Leber´s hereditary optic Neuropathy (LHON), a disease affecting vision, is caused by several point mutations in mitochondrial DNA. Mutations leading to a defect NADH ubiquinone oxidoreductase protein will affect the respiratory chain and cause a disturbed ATP production. It is still unknown why this defect leads to the degeneration of retinal ganglion cells and cells in the opticus nerve as well as demyelination of axons in these areas. Analysis of mitochondrial DNA is an important tool in the diagnosis of the disease. At the present time analysis is based on cleavage by restriction enzymes, which only detects two of the most frequent mutations: m.3460G>A and m.11778G>A.

Auditory Neuropathy Spectrum Disorder (ANSD) is a collective term for a specific form of hearing loss within a heterogeneous population of patients with mutual audiological test-profile. Cochlear implantation in children with ANSD has been found to result in good outcomes. Previous research, however, has shown the existence of a subgroup of children with ANSD who do not benefit from cochlear implantation but instead are in need of alternative methods of communication. The aim of this literature review was to examine the possibilities to predict outcomes of cochlear implantation in children with ANSD by pre-, intra- or postoperative examinations/measurements and thereby evaluate in which cases cochlear implantation is an appropriate intervention within this group of patients. The material consisted of 10 scientific papers published between 2007-2014.

This work is a combination of a literature study and a practical pilotstudy. In the literature study essential physiological reasons of why anaesthesia of horses is so risky are explained. Diffrent methods of induction and recovery are brought up, together with significant aspects of positioning the horse on the operating table and perianaesthetic complications such as myopathy, Neuropathy and limb fractures. The pilotstudy had the purpose of examine the bodytemperature of horses undergoing general anaesthesia and to control the perianaesthetic temperature measurements performed in Swedish horseclinics and veterinary hospitals. Our hypothesis was that the bodytemperature of the horses would decrease but not enough to cause a problem. The purpose of this work has been to gather more profound knowledges in the subject of perianaesthetic nursing of horses which is an important part of the assignment of a veterinary nurse..

Background: Nerve mobilisation is a controversial subject which has undergone great development in recent decades. Nerve mobilisation is based on a concept of both examination and treatment of the nervous system. Purpose: To study nerve mobilisation as a treatment in physical therapy with emphasis on evidence regarding the method. Method: A literature review. The search was made through the databases: PubMed/Medline, Academic search, PEDro and CINAHL/webspirs.

Skin temperature is detected through signals in unmyelinated C-fibers and thin myelinated A?-fibers in the peripheral and central nervous system. Disorders in thin nerve fibres are important and not rare but difficult to diagnose by the most common neurophysiological methods. In this pilot study different methods for quantitative sensory testing, QST, were compared to give some ideas about which method could be the most efficient to use in order to point out injuries of the sensory system in clinical practice. The comparison was made between Békésy (separate warmand cold thresholds) and Marstock test (combined warm and cold thresholds).

Bakgrund: Fotsår är en vanlig komplikation vid diabetes typ 2. För att minska risken för fotsår och amputationer ska sjuksköterskan med hjälp av styrdokument och lagar arbeta tillsammans med personen för en bättre vård. Syfte: Att beskriva sjuksköterskeledda fotvårdsinterventioner och dess effekter för personer med diabetes typ 2. Metod: Studien är gjord som en litteraturstudie med elva vetenskapliga originalartiklar. Resultat: Resultatet utgår ifrån tre huvudkategorier.