Today the individual ventilated cage system (IVC-system) is the most commonly used system when housing rodents. IVC systems are designed to control both supply and exhausted air at cage level, as well as temperature and relative humidity in the cages. This creates an optimal environment for the mouse and at the same time a protection against the risk of cross-infection between cages and the outside environment. The aim of this study was to evaluate the health and welfare for two different strains of laboratory mice (NMRI nude mice and C57BL/6NCrl mice) in three different kinds of IVC-systems; Arrowmight, Allentown and Tecniplast. 108 mouse pups from each strain (in total 216 mice) were selected after weaning at an age of three weeks and tested during 5 weeks.

Today the individual ventilated cage system (IVC-system) is a commonly used housing system for mice in research facilities. IVC systems have HEPA- filters and are designed to control both supply and exhausted air at cage level, as well as temperature and relative humidity in the cages. This creates an optimal environment for the mouse and at the same time a protection against the risk of cross-infection between cages and the outside environment. The aim of this study was to evaluate the health and welfare of breeding females and pups of two different strains of laboratory mice (NMRI nude mice and C57BL/6N) in three different kinds of IVC-systems; Arrowmight, Allentown and Tecniplast. The NMRI nude (Nu) females gave birth to 18 litters in Allentown, 16 litters in Arrowmight and 15 litters in Tecniplast.

Denna rapport behandlar ämnet magnetisk resonanstomografi (MR), och kan sägas vara en orientering i ämnet, då många av de inom MR förekommande begreppen behandlas och systemets grundfunktioner tas upp. Det finns mycket litteratur i ämnet och för den intresserade finns alla möjligheter att fördjupa sig, referenslistan längst bak i detta arbete kan tjäna som boktips och guide till att komma igång med vidare studier. Arbetet tar upp den fysik som ligger till grund för magnetisk resonanstomografi och begrepp som protonspinn, nettomagnetisering och relaxationstider gås igenom. Dessutom görs en genomgång av hårdvaran i MR systemet och de olika varianter av system som finns, det vill säga permanenta-, resistiva- och supraledande magneter. Detta arbete fäster störst vikt vid de supraledande magnetsystemen eftersom de är de klart dominerande kliniskt.

The mouse (Mus musculus) is the most commonly used mammal in biomedical research and can easily be restrained by both hand and by a device. Restraining animals causes stress that not only decreases the animal?s wellbeing, but may also influence the research results. The first aim of this study was to train mice to voluntarily stand still using positive reinforcement training. Another benefit of teaching a mouse to stand still is that you can avoid anaesthesia for some procedures.