Atopic dermatitis (AD) is a complex, often lifelong allergic disease affecting around 10 % of both dogs and humans. The hallmark symptom is severe pruritus, causing a lowered quality of life. Mast cells (MCs) are known to play an important part of the immunopathogenesis, promoting a faulty T helper cell type 2 (Th-2) response which follows by a production of specific immunoglobulin E (IgE) antibodies towards environmental allergens (Ag). To further investigate the role of MCs and its mediators in the progression of AD, a low-calcemic vitamin D3 analog (MC903) was used to induce AD-like symptoms locally on the ears of two different knock-out (KO) mouse strains. The first strain was Wsh-/- mice deficient in MCs.

Retinoscopy, also known as skiascopy, is an objective method for assessing therefraction of the eye. This method has been used for a long time, both in animalsand human patients. According to the literature, it has been postulated that it is notnecessary to obtain cycloplegia before the examination in lower mammals. Someauthors even mention that it can make the examination more difficult. Therefore itis not recommended.

Constraint-Induced Aphasia Therapy (CIAT) är en gruppbehandling för personer med afasi. Tidigare forskning kring CIAT har ansetts otillräcklig gällande dess långsiktiga effekt, dess effekt vid lindrig afasi och dess effekt på kommunikativ delaktighet. Föreliggande studie är en multipel fallstudie som syftar till att undersöka CIAT:s kort- och långsiktiga effekt på språk och kommunikation vid lindrig afasi. Fyra personer med kronisk afasi deltog i CIAT under två veckor. Språkfunktioner och funktionell kommunikation bedömdes före behandling (T1), efter behandling (T2) och vid uppföljning efter 3 månader (T3). Bedömningarna kompletterades av intervjuer med deltagarna och deras närstående. Vid T2 visade samtliga behandlingsdeltagare övervägande förbättrade språkliga funktioner. Vidare skattade 4/4 deltagare och samtliga närstående en förbättring av funktionell kommunikation. Vid T3 var förbättringen övervägande stabil.

This diploma work was performed at the department for radiation physics at the Health University in Linköping. Its aim was to develop a method to retrospectively quantify the absorbed dose in coral. Coral is a material which suites well as a retrospective dosimeter because when exposed to radioactivity its induced free radicals are stable in time. The number of radicals is proportional to the accumulated dose so the dose can be calculated by quantifying the radicals. Therefore, coral can tell us something about the past environment and also be used in dating purposes.A young, modern coral from the Red Sea was studied and also a fossil one which I was given from the Natural History Museum in Stockholm.

Causes of thrombocytopenia in dogs ? a retrospective study of 123 cases The purpose of this retrospective case study was to determine which diseases are associated with thrombocytopenia in Swedish dogs. Records of 123 dogs with thrombocytopenia were evaluated. The most common cause was neoplasia-associated thrombocytopenia (32%). The largest proportion within this group was unspecified neoplasia.

This study was a degree in Master of Science in agriculture with specialization in animal science for the Department of animal nutrition and management at SLU. The subject was created by AS-Faktor, a small company for science and development within the company Lantmännen AB. It was a test of the effect of SPC (Special Processed Cereals) on induction of the endogenous protein AF (an antisecretory factor) in plasma and intestinal lumen in broilers. Previous results have shown positive effects on different intestinal diseases in pigs, horses, dogs as well as in humans. Beside the induction we also studied the effects on results in a conventional slaughter chicken production, including the ability of SPC to compete with or be affected by the coccidiostat, Salinomax.When diarrhoea occurs, it's because there is an imbalance between the secretion and the absorption and it can be caused by for example toxins.

The problems with train-induced vibrations are increasing with heavier and faster trains. Therefore the work with propagating vibrations is of outmost importance, and that is what this thesis relates to.To get a sensible idea of the propagation, calculation models are often used. Propagation calculation models takes into account factors such as distance to the railway, the ground material and the velocity and weight of the train. This work is mainly about finding suitable existing models and, if necessary, adjust them to be more useful with modern trains and railways.The report contains the work of adjusting one such model and does, despite the fully functional adjusted model, describe how much more there can be done within this topic. Finally, a few tips about specific areas that preferably should be studied to get even further knowledge about the troublesome problems from railways..

Examensarbetets målsättning var att studera de materialrörelser som uppkommer i direkt anslutning till stranden genom påverkan av fartygsvågor. Intressant var just att studera sådant material som Daleke et al (1989) finner en överensstämmelse med ? mellan sina iakttagelser och en felaktig version av Hjulströmskurvan ? men även annat material skulle studeras. Arbetet utfördes i Furusundsleden och i farleden vid Lidingö där trafiken av Finlandsfärjor är tät.I farleder som till vattenvolym är begränsade uppstår kraftiga vattenrörelser, sugeffekter förutom de vanliga svallvågor som bryter mot stranden. Dessa båda typer av vattenrörelser påverkar materialet längs stränderna..

Methadone is frequently used as an analgesic drug for dogs although there are very few studies describing the pharmacokinetics of methadone in this species. In man methadone has a long half-life and there are considerable differences in pharmacokinetics between individuals. The dose interval is lengthened when the drug is used fore longer periods of time due to prolonged half-life. Therefore the drug dose must be adjusted individually. The purpose of this study was to study the fundamental pharmacokinetics of methadone in dogs, and to find an optimal drug dosage.

Superior Canal Dehiscence Syndrome (SCDS) is a newly described syndrome with symptoms including sound- and pressure induced vertigo, conductive hyperacusis and autophony. SCDS is caused by absence of bone overlying the superior semicircular canal and can be surgically treated. As the syndrome and surgical technique is new, it is of importance to study possible postoperative outcomes..

Hur vi människor förhåller oss till dåtid, framtid och nutid avspeglar vår personlighet och kan länkas samman till vårt psykiska mående. Denna studie syftade till att studera sambanden mellan tidsperspektiv, depression och ångest samt oro och ältande. Vidare ämnade studien att undersöka om en bristande inhiberingsförmåga kan förklara oro och ältande. I studien deltog 65 personer från en icke-klinisk grupp; 44 kvinnor och 21 män i åldrarna 19 till 40 år. De instrument som användes var självskattningsformulären Swedish Zimbardo Time Perspective Inventory, Beck Depression Inventory-II, Beck Anxiety Inventory, Response Style Questionnaire, Pennstate Worry Questionnaire samt Strooptestet Serialt färgordtest.

The purpose of this study is to extend the understanding of how professionals in modern organisations want to be managed. We especially investigate professionals changing industries to describe if, and how, aprofessional in this situation is becoming a professional again after the change. This to find connections between intrinsic motivation and attitudes towards professionalism on one side, and applicable managerial methodson the other. Best practice in managing professionals is traditionally considered to be non-invasive methodologies such as indoctrination and training. Beyond that, operational-level management is usually considered to be bound to fail.The analysis suggests the following:? A professional changing industry will become professional again.? The driving force for becoming professional again is the strive for horisontal specialization, induced by higher education.? Management of professionals needs to account for the integrity of the horizontal specialization of the professional.

The treatment that women get from health care staff can influence the experience of the abortion and how women manage to coping the experience emotionally. The aim of this study was to illuminate women?s experiences in connection with an abortion. The findings show that the women?s social situation led them to the decision of abortion.

An inflammatory reaction is induced after release of proinflammatory mediators such asinterleukin 1 and 6 and tumour necrosis factor ?. These mediators stimulate the liver tosuppress the syntheses of albumin and endure the syntheses of acute phase protein forinstance C-reactive protein. The aim of this paper was to perform a method validation on animmune turbidimetric assay to quantify C-reactive protein in canine serum at the laboratory atSkara Animals Hospital, Skara, Sweden. The validation involved evaluation of the assaylinearity, precision, stability and recovery.The method was proved to be linear for both TruLab control and Medinor control.

Diabetes mellitus is a rising epidemic throughout the world and there is currently great interest in quantifying the beta-cell mass (BCM) in vivo non-invasively. In the present experiment, the feasibility of in vivo imaging of the glucagon-like peptide-1 receptor (GLP-1R) in beta-cells was examined, using the positron emission tomography (PET) tracer [68Ga]Ga-DO3A-VS-Cys40-exendin-4 as a marker, in native pancreatic beta-cells of a porcine diabetic animal model and healthy controls. Eight Swedish high-health domestic pigs were randomly assigned to be either controls or made diabetic using streptozotocin (STZ). The experiment proceeded during eight weeks, starting with an acclimatisation period. Once the pigs had been socialised they underwent surgery for the insertion of a jugular vein catheter, allowing induction of diabetes with STZ, intravenous (i.v.) injections and stress-free blood sampling. Development of diabetes was confirmed by clinical examinations, blood glucose values and insulin-staining of pancreatic sections post mortem. The diabetic pigs were insulin treated and responded well.