Tumour development occurs to a large extent because of dysregulation of the cell cycle. Of particular importance are defects occurring in the G1 phase. The reason why G1 is critical is because of the influence of several signals (external signals as well as cyclins and cdks) on this stage. The G1 phase can be divided into two parts, G1pm and G1ps. Each part has its ?own? restriction point which needs to be passed in order to progress to S phase.

AbstractRunning an individual bookstore is not an easy task. And then to do it in a profitable way is even harder.In this study you will read about what matters to the profitability in a bookstore. There are several aspects of this but it may be of interest to know what is affecting most of a bookstore's profitability.These three theories were researched by examination of previous research. The theories were then compared to the empirical research of an individual bookstore. Developing the empirical research qualitative and quantitative data collection methods was used.

This study compares the sample variance of the mean in a simple random sample (SRS) and a systematic sample from a surface. The study also compares the prediction error variance in a SRS and systematic sample from a random field. Recommendations are presented on which method to use in the clearance and exemption process in the nuclear industry. The results indicate that quadratic systematic sampling outperformed SRS in most instances and proved to be especially efficient in the presence of a long-ranged covariance function and high sampling intensity (i.e. short distances between observations).

Sahlgrenska Academy at University of GothenburgDepartment of Internal Medicine and Clinical NutritionAbstractTitle: The effect of a high versus low carbohydrate intake on endurance performanceAuthor: Emma Andersson and Josefine DahlqvistSupervisor: Fredrik BertzExaminer: Frode SlindeProgramme: Dietician study programme, 180/240 ECTSType of paper: Examination paper, 15 hpDate: May 22, 2013BackgroundCarbohydrates play a significant role in the human metabolism, especially during training. Manystudies have investigated the effects on different carbohydrate intakes on training performance. Thescientific researchers have met a consensus in the fact that a higher intake of carbohydratescompared to a lower carbohydrate intake improves athletic performance. Lately, the increasedinterest in low carbohydrate diets has despite these recommendations gained followers globally.ObjectiveTo determine if a higher carbohydrate intake results in a better endurance performance, comparedto a lower carbohydrate intake, for adult males and females, measured as time to exhaustion, totaldistance covered and power output/cadence. To be able to give nutrition recommendations toendurance athletes based on the current scientific evidence and identify if there is need for furtherresearch in this area.Search strategyThe databases used for the literature search were PubMed and Scopus.

After been told that an ordinary winter service for our combine should cost more than 20000 SEK, not included spare parts, I decided to write this paper about today?s requirement of the workshop on a farm. I think that the lack of proper premises is the reason way not more of the ordinary machinery maintenance or upkeep is performed on the farm. When I did my literature survey I found that the Swedish environmental code, set by the Swedish law regulate how drain or sewer should be built. The environmental code however leaves a lot for your own interpretation. It might not be so bad but it must be very hard for the local environmental office to interpretation the regulations, since they are the ones that gives permission for the sewer in your workshop.

After been told that an ordinary winter service for our combine should cost more than 20000 SEK, not included spare parts, I decided to write this paper about today?s requirement of the workshop on a farm. I think that the lack of proper premises is the reason way not more of the ordinary machinery maintenance or upkeep is performed on the farm. When I did my literature survey I found that the Swedish environmental code, set by the Swedish law regulate how drain or sewer should be built. The environmental code however leaves a lot for your own interpretation. It might not be so bad but it must be very hard for the local environmental office to interpretation the regulations, since they are the ones that gives permission for the sewer in your workshop.

The overall aim is to examine how the European Union Water Framework Directive has affected the local water management in the catchment Märstaån situated in the eastern part of the lake Mälaren river basin, Sweden. The first part of the study gives an historical overview of the area with focus on how the old agricultural landscape was handling the nutrient load from farming activities by means of different kinds of wetlands. By using the concept of the procedural landscape, introduced by Torsten Hägerstrand , together with historical maps with dates starting from the 17th century, the pre-modern landscape is analyzed.  The second part is an investigation, based on qualitative data, on how the different actors in the catchment area work together to secure the water quality for the Märstaån river. The analysis shows that the Märstaån catchment river systems are mostly unchanged in the rural areas.  The exception is the mainstream section of the Märstaån river running partly underground today and the Halmsjöbäcken river that is heavily affected by the Arlanda airport situated within the catchment area.

Information about the risks involved shall be distributed to the people living in the area nearby to potentially dangerous installation. Swedish law stipulates strict requirements on what information should be supplied, but the law itself does not give any guidance on presentation. The main purpose of the study is to give recommendations on how to improve the information brochures. Within the study, eight people working with risk information have been interviewed and seven different risk information brochures have been studied. Also, a theoretical analysis and a practical experiment were performed using brochures from two municipalities.

The Volvo Trucks plant in Umeå is a highy complex manufacturing facility where the same production line handles a variety of different models. This require flexible and agile processes with high quality standards. This thesis studies the flow of material through a production line and how Volvo can use their existing manufacturing monitoring system to optimize the flow of materials.The goal with the thesis is to identify eventual problems with the flow of materials and to deliver a few proposals on how the production line can improve its productivity. The theory of LEAN, Just-In-Time and Supply Chain Management serves as the scientific reference to this project. By analyzing the flow of material, performing interviews and observing the processes a few problems are identified.

To be allowed to sell Z-suspended vehicles with dipped beam Xenon or LED lighting, Scania have to develop automatic headlight level control. This master?s thesis aims to be the foundation to that development.The thesis consists of several parts; a market analysis of how competitors to Scania and the general vehicle industry solve this problem; several available principles for detecting the amount of control needed; the construction of a test station for sensors, a control unit and components connected controlled by the control unit; a further theoretical and practical development of one principle ? one rotational sensor connected between the chassis and the back drive axis; a state flow model programmed in Simulink that produces the control signal for the headlight leveling from the sensor input.Lastly the thesis gives some recommendations to the further development and implementation of automatic headlight level control on Scania vehicles..

This report tries to discuss the concept of social sustainability; what it means and how residential development can be made more socially sustainable. This is done by interviewing several and various representatives in JM AB, the municipality of Uppsala and residents of Åriket to explore how JM AB as a housing developer and the municipality are working with issues regarding social sustainability and what the residents in one of the new housing projects themselves think of these issues. The result of these interviews will be compared and analyzed with the prospect of finding common variables and hopefully ways of improvement.This will result in our own recommendations of areas of improvement either by broad initiatives or specific actions to increase the social sustainability. Areas such as meeting places, sustainable functions and joint efforts between different parties. During the work on the report we come in contact with several other areas of interest that we are not able to process ourselves and therefore recommend them for future studies..

In this work we have compiled results from various studies concerning medical conditions that may possibly be avoided by castration and the effects that may occur after castration of the healthy bitch. The work is a literature review but it also includes a summary on the age recommendations for castration of the healthy bitch, castration before or after the first heat and the castration method most commonly used of ovariohysterectomy and ovariectomy. The summary is based on a questionnaire answered by personnel from 20 veterinary clinics and animal hospitals evenly distributed throughout Sweden.The summary showed that ovariohysterectomy was the most common method of castration and the recommendation in age ranged from 6-12 months. Regarding castration before or after the first heat 75% of the veterinary clinics and animal hospitals answered that they recommended castration after the first heat. Literature study shows that there are both advantages and disadvantages of castration of the healthy bitch and that it therefore is important that each bitch get a personal and individual evaluation before a decision is taken concerning a castration..

BackgroundMalnutrition in hospitalized patients has a high prevalence. This led to an action plan against malnutrition that was conducted in 2012 at Enköpings hospital. This paper investigated the nursing staff perceptions of this project on nutrition and nutrient intake in two different departments, and whether these perceptions differ between departments. MethodAn inductive approach with semi-structured interview was used in interviews with eight persons from the staff of the two departments of the hospital in Enköping involved in the project. Interviews were recorded, transcribed and analyzed by content analysis. ResultsIn the interview material four categories were identified as well as six different subcategories. The different categories were: "Attitude", "Knowledge", "Procedures" and "Workload".

To business owners and consumers electronic commerce means new conditions and possibilities. Often and specially at the Internet information between consumers and sellers is asymmetrically distributed. Among the consumers there is a shortage of confidence in electronic commerce. In order of a positive development of electronic commerce it´s important to find a solution to the shortage of confidence. Confidence may be created by legislation or by self- regulation.

The interest for organic food has grown a lot over the last 15 years. Even so, only 3.5 % ofthe share of wallet in Sweden goes to organic food. The purpose of this study is to examine and describe how retailers can get consumers to buy more organic fruits and vegetables. The study was carried out by visiting six Coop Konsum-stores, of which three performed poorly and three performed well in organic sales. We conducted interviews with the department managers, customer surveys and in-store observations.