The process of drug discovery is very slow and expensive. There is a need for reliable in silico methods; however the performance of these methods differs.This work presents a targeted study on how the drug discovery methods used in OpenEye?s tools ROCS, EON and FRED perform on targets with small ligands. It was examined if 12 compounds (markers) somewhat similar to AMP could be detected by ROCS in a random data set comprised of 1000 compounds. It was also examined if EON could find any electrostatic similarities between the queries and the markers.

The study investigated pensioners? forming of identity during the ageing process and the correlation between norms and identity. Previous research has shown that there are norms and notions about elderly and what growing old well implies. There is missing research on the level of the individual with norms, ageing and the process of identity formation. There is a large population of pensioners in Sweden and the authors behind this study wish that the results of it will help study counsellors to approach pensioners? in a norm critic way.

Today, some kind of laboratory results is required for around 70% of the diagnostics and follow-ups for diseases. In many of the cases the time from sampling to a result is very critical. Therefore the discussion of how to improve this situation has begun. For many analyses serum has been the routine choice for a long time but now it is disputed. After blood collection in a serum tube it is essential to wait 30-60 minutes before centrifugation and analysis of the sample, a long time for someone in an acute state.

The interest in horses and equestrian sport is constantly increasing, and so is the will in both riders and trainers to learn more about the effect the rider and its equipment have on the horse. The last twenty years, more and more studies have been performed were the horse and its kinematics have been in focus. The access to more advanced technology has made it possible to study areas, which earlier have been hard to reach. The knowledge about kinematics in the horse, and how riders and their equipment interact with the horse?s movement, is also of great interest to veterinarians in equine practice.

Research establishes, that clothes constantly communicate something about its wearer. You send out different messages depending on what sort of clothes you are wearing. For example, a suit can project social status and power, while, a pair of jeans usually conveys a more casual impression. Either way, research state that clothes are symbolic expressions.This essay focuses on the theme clothes and pupils within the school world. Do pupils today experience clothes as symbolic values? By using qualitative interviews, I have examined how four senior high school pupils talk about clothes and its potential symbolic value in school.

Lame dogs are a common group of patients for the practicing veterinarian. In the literature it is described how a clinical examination can be performed, based on general clinical-, orthopedic- and neurological examination, and visual evaluation of the dog when standing and during motion. For research, objective gait analysis systems are also used to study clinically healthy and lame dogs during motion. The aim of this degree project was to compare objective kinematic gait analysis with a visual evaluation of dogs with different types of lameness. The project was a pilot study to show if objective gait analysis could be used as a support for the visual examination. Ten lame dogs of different breeds and with different diagnoses were included in the study. They were all patients at the University Animal hospital, Uppsala.

Background. Immunohistochemistry is a useful method in the differential diagnosis between pleural mesotheliomas and metastatic adenocarcinomas in the pleura. Cytokeratin 20 and 7 have been used successfully as markers in studies determining primary location of adenocarcinomas from metastases. The current study is a complementary research of archived paraffininbedded material of cases with cancer origin. This study contributes a bigger statistical material that may facilitate the search for unknown primary site of adenocarcinoma by identification of metastatic cells in the pleura.Methods.

Multiple Congenital Ocular Anomalities (MCOA) is a genetic disease that affects primarily Silver coloured horses of breeds such as the Rocky and Kentucky mountain horses. In these breeds the Silver dapple colour is very popular leading to an increase of affected horses. The major feature of the disease is ocular cysts of variable size. Large cysts also lead to a variety of secondary syndromes, for example retinal detachment. In previous studies the locus for MCOA has been mapped to an interval of 420 kb on equine chromosome six.

Acupuncture has been used for thousands of years in China. Written documents concerning veterinary acupuncture has been found dated around 650 B.C. Acupuncture has gained greater acceptance in the western world the last decades and many countries have established their own veterinary acupuncture organizations. Many studies report good results after acupuncture treatment and back pain in horses is considered a good indication for acupuncture treatment. In studies published, the results are subjectively evaluated. To get a qualitative, scientific evaluation of acupuncture treatment, objective measurements, control groups and statistical analysis are needed. This pilot study presents a case where acupuncture has been used for treatment in a horse that was diagnosed with back pain.

Dressage schooling is not a subject that rests on science, it is a matter of dependable experience. So far there hasn?t been so much research about it, but more and more is done. Especially the interaction between rider and horse is a nearly uninvestigated field. Riding skills is much about having the right position, and having the horses head and neck in different positions, but there are no research done that support or deny that this old ?knowledge? is for the best for the horse. This study was performed to evaluate if the head and neck position of the horse, and the velocity, has any influence on the position of the rider.

To explore how children use dialect, and whether the dialectal language develops during growth might be of interest from a speech language pathologist?s point of view as the dialect could influence the child?s speech. Previous research is often based on older material and/or examines the speech of adults.  In the present study, everyday language in groups of south- eastern Swedish speaking children was investigated. The aim of the present study was to examine to what extent typically developed children of the ages of  5, 8 and 11 years use dialectal language. A further purpose was to discover which dialectal characteristics that were present in the different age groups, and how they differed.

Spitz nevus was first described by Sophie Spitz in 1948 as juvenile melanoma. The lesion is a benign melanocytic tumor, which consists of epiteloid- and spindelshaped cells. Histological is spitz nevus difficult to distinguish from malign melanomas and spitzoid melanomas. Loss of symmetry, loss of maturation in the deep component, nuclear polymorphism and hyper chromatic nucleus are features which can be found in melanomas. Some of these features are often seen in spitz nevus.

Synen på vad som utgör akademisk skrivkompetens varierar över tid och i olika kulturer. Förmågan att strukturera texter på ett logiskt och begripligt sätt kan dock ses som en universell vetenskaplig kompetens oavsett skrivmiljö, liksom förmågan att värdera kunskap och ta ställning i relation till olika källor. Denna studies syfte är att undersöka och kategorisera förekomsten av markörer för textuell organisation och ställnings­tagande i en grupp gymnasieelevers utredande texter samt att undersöka sambandet mellan bruket av dessa markörer och texternas betyg. Studiens korpus består av 18 utredande elevtexter, jämnt fördelade mellan betygen A, C och E. Texterna har analyserats genom kvalitativ närläsning med en analysmodell avsedd att fånga uttryck för textuell organisation och ställningstagande.

Genomic selection (GS) is used for selection of breeding animals of dairy cattle. GS is though not as extensively used within the beef industry. One reason for that is the low accuracy (rTI) of the breeding value that is of great importance for the final genetic gain. Causes to the low accuracy are high effective population size, a small reference population and a genetically differentiated population. There is however a market for genomic selection with High Density (HD) tests for beef cattle.

This study investigates augmented reality using third person perspective and what precision can be achieved by using this method. There have been prior studies in regards to precision using augmented reality, however studies using third person perspective is scarce. This study presents a solution using a static camera capturing the user as well as the plane to augment from behind. This augmented image is then transferred to a handheld device that is held by the user. Using this method the user will be free to manipulate and work with the plane without removing the device that captures the scene, a common problem when using visual reference markers in augmented reality.