Cycling is one of the most sustainable transport modes available and it is widely promoted inmany urban areas. The health benefits from cycling has shown to be substantial, includingdecreased risks of diseases related to overweight and enhancing brain capacity. However, inurban areas cyclists can temporaly be exposed to high levels of air pollution, resulting inhealth risks as opposed to health benefits.The objective of this thesis is to develop a rasterbased test model in GIS that estimates theinhaled dose of air pollution for cyclists based on relative particle concentration in differenttransportation micro-environments. The method used is a least-cost path approach,calculating three different routes; shortest, fastest and least dose for four different trips withinSödermalm, Stockholm.The results show that the inhaled particle dose can be greatly reduced, 39% - 58% for three ofthe routes, by choosing the least dose route. One of the most interesting findings is thesubstantial increase of dose when high levels of particles are combined with uphill cycling.The conclusion for the thesis is that a raster-GIS model can be very useful for estimating doseof different air pollution particles and chemicals along cycling routes.

The county of Dalarna is at present carrying through a process of digitalization where traditional x-ray film is being replaced with digital detectors. Earlier used methods for dose optimization turned out not being sufficient. This report presents a method to harmonize dose levels between x- ray sites equipped with Fujifilm imaging plate systems. An exposure index, S, related to the dose level of the examination is computed to every x-ray image. S turned out to be inversely proportional to the detector dose used at the examination.

Volvo Human Monitoring (VHM) is an ongoing project at Volvo Cars where they measure, amongst other parameters, inhalation and exhalation through a device called Respiratory Inductance Plethysmograph (RIP), on drivers. RIP measures changes in the cross-sectional area of the chest and abdomen. When the driver is in motion, such as when she is turning the vehicle, the cross-sectional area changes and noise in the RIP signal may arise.The noise results in a large number of manual adjustments in the analysis of the RIP signal, which is very time consuming and the validity of the device for measuring inhalation and exhalation is questioned.The purpose of this study was to improve the efficiency of the analysis of the RIP signal. The goal was to create a new data processing tool in Matlab that automatically detects inhalation and exhalation from a RIP signal with higher validity compared to the previous data processing tool.In this study, nine tests were performed on drivers while they were driving in different scenarios such as highway, country road and in city traffic. Inhalation and exhalation was measured using a RIP, a pneumotachograph with a tightly sealed facemask and a thermocouple placed between the nose and mouth, which was used as reference to the RIP.The result of this study was a data processing tool that automatically detects inhalation and exhalation with higher validity compared to the previous data processing tool.

Volvo Human Monitoring (VHM) is an ongoing project at Volvo Cars where they measure, amongst other parameters, inhalation and exhalation through a device called Respiratory Inductance Plethysmograph (RIP), on drivers. RIP measures changes in the cross-sectional area of the chest and abdomen. When the driver is in motion, such as when she is turning the vehicle, the cross-sectional area changes and noise in the RIP signal may arise.The noise results in a large number of manual adjustments in the analysis of the RIP signal, which is very time consuming and the validity of the device for measuring inhalation and exhalation is questioned.The purpose of this study was to improve the efficiency of the analysis of the RIP signal. The goal was to create a new data processing tool in Matlab that automatically detects inhalation and exhalation from a RIP signal with higher validity compared to the previous data processing tool.In this study, nine tests were performed on drivers while they were driving in different scenarios such as highway, country road and in city traffic. Inhalation and exhalation was measured using a RIP, a pneumotachograph with a tightly sealed facemask and a thermocouple placed between the nose and mouth, which was used as reference to the RIP.The result of this study was a data processing tool that automatically detects inhalation and exhalation with higher validity compared to the previous data processing tool.

The county hospital of Dalarna has for the last couple of years carried through a process of digitalization. The result is that within the county it exists image plate systems from two different manufacturers. In an attempt to create a tool for dose optimization and dose surveillance the county of Dalarna would like to investigate if the exposure index from Agfa and Fuji is suitable as a dose indicator. An investigation of the exposure index, S, from Fuji has already been done. This thesis has been continuing the investigation by evaluating the stability of the exposure index, lgM, from Agfa.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

Bronchiolitis is a common performance decreasing disease in horses (Bracher et al, 1991¸Dixon et al, 1995) Its medical treatment includes inhalation therapy with corticosteroids and b2-adrenoceptorer stimulators. Use of both these medicines is prohibited for sport horses and athletes. Because the facemasks used for inhalation therapy are not airtight, there is a risk for leakage of these medicines. We wanted to see if cross exposure of nearby horses can result during normal recommended treatment of a horse, and assess if this could result in doping positive urine sample from the person treating the horse and from horses in the same airspace. We did a pilot study with four healthy horses. The experiment was divided into four parts.

Eight healthy 3-day-old foals were given repeated injections of trimethoprim-sulfadiazine intravenously for 3 days, at a dosage of 15 mg/kg bodyweight (2,5 mg trimethoprim and 12,5 mg sulfadiazine). Blood samples were collected prior to each administration and for the following 24 hours after last administration. Serum concentrations of trimethoprim and sulfadiazine were measured and the pharmacokinetics for the substances were studied. The elimination half time (t½) and clearance (ClB) for trimethoprim and sulfadiazine for the foals did not diverge from adult horses. According to these data it is possible to assume that the same dose interval and dose can be used for foals as for adult horses.

This diploma work was performed at the department for radiation physics at the Health University in Linköping. Its aim was to develop a method to retrospectively quantify the absorbed dose in coral. Coral is a material which suites well as a retrospective dosimeter because when exposed to radioactivity its induced free radicals are stable in time. The number of radicals is proportional to the accumulated dose so the dose can be calculated by quantifying the radicals. Therefore, coral can tell us something about the past environment and also be used in dating purposes.A young, modern coral from the Red Sea was studied and also a fossil one which I was given from the Natural History Museum in Stockholm.

This thesis presents a system which has been implemented to satisfy a need in theresearch on how speech planning interacts with syntactic and prosodic structure inspontaneous speech. The long-term purpose of the research is to provide models forautomatic parsing of spontaneous speech and for psycholinguistical modelling of speechproduction. Identification of inhalation pauses is an important step in the developmentof automatic methods for spontaneous speech parsing.Identification of inhalation pauses is considered to be a keyword-spotting speechrecognition problem. Hybrid HMM(Hidden Markov Models)/ANN(Artificial NeuralNetworks) approach is applied to this problem. Method gets 90,8% in Recall, 66,4% inPrecision and 76,7% in F-score.

This thesis for the Master of Science degree was performed at Oppunda Electronics AB. The assignment was to further develop an existing prototype of a dispensing equipment. The dispensing equipment doses a kind of glue, bonding which dentist use to mend teeth. The dispensing equipment is adjusted to dose 12 micro litres of bonding. With the dispensing equipment SafeBond Electronic the user can reduce the bonding consumption with approximately 50 percent.

Rabbits carry a high risk of anesthesia related death. This study was part of a project to develop a form of total intravenous anesthesia (TIVA) with minimal effects on cardiac, respiratory and metabolic parameters. In the study, TIVA with sufentanil and midazolam (group TIVA, n=9) was compared with inhalation anesthesia with sevoflurane (group SEVO, n=9) in female rabbits undergoing surgery (ovariehysterectomi). All rabbits were pre-medicated with medetomidin and carprofen before anesthesia induction. Anesthesia was induced with TIVA (2.3 ?g/ ml sufentanil, 0.45 mg/ ml midazolam) at a rate of 4 ml/ kg/ h and the mean induction dose was 0.4 ?g/ kg of sufentanil and 0.1mg/ kg of midazolam.

I händelse av ett radioaktivt utsläpp är det viktigt att ha bra beredskap med skyddsåtgärder som bidrarmed det bästa skyddet för den utsatta delen av befolkningen. Direkt efter ett utsläpp utgör exponering viainandning det största problemet eftersom partiklar och gaser ännu inte hunnit deponerats på mark, imoln och så vidare. Byggnader bidrar med ett skydd mot inhalation eftersom luften utanför och inutibostaden byts ut relativt långsamt. Hur stor del av föroreningen som tar sig in till inomhusluften och hurlång tid detta tar är viktig information för att avgöra om befolkningen är tillräckligt skyddade inutibyggnader eller om evakuering bör ske. I detta arbete har kunskap från befintlig litteratur samtmodellering använts för att beskriva generella förhållanden med vilka en förorening kan ta sig in i och utur en byggnad.

Methadone is frequently used as an analgesic drug for dogs although there are very few studies describing the pharmacokinetics of methadone in this species. In man methadone has a long half-life and there are considerable differences in pharmacokinetics between individuals. The dose interval is lengthened when the drug is used fore longer periods of time due to prolonged half-life. Therefore the drug dose must be adjusted individually. The purpose of this study was to study the fundamental pharmacokinetics of methadone in dogs, and to find an optimal drug dosage.