In vitro-test för upptäckt och behandling av tumör eller mikrometastaser har de senaste 30 åren gjort stora framsteg tack vare immunokemi och nya framgångsrika cellodlings- tekniker som bättre reproducerar celltillväxt i tre dimensioner (3D) och det omgivande stromat (multicellulär tumörsfäroidodling). TS1-218 scFv (single chain variable fragment) är en monoklonal antikropp som har affinitet till ett protein tillhörande cytoskelettet (cytokeratin). Av TS1-218 har skapats olika varianter (en dimer TS1-2182 och en mutant HE1-Q) med syftet att öka affinitet och retentionstid på platsen för dess verkan. I det här projektet försökte vi att testa och jämföra egenskaper hos alla 3 joderade antikropparna genom att inkubera odlade Hela Hep 2 tumörcellssfäroider med dessa antikroppar. Alla tre antikroppsvarianter visade god förmåga att penetrera sfäroider och att binda deras epitop i cytokeratin 8.

This study has its background in the debate about religion and the existence of God, which has been an ongoing issue throughout the Western cultural tradition. Today´s information society has been an impact on the increasing interest for this subject. The essay?s main task is to accomplish a rhetorical analysis of two books, Illusionen om Gud (2008) by atheist Richard Dawkins and Guds dödgrävare (2010) by Christian John Lennox, in order to investigate the authors? use of rhetorical strategies to influence their audience. The texts are studied using a qualitative approach with the theoretical basis of some well-defined rhetorical variables: ethical, logical and pathetic means of persuasion, propaganda, and the important factor that a message always is presented in a certain context in which the recipients both have their own values and subjects to general truths and common frames of reference.

The relationship between dividend policy and investment is a controversial area and the relationship between these two may differ depending on the company's priorities. The study examines this more closely by studying dividend policy's impact on investment and how it differs depending on the company?s market capitalization. The study is based on companies listed on the OMX Stockholm within the segments Large Cap and Small Cap, during the period between 2003-2012. Secondary data was obtained from each company's annual reports where relevant data was used to operationalized into measurable variables.

The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

This paper aims to describe the variation and develop a method to control the production for the product Metropol Kaktus from the snuff developer Fiedler & Lundgren. We are going to use the requirements from the product specifications as limits of the expected quality when we present methods to control the process. One method attempts to control during the process and the other attempts to maximize the number of products with strived quality before the process starts. Metropol Kaktus is a product produced with high quality, the mean weight is 20,023 gram and this is very close to the weight, 20 gram, which is reported in the product specifications. The variation in weight variable is less than what is reported in the specifications and the minimum weight is over the limit set by Livsmedelsverket.

The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

The purpose is to describe and analyze Handelsbanken?s proftit share system Oktogonen and to investigate how it affects the motivation among the employees and management.The method qualitative case-study has been used. Both primary and secondary sources act as a foundation for the thesis. The primary sources are based on eight qualitative interviews. The empirical material is completed with appropriate theories.

In this study we examine four Swedish newspapers? visual coverage of the Tunisian and Egyptian uprisings in 2010 and 2011 ? commonly known as the ?Arab Spring Revolution?, the ?Jasmine revolution? and in Sweden also the ?Women?s revolution? ? focusing on three main perspectives: news values and framing, postcolonialism, and gender.By means of a comprehensive content analysis and an in-depth semiotic analysis, the purpose of this study is to investigate how Swedish written media frames the revolution and its initiators and partakers through news photographs, headlines, lead paragraphs and photograph bylines, and to determine whether or not it reproduces earlier trends of media coverage and framing of non-Westerners and non-Western societies.The purpose of the extensive content analysis is to attain data for empirical research of the visual portrayal of the uprisings? first twelve weeks in Sweden?s four largest newspapers Dagens Nyheter, Svenska Dagbladet, Aftonbladet and Expressen. The analysis reveals that episodic framing is regularly used in all four newspapers, and that media demonizes Tunisians and Egyptians by constructing them as a brutal, uncivilized and threatening group which almost exclusively consists of men, and whose members are neither quoted nor named. It also shows that women are symbolically annihilated by media and that the very few women who do occur are gender stereotyped in accordance with established media conventions and postcolonial tradition, with the interesting exception of women being quoted to a larger extent than men. The analysis furthermore confirms the low occurrence of female journalists in Swedish foreign reporting, as well as demonstrates that the gender of the journalists does not influence what types of stories are written or how they are framed.The variable frequencies obtained from the content analysis provide indicators which are subsequently explored in the semiotic analysis of four news photographs.

The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

The purpose of the present study was to examine effects of driver, vehicle, and environment characteristics on Collision Warning System (CWS) design. One hypothesis was made that the capability of collision avoidance would not be same among a driver, vehicle, and environment group with different characteristics. Accident analysis and quantitative analysis was used to examine this hypothesis in terms of ?risk? and ?safety margin? respectively. Rear-end collision had a stronger focus in the present study.

The work examines geographical variations of bicycle use in Trondheim municipality with the aim to create an understanding of what influences the use of bicycles and explain the geographical travel pattern for cycling. The work focuses on the how physical structures generates different transports effects. Where bicycle travels in Trondheim municipality are undertaken is described by using network analysis in ArcGIS, based on aggregated data from the travel habit survey (RVU) in 2009/2010. Trondheim municipality is divided into smaller geographical units (zoner) whose characteristics are described by 19 variables, categorized into 6 groups; Distance, Land use, Topography, Bicycle Facilities, Road characteristics and Demographic factors.By linear regression analysis in SPSS and ArcGIS Spatial Analyst, an explanatory model is elaborated. The variablesdistance to the regional center, workplace density, percentage separate bike paths and hilly terrain explains 78 percent of where cycle journeys are undertaken.

In this bachelor essay an attempt is done, to recreate a probable Bronze Age landscape on Gotland, with GIS as a tool. The landscape on Gotland is situated with many different monuments dated Bronze Age, such as cairns and stone ships. In creating of the maps, two possible shorelines contemporary with the Bronze Age have been calculated and marked on the maps. Furthermore, peat lands have been drawn upon the maps, by using the information from geological maps.A landscape variable have been compared between Bronze Age places and Early Iron Age houses; the soil type. On Bronze Age places gravel is the most common, while moraine marl is the most common on places with Early Iron Age houses.From a selection that were made, all Bronze Age places where within 3 km from the water, either the recreated shoreline or peat land.

The main objective of this study is to divide a number of colorectal cancer cases into subgroups based on their molecular features using cluster analysis. The data used is supplied by a research group at Pathology, the Department of Medical Biosciences, Umeå University, and consists, after some preparation, of 455 observations which is a larger data set than many similar studies. The molecular variables that the clustering is based on are CIMP (CpG Island Methylator Phenotype), MSI (Micro Satellite Instability), BRAF- and KRAS-mutations. These are categorical variables and consequently the clustering method used is PAM (Partitioning Around Medoids) which is particularly useful with data on diverse variable level. The final analysis results in four subgroups that are represented by different combinations of attributes on the aforementioned variables.

The aim of this paper is to examine, by means of a quantitative method, whether using a Swedish athlete endorser in a sports advertisement will increase its effectiveness. We examine which characteristics an athlete endorser needs to be able to make people form a positive attitude towards the athlete endorser and thereby make him or her successful in advertising. We also look into whether an interest in sports can affect the advertisement effectiveness when using a Swedish athlete endorser. The results show that a well-liked Swedish athlete endorser generates highest ad effectiveness and that the most important characteristics that contribute to form a positive attitude towards an athlete endorser are trustworthy, physical attractiveness, success in sports and ?successful in respondent?s mind?.

The purpose with this paper is to examine if tertiary education and democracy have an impact on economic growth. In order to decide how democratic the examined countries are the democracy index constructed by The Economist is used. Besides the two central theories the purpose is also to explain why these variables could affect growth and to examine direct and indirect effects. Indirect effects mean that one variable affects another variable which thereafter has an impact on economic growth.34 OECD countries are compared in order to investigate whether education and democracy are strongly correlated with BNP per capita. Therefore a statistical design is used as method.The empirical results suggest that there is significant correlation between democracy and economic growth.