Clopidogrel is an antiplatelet substance that prevents blood coagulation in the arteries. It is an inactive pro drug that becomes activated after first-pass metabolism by the liver. The active metabolite of clopidogrel is 2-oxoclopidogrel, which is unstable therefore pharmacokinetic data is obtained by measuring the inactive metabolite clopidogrel acid in plasma. Clopidogrel is taken orally in tablet form. The aim of this project was to develop a LC-MS/MS method for quantification of clopidogrel and its metabolite in plasma. The method has been developed by optimizing the sample preparation.

ÖREBRO UNIVERSITYDepartment of Behavioural, Social and Legal SciencesC-essay in Social work, Advanced course2006To give up a criminal life styleA study of motivation and protectional factors of juveniles after a sentence of institutional care or community workEmma Henriksson & Karin TengnäsABSTRACTThe purpose of the study was to investigate the factors that juveniles sentenced to institutional care or community work perceive as important for their decision to give up a criminal life style. The study approach was based on a few specific questions: (1) What aspects of the treatment have contributed to a motivation to abandon the criminal life style? (2) What have motivated the juveniles to make a decision to leave the criminal life style? (3) Are there any specific internal or external protectional factors that have been decisive for the rehabilitation process and, if so, are they linked to intrinsic or extrinsic motivation? The study rests on the theoretical foundation created by earlier research on institutional care, motivation and protectional factors. Interviews were chosen as a method to secure qualitative data and the interview manual was designed on the basis of themes that reflect the questions of the study. Six young people?s perception of their treatment is documented in the study, as well as their opinion on the effectiveness of the treatment.

The species in the genus bumblebees (Bombus) are important pollinators. In the world there are 250 bumblebee species and there are 34 species in Norway. The purpose of this study is 1) to assess changes in the species composition of bumblebees in twenty different places in Norway that have been inventoried first one time between 1939-1960 and the second time in 2012, and 2) to relate species richness and distributions to current landscape composition with the aid of orthophotos. In this study, I have used regression analyzes on the different bumblebee species that were present or absent at the inventory, using the premises of the following variables: low or high altitude, latitude, longitude and seven different types of land use (farmland, building/plots, open land/pasture, forest, wetland and open or snow-covered ground above the tree line) to see if there was any relationship between each species and the different variables. I have not analyzed what the landscape looked like at the first inventories and therefore we cannot say whether it has changed and if that is why species number has decreased. This would be interesting to study further and to see if there is any relationship between landscape changes and bumblebee?s species decline.

It is said that concepts of organizational management can pave the way to success. This is not accurate and it is something that will be shown in the following study. Its most prominent conclusion is that the valuation governance to some extent has an impact on the formal structures, but that it had no further effects on the employee?s way of work. The purpose of this study was to investigate how the valuation governance is applied in Medley AB and the meaning of it.

A good flow of information in organizations is one of the key aspects of how we define a well-functioning organization. The information flow could be internal as well as external between actors within as well as outside of the organization. In a logistics organization this flow of information is equally important as in any other kind of organization. In this paper we have explored information flows in logistics organizations by applying, boundary spanning and the mobile-stationary divide perspective. In boundary spanning the main goal is to erase or relocate some of the boundaries within an organization, in our case to make the flow of information internally as well as externally better.

A good flow of information in organizations is one of the key aspects of how we define a well-functioning organization. The information flow could be internal as well as external between actors within as well as outside of the organization. In a logistics organization this flow of information is equally important as in any other kind of organization. In this paper we have explored information flows in logistics organizations by applying, boundary spanning and the mobile-stationary divide perspective. In boundary spanning the main goal is to erase or relocate some of the boundaries within an organization, in our case to make the flow of information internally as well as externally better.

Våren 2007 offentliggjorde USA planerna på att upprätta ett missilförsvar i Polen och Tjeckien som ett skydd mot missilangrepp från Iran. Från Ryssland blev reaktionen mot planerna kraftfull. Retoriken från Moskva påminde om kalla krigets dagar. Vilka är de bakomliggande orsakerna till denna starka reaktion? Syftet med studien är att undersöka vilka orsaker, såväl externa som interna, det är som styr den ryska inställningen.

In this paper I attempt to analyze the ways the European Union defines its external borders in cross-border co-operation with its neighbours. The analysis is based on case study examining the founding components of a updated version of the Northern Dimension policy of the European Union.The analytical framework of the study is composed of three different perceptions on the cross-border co-operation; regionalisation, integration and flexible integration. I conclude that the model of cross-border co-operation laid by the Northern Dimension policy would have an impact on the EU's external border with Russia, making it more flexible and vague.As far as the geographical terms of the co-operation are concerned, they seem to shift from regional co-operation to greater emphasis the role of networks as basis for co-operation instead of traditional regions..

Scania CV is one of the world's largest truck manufacturer. It is not only the directproduction of vehicles and methods that are important for Scania but also the servicemarket handling spare parts, repairs and workshops. The department Vehicle ServiceInformation construct standard times through work measurement for particularworks in the workshops. The software application STAM is used in the servicemarket to create and store standard times which then are exported to theworkshops' own systems.The purpose of this master thesis is to analyse and evaluate the internal workmeasurement system that includes standard times and the software STAM. Also,based on external analysis and benchmarking of other systems suggest appropriatefuture development within the area for Scania Vehicle Service Information.In order to perform the investigation, interviews and studies have been doneinternally at the departments that are involved in work measurement as well asexternally at Scania workshops.

Syftet med denna uppsats är att beskriva och analysera svenska myndigheters internrevision för att kunna dra slutsatser om i vilken ansvarslinje de befinner sig i dagsläget samt att föra en diskussion kring internrevisionens oberoende. I denna uppsats har en kvalitativ studie genomförts. Med hjälp av semi-strukturerade intervjuer på sex olika myndigheter med krav på internrevision har empiri insamlats som tillsammans med teoretisk referensram ligger till grund för analys och slutsatser. Studien visar att svenska myndigheters internrevision befinner sig i den tredje ansvarslinjen. Vissa variationer inom den tredje ansvarslinjen kan urskiljas på grund av dels otydliga riktlinjer för internrevisorerna för att kunna bibehålla ett oberoende i samband med råd och stöd och dels på grund av bristfälliga kunskaper i den andra ansvarslinjen avseende hur ansvaret ska fördelas. .

This is a study of the insect community associated to the wood-decaying fungus Inonotus radiatus found on Alnus glutinosa trees growing in riparian forests at the northern and southern shores of boreal lakes in the province Uppland. Little is known about this particular bracket fungus and its inhabitants. Insects were reared out at the laboratory from samples of fruiting bodies of the fungus taken at five lakes. During the fieldwork in 2009, data about several environmental variables was also taken. After the rearing period, these variables and their effects over the insects were analyzed.

Systems development methods mirror different organizational perspectives, and not all methods are formalised, but what they have in common is the purpose of structuring and supporting systems development processes. Which method would be the most suitable may be determined by the systems development context at hand, because every systems development context is unique. Information is a valuable asset in today?s organizations, and it needs to be protected against both internal and external security threats. In our essay we aspired to find and present suggestions as to how systems developers can include security in the very design based on formalised systems development methods to create systems that are better prepared to meet the security challenges of today.

Perch (Perca fluviatilis) is a very popular fish in Sweden and it is common in Swedish waters. In some areas along the Swedish coast the perch population has decreased. It is therefore important to get a view at the health status of perch. During April, July and August of 2008, a total of 346 perches were caught in the Gump Bay in the Botnian Sea. The fish were mainly caught by net but also by rod.

The Court of Justice of the European Union has progressively revised the rule of purely internal situations to ensure a wider scope of application of the economic freedoms as well as the EU citizenship right to move and reside freely within the Union. This development, combined with the increasing importance of fundamental rights, has strengthened the family life protection of those EU citizens who come within the scope of EU law. The limit between the individuals who may benefit from a EU right to family reunification and fundamental rights protection and those who find themselves in purely internal situations has, however, become more legally uncertain. The disadvantage suffered by those who fall outside the scope of EU law is known as reverse discrimination.The 2011 case Zambrano confirmed the trend towards an increasingly generous EU law protection of family life in cases where the exercise of freedom of movement and enjoyment of EU citizenship rights is potentially restricted by a Member State measure. By contrast, in the subsequent McCarthy- case, it became clear that families in purely internal situations may only rely on national immigration and procedural law to obtain family reunification and protection of their fundamental rights.

2005 was the year that all of the 25 member states in the European Union were to ratify the treaty of a constitution for Europe. The year did, however, offer a series of unexpected and slightly shocking events as both France and the Netherlands voted no to the constitution. Because of this the already planned referendums across many of the other member states were either postponed indefinately or the debates simply died down. The fact that two of the most pro-EU countries didn?t ratify the constitution was not only something that certainly raised the question of how future referendums in other, more EU-negative, states would turn out, but it could also be seen as harsh criticism against the EU as a whole.This is a theory consuming study, as it uses different theories of integration to explain the development of the EU, which in turn supports and strengthens the essay's conclusion.