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3204 Uppsatser om Low density lipoprotein receptor related protein 1 (LRP-1) - Sida 55 av 214

Epigenetic regulation of the Igf2/H19 gene cluster

Igf2 (insulin-lik tillväxtfaktor 2) och H19 är präglade gener hos däggdjur. Präglade gener uttrycks ojämnt; den allel som ärvts från den ena föräldern uttrycks mer än den från den andra. Igf2-genen kodar för en viktig embryonal tillväxtfaktor och uttrycks till protein bara från den paternella allelen. H19 transkriberas bara från den maternella allelen, men translateras inte till protein. Igf2 spelar en viktig roll under dräktigheten, då den bidrar till tillväxten av både placenta och foster och reglerar såväl näringstillgång och tillväxthastighet för embryot. Enligt en teori kallad ?the genetic conflict theory? (~konflikten mellan genomen) så ligger det i honans intresse att fördela resurserna jämnt mellan alla syskon.

Pertuzumab som tillägg till behandling med trastuzumab och docetaxel vid metastaserad HER2-positiv bröstcancer

I Sverige drabbas närmare 8000 kvinnor av bröstcancer varje år. Bröstcancer är vanligast hos kvinnor över 40 år och utgör 30 % av alla cancersjukdomar hos kvinnor. Cirka 25 % av alla bröstcancerformer är HER2 (human epidermal growth factor receptor) -positiva. HER2-positiv bröstcancer resulterar i en aggressiv fenotyp och en väldigt dålig prognos.  Varje år får cirka 1300 ? 1400 bröstcancerpatienter en spridning av sin sjukdom.

Läkning av trycksår - Effekten av olika behandlingsmetoder, en systematisk litteraturstudie

Syftet med denna litteraturstudie var att undersöka om nutritionstillskott, tryckavlastning och typ av förband har någon påvisad effekt på läkningen av trycksår. Litteraturstudien grundar sig på Goodmans systematiska tillvägagångssätt. Litteratursökningen gjordes i CINAHL, PubMed och The Cochrane Library samt att artiklar som inte var tillgängliga i fulltext via någon av databaserna söktes via Samsök. Granskning och kvalitetsbedömning av artiklarna gjordes individuellt utav författarna oberoende av varandra utefter ett modifierat granskningsprotokoll. Elva artiklar av varierande kvalitet inkluderades i litteraturstudien.

Vad kännetecknar en bra respektive mindre bra lärare? : En studie om gymnasieelevers syn på ledarskapskompetens i klassrummet.

The purpose of this project is to examine students' pespectives on quality in teaching. The characteristics that are described to denote a 'good' and 'less good' teachers are linked to ideas about types of corresponding leadership styles in the classroom. The report is based on surveys of students in Upplands-Bro high school outside Stockholm. In order to get better insight and further knowledge of the subject, the student accounts have been related to current discussions in the literature about good leadership and teaching quality.Following the methodology of grounded theory a pilot study was constructed to design the research instruments. In the pilot study I collected students' perceptions on quality-related categories in teaching and leadership which then formed a bases for a survey which was distributed to a larger student sample. The survey includes questions that relate to the middle order, which is based on three criteria that make up the characteristics of a 'good'/ 'less good' teacher and the leadership style that suits students descriptions of good teacher characteristics.The results of the study show that a good teacher should have subject knowledge, be good at writing and illustrating the curriculum on the whiteboard and explain and clarify their instruction through good communication.

Rörelse och lärande : En studie om lärarnas uppfattningar kring fysisk aktivitet och lärande

Denna uppsatssyfte var att ta reda på vilken kännedom som finns om de svenskanäringsrekommendationerna hos människor på ett antal svenska arbetsplatser. Syftet har även inne-fattat att ta reda på huruvida man använder sig av denna kännedom eller inte.Metod: Enkvantitativ ansats i en tvärsnittsstudie har använts i denna undersökning och hundratio enkäter har blivit besvarade. Dessa enkäter har analyserats både kvantitativt och kvalitativt.Resultatetvisade att majoriteten av respondenterna inte kände till de svenska näringsrekom-mendationerna. Majoriteten var också omedvetna om hur den procentuella energifördelningen såg ut. Jämförbart med tidigare studier så underskattade männen rekommendationerna för grönsaker medan kvinnorna hade mer kännedom om rekommendationerna som helhet.

Effects of two different light programs on milk yield, prolactin, IGF-1 and sleep in dairy cows

The aim of this study was to investigate the relationship between sleep, photoperiod, milk yield and hormones connected to milk formation. Variations of prolactin (PRL) and Insulin-Like growth factor-1 (IGF-1) in plasma were measured during two different light programs. The light programs consisted of either 24 hours of light (L24:D0) or four hours of light and 20 hours of darkness (L4:D20). Five cows of the Swedish Red breed were used in a cross-over experiment and each light program consisted of five days. Milk yield was measured at every milking and milk samples were analyzed with regard to fat, lactose and protein.

Kvinnors erfarenher av coping och stöd under pågående bröstcancerbehandling : En litteraturstudie

I Sverige drabbas närmare 8000 kvinnor av bröstcancer varje år. Bröstcancer är vanligast hos kvinnor över 40 år och utgör 30 % av alla cancersjukdomar hos kvinnor. Cirka 25 % av alla bröstcancerformer är HER2 (human epidermal growth factor receptor) -positiva. HER2-positiv bröstcancer resulterar i en aggressiv fenotyp och en väldigt dålig prognos.  Varje år får cirka 1300 ? 1400 bröstcancerpatienter en spridning av sin sjukdom.

The distribution of Moose (Alces alces) during winter in southern Sweden : a response to food sources?

The traditional Swedish way of dealing with browsing damages made by moose, is to reduce the moose population. However, a growing way of dealing with damages made by several ungulate species, including wild boars in particular is to redistribute them with supplementary food sources. Attracting them to settle in habitats less vulnerable to damages made during foraging. This study we tracked collared moose in southern Sweden from January throughout April in the year of 2009. From the tracking data their ?favourite? positions was selected and visited in order to study the features that attracts moose during winter.

Diabetes : En studie om informationsbehov och informationssökning kring sjukdomen

The aim of this study has been to examine how people with the chronic disease diabetes are seek-ing information about their disease. The study also look at the sources, which are mainly used, and the information behavior of the participants in this study. Especially in diabetes health care the idea of empowerment is central, which means that the patients need a lot of information to get know-ledge and become empowered. The study also examine the public library as a resource of health information, and for that purpose an examination of the OPAC catalog in two public libraries has been done, using the word ?diabetes? to illustrate the literature and other medias related to di-abetes.

Managementkonsultens roll i projekt : En studie av utvärderingsprocessen

A consultant is an external expert that exists within all types of organizations. The consulting service can be divided into individual practitioners and large companies whose sole task is to hire out consultants to clients. The need for consultants has grown due to the restructuring of Swedish businesses during the past decades. They have put parts of their business on contract. This has led to a market with other player that have been able to focus on these parts.

Sektorsskillnader i aktierelaterade ersättningar - En kvalitativ studie av incitamentsprogram inom OMX Large Cap

Background and problem: There is a continuous debate regarding incentive programs in public companies. Since the global financial crisis and the subsequent recession in 2008, the criticism has reached even higher levels. Various regulatory authorities as well as influential external actors require stronger regulations and limitation of the monetary compensation in publicly held companies. Share-based payments are based on the development of the market value of the company. This means there is an existing relation between the owners? and the managers? interests.

Övertänjd urinblåsa- redan före operation? En observationsstudie

Introduction: Urinary retention is a common postoperative complication associated with bladder distension. Permanent damage to the bladder affects the patient?s quality of life and may lead to a lifelong inability to empty the bladder and needs of self-catheterization with the risk of urinary tract infection. Bladder distension was classified as the fourth largest health care related injury in Sweden in 2013. Bladder distension may occur before the operation starts and is more common among orthopedic patients.

A Comparison of Two Immunoturbidimetric Assay Methods for Serum Amyloid A in Cats.

The analysis of acute phase protein serum amyloid A (SAA) has recently been brought into clinical use in veterinary medicine. Some of the difficulties with incorporating the SAA method in clinical practice have been the expensive and rather large equipment required for the method. Due to these difficulties only larger clinics can afford to use the SAA analysis.The company Equinostic has recently developed a smaller instrument that costs one-tenth of a larger instrument. The instrument is named EVA1 and has so far only been used to analyze SAA in horses.The aim of this study was to investigate if the EVA1 instrument could be used to analyze SAA in cats. This study included 24 serum samples from cat, which were first analyzed twice on the EVA1 instrument and then sent to the Strömsholm Referral Animal Hospital in Sweden where they reanalyzed the samples using a validated reference method.

A risk analysis of moose close to roads

For many decades the increase in traffic volume, expansion of highways and infrastructure has lead to an increase of wildlife vehicle collisions which are unfortunately very common in many countries today. They cause great deal of material damage and even kill humans or wildlife. Measures in the form of warning signs, under- and overpasses and fencing have been implemented for a long time with the help of observation by hunters and collisions sites. However this study focuses on the moose?s perspective and the variables that, both spatially and temporally, could have an effect on why and when moose are close to certain types of roads.

Läroboksspråk : En studie av språket i två historieböcker avsedda för grund- respektive gymnasieskolan

This essay investigates and compares the readability in two different schoolbooks: Eko Historia (the primary school grade 4-6) and Epos Historia (the upper secondary school). The questions of the survey are:- Which differences in linguistic and layout can be found between books meant for the primary school and books meant for the upper secondary school?- Are the texts easy to read according to the former research in readability?In order to answer the questions structural dimensions as lexicon, syntax, bounds between sentences and narrative voices have been studied. Also the texts disposition and typography have been examined.The results demonstrate that the book designed for the primary school has a verbal structure with an explicit vocabulary, lots of verbs and short sentences. A clear narrative voice gives an impression of spoken language.

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