Syftet med denna studie var att påvisa vilka känslor som väcktes hos föräldrarna inför sitt barns hjärttransplantation och hur deras upplevelse av informationen från vårdpersonalen uppfattades. För att kunna genomföra undersökningen användes en anonym enkätundersökning med semistrukturerade frågor. Undersökningens deltagarantal var litet på grund av att få barn blivit hjärttransplanterade på hjärtcentrat. Av sexton tillfrågade föräldrar svarade endast åtta på frågeformulären. I resultatet framkom att föräldrar under kontakten med hjärtcentrat hade både positiva och negativa upplevelser.

Clopidogrel is an antiplatelet substance that prevents blood coagulation in the arteries. It is an inactive pro drug that becomes activated after first-pass metabolism by the liver. The active metabolite of clopidogrel is 2-oxoclopidogrel, which is unstable therefore pharmacokinetic data is obtained by measuring the inactive metabolite clopidogrel acid in plasma. Clopidogrel is taken orally in tablet form. The aim of this project was to develop a LC-MS/MS method for quantification of clopidogrel and its metabolite in plasma. The method has been developed by optimizing the sample preparation.

ABSTRACT (english)Introduction: The possibility to transplant an organ is an important part of the health care system, which demands great resources and a well functioning organization with a level of high competence. The work with organ donation is complex and brings forward a great amount of different emotions for the operation room nurse. Aim: The aim with the study is to illustrate the operating room nurses experience when the organ donor is brain dead. Method: Data collection has been performed with semi-structured interviews, which have been interpreted by qualitative manifest analysis. The design of the study is pilot towards a study in full scale.

Background: There are many people waiting for a kidney transplant. To get a kidney from a living donor has many advantages. The gift is about giving and receiving. The decision is characterized by life-philosophy of the donor.Aim: To highlight the experiences of the kidney donation process.Methods: A systematic literature review in which 11 articles were included, seven qualitative and four quantitative. The articles are quality and ethically reviewed, the results are analyzed according Granskär & Höglund and Polit & Beck.Results: The results were gathered under two themes: the decision-process shows the path from idea to decision and implementation-process treats the donation and confirmation of the gift.

When going through a stem cell transplantation a patient is forced to undergo protective isolation to inhibit risk of opportunistic infections related to the low leucocyte count as a result of aggressive pre-transplant chemotherapy treatment. Protective isolation has shown to have an impact on patient experiences during treatment and the aim of this study is to elucidate experiences of protective isolation of patients undergoing hematopoietic stem cell transplantation and to deduce patient perceptions of the role of nurses in protective isolation care. The presented study was performed as a mixed qualitative and quantitative survey at a hematopoietic ward in Sweden. Results were analyzed by Mayring (2000) and by descriptive frequency charts and show that patients in protective isolation experience alienation, necessity, safety and anxiety with regards to their protective situation. Considering the role of nurses patients perceive their role to be attendant, informant and acting as an executioner of medical implementations.

An inflammatory reaction is induced after release of proinflammatory mediators such asinterleukin 1 and 6 and tumour necrosis factor ?. These mediators stimulate the liver tosuppress the syntheses of albumin and endure the syntheses of acute phase protein forinstance C-reactive protein. The aim of this paper was to perform a method validation on animmune turbidimetric assay to quantify C-reactive protein in canine serum at the laboratory atSkara Animals Hospital, Skara, Sweden. The validation involved evaluation of the assaylinearity, precision, stability and recovery.The method was proved to be linear for both TruLab control and Medinor control.

The purpose of my study is that I have examined children age 4 years and 5 years of their perceptions about the body's internal organs, and if they know where they are sitting in the body, and what their perception of organ systems. I have compared their perceptions and thoughts about the internal organs, to see their similarities and differences it is about childrens perceptions and thoughts dependent if they is 4-respektive 5- years old.The results that I got from my examination was that they showed me a big variety by their earlier perception about the organs. Some had knowledge of the name, some had of the function and some of the place of the organ brain, heart, lungs, stomach, liver and intestines. All these knowledge about the organs was a variety on and you could see similarities and differences in the different ages. One example about a different is that it was a four year old child that could the name of the stomach and the stomach function while there was three five years old children that could the brains name, function and place..

The research in the field of biotechnology is rapidly developing all over the world. Modern biotechnology offers unique opportunities, simultaneously as it gives rise to a number of ethical issues. Preimplantation genetic diagnosis (PGD), PGD/HLA (Human Leucocyte Antigen) and germline gene therapy (GLGT) are controversial techniques. PGD gives a possibility to identify a genetic disease prior to the embryo?s implantation in the uterus.

Bakgrund: Antalet utförda hjärttransplantationer i Sverige ökar och uppgår nu till omkring femtio transplantationer per år. Främsta orsaken till en hjärttransplantation är grav hjärtsvikt. Att drabbas av hjärtsvikt som ung är ovanligt och mycket påfrestande. Om hjärttransplantation blir aktuellt sätts patienten upp på väntelista där medianväntetiden är tre månader. Tidigare forskning visar att sjuksköterskan har en viktig roll i patientens upplevelse under denna tid.

This is an empirical cross-sectional study with the aim to examine the patient?s comprehension about their quality of life within two to seven years after their stem-cell transplantation with reference to physical, social, emotional, psychological and functional wellbeing and to investigate if the patient groups have disease specific problems. Differences in quality of life between men and women and also between allogeneic and stem cell transplantation with an unrelated donor (URD) were studied. The measurement Functional Assessment of Cancer Therapy (FACT) and the bone marrow transplant subscale (BMT) is a 49 item, valid and reliable measure that was used. The questionnaire was answered by 43 of 47 patients (91%).There is a significant difference between men and women in physical, social and functional wellbeing.

Det finns många olika typer av bromerade flamskyddsmedel. De är alla stabila i miljön men graden av toxicitet och bioackumulering varierar. Att bromerade flamskyddsmedel är endokrinstörande är känt men min hypotes är att de även är neurotoxiska och att de kan orsaka neurologiska störningar hos människa. Människor exponeras för bromerade flamskyddsmedel via damm och föda. Barn och foster som är känsligare än vuxna kan även exponeras via modersmjölk respektive placenta. Barn har högre serumkoncentrationer av bromerade flamskyddsmedel än vuxna.

Ultrasound is still a relatively new method for the diagnosis of abdominal conditions in cattle. The objective of this study is to evaluate ultrasound as a diagnostic tool for the common diseases affecting high-producing dairy cattle, for example traumatic reticuloperitonitis, right- and left displacement of the abomasum, fatty liver, wound infections and abscesses. This paper is a combined litterature study and a report of the results from ultrasound examinations of bovine patients at the ruminant clinic at the Swedish University of Agricultural Sciences. The study includes two healthy cows from the ruminant clinic, and seven patients with abdominal related diseases. The examinations were made with a 2-6 MHz curvilinear transducer and both the right and left sides of the abdomen were scanned.

Equine cutaneous melanomas arise much more often in horses with a grey coat color than in horses of other colors. Some scientists have in different studies come to the conclusion that the melanomas are neoplasms which can be classified by examining their histological and macroscopic features. The more defined and demarcated a tumor is, the more benign it tends to be. Other scientists believe that the skin lesions are the result of a pigmentation disorder that is linked to the greying of the coat color. According to this theory, the lesions are not malignant although they have the ability to metastasize.

Hepatitis E virus, HEV, is a frequent causative agent behind, especially waterborne, infections in developing countries such as India. However, during the last years the number of non-travel-associated infections in industrialised countries, for example US, Germany and Sweden, has increased. The symptoms vary from mild with nausea to icterus and it can even be lethal. There are four different genotypes of HEV and many studies consider HEV infection to be a zoonosis. Scientists have by using phylogenetic analyses found great genetic similarity between strains isolated from humans, pigs and food, such as pork and liver, especially among viruses belonging to genotype 3.

Perch (Perca fluviatilis) is a very popular fish in Sweden and it is common in Swedish waters. In some areas along the Swedish coast the perch population has decreased. It is therefore important to get a view at the health status of perch. During April, July and August of 2008, a total of 346 perches were caught in the Gump Bay in the Botnian Sea. The fish were mainly caught by net but also by rod.