information, together with two maintheories and a collection of litterature on the subject have helped us to answer the four questions of issue. We have found that the results we see, in some ways are compareable to our first investigation.

Staphylococcus aureus is the most clinically important Staphylococcus species and is associated with high mortality in patients with positive blood cultures. S. aureus bacteria may cause a variety of disease manifestations ranging from minor skin infections to life-threatening conditions such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS) and sepsis. This microorganism belonging to the gram positive cocci may also be part of the normal flora. In Sweden, penicillinase-stable penicillins are the primary alternatives to treat S.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

Syftet var att beskriva erfarenheter från föräldrar med långvarig smärta av hur deras delaktighet i aktiviteter med barnen påverkas. En kvalitativ metod valdes och totalt åtta kvinnor mellan 37-52 år intervjuades. Den kvalitativa innehållsanalysen resulterade i fyra kategorier: ?Barnen får ta ansvar för aktiviteter?,? Deltar utifrån egna förutsättningar?, ?Behov av stöd från andra personer? och ?Behov av att planera aktiviteter?. Resultatet visar att barnen får ta ett stort ansvar för egna aktiviteter och för hushållsaktiviteter.

Causes of thrombocytopenia in dogs ? a retrospective study of 123 cases The purpose of this retrospective case study was to determine which diseases are associated with thrombocytopenia in Swedish dogs. Records of 123 dogs with thrombocytopenia were evaluated. The most common cause was neoplasia-associated thrombocytopenia (32%). The largest proportion within this group was unspecified neoplasia.

This bachelor thesis aimed to explore, in a qualitative manner, the relationship and the interaction between the hospital welfare officer and the rest of the nursing staff. We chose this subject because we wanted to explain the phenomena of being a medical outsider in the nursing team. Our questions at issue were the following three: How does the hospital welfare officer define his occupational sphere and how do the rest of the nursing staff define it, according to the welfare officer himself? Is the welfare officer's relation to his own professional role and to the rest of the nursing staff affected by where his office is placed - secluded from or within the clinic? How does the welfare officer himself value his profession in relation to the rest of the nursing crew? To answer these questions we interviewed eight welfare officers, placed in two different hospitals. We used three different theories to explain the primary information.

This student report is about canine atopic dermatitis It includes a description of the immunologic mechanisms and how the reaction affects the body. The symptoms are various, most common is pruritus, erythema and alopecia and directly associated with the immunologic reaction. The diagnostic process includes symptoms, physical findings, differential diagnosis, intradermal test and serological test. The options of treatment are several and vary for each patient. The report includes hyposensitization, medical treatment such as corticosteroids, antihistamin and cyclosporine, topical treatment, fatty acid supplements and environmental treatment. The prognosis is individual for each patient due to their different response to the treatment. It may take a while to find the right combination of treatments to achieve satisfactory control of the disease..