Cystisk fibros (CF) är en kronisk, ärftlig sjukdom, som framför allt drabbar lungorna och kan p.g.a. påverkan på dessa leda till för tidig död. I Sverige är ca 650 personer drabbade av cystisk fibros och det föds runt 20 barn med CF i Sverige varje år.CF beror på förekomst av en eller flera mutationer i genen för Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), vilket leder till defekt CFTR och därmed till rubbad jontransport över cellmembranet. Det finns idag inget botemedel mot CF. Fram till nu har behandlingarna av CF riktats mot sjukdomens symtom.

Cystisk fibros (CF) är en kronisk, ärftlig sjukdom, som framför allt drabbar lungorna och kan p.g.a. påverkan på dessa leda till för tidig död. I Sverige är ca 650 personer drabbade av cystisk fibros och det föds runt 20 barn med CF i Sverige varje år.CF beror på förekomst av en eller flera mutationer i genen för Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), vilket leder till defekt CFTR och därmed till rubbad jontransport över cellmembranet. Det finns idag inget botemedel mot CF. Fram till nu har behandlingarna av CF riktats mot sjukdomens symtom.

In times of increased flooding, enhanced by climate change, polluted stormwater poses an increased threat to the environment through contaminated water entering waterways. Bioretention utilizes natural processes in soil and vegetation to treat pollutants and combat this threat. Biochar produced through pyrolysis, has a high cation exchange capacity (CEC) and could therefore increase treatment in bioretention systems. This research applies a literature review, interview, and a model to explore the benefits and disadvantages of biochar in order to specify a soil-mix through an understanding of the production process and preferred application rate. High purification through CEC, increased water holding capacity, and carbon sequestration being the benefits discussed.

Volvo Construction Equipment is one of the worlds largest manufacturer of heavymachinery. In Braås, Sweden, they develop and manufacture articulated haulers inseveral sizes. The biggest, the A40, is capable of loading almost 40 metric tonnes.These haulers have a bogie to distribute the forces of the load evenly onto the two axlesand there wheels. The bogie is constructed using a rigid balance beam on each side ofthe frame connecting the axles or an independent solution using hydropneumatics.An analysis has been made in order to establish the forces created during corneringand through the theory, an estimation of the extensive tyre wear and extra fuelconsumption has been made. All due to the effects of the tyres not being inline with thecornering radius.

This thesis considers the development of the software for an, newly developed, embedded real-time control system, based on a Periferal Interface Controller (PIC). The control system is developed to be used for several different applications. In this thesis work, software for two different applications are developed. The first task is a time controlled system, while the other task is implementation of aPI-/PID-controller. A user interface is also developed and implemented.The time controlled system is an automatic horse feeder, which is used for feeding horses at certain predefined points in time.

Metso Paper offers a front-running range of solutions and services for the pulp and paper industry. At the baling unit, design solutions are developed for manufacturing and handling of pulp bales. The machines are continuously developed to satisfy customer needs. One big step in the development of the baling line was to remove hydraulics from the machines and replace it with electrical motors and pneumatics. This was not done on the folding machine which is still driven by mainly hydraulics.

Swedish agriculture has gone through big changes in the latest 60 years. The farm sizes have increased, which has led to raised tractor and machinery sizes and therefore increasing problems with soil compaction. A method to reduce these problems is to implement controlled traffic farming, CTF. All field operations are then concentrated to specific tracks by using GPS guidance. The aim of this work was to study how the tillage regime, with or without CTF, affects the soil, with the main focus on macroporosity. In Säby close to Uppsala, and Alnarp close to Malmö, randomized block trials has been carried out, and the data has mainly been taken from these trials.

Flooding events are no longer rare, floods occur all over the world. Accordingly, it is vital for the society and different authorities to work with flood mapping. To meet the goal of Uppsala kommun to map the risks of floods in Uppsala län, a map of the different areas around Funboån which are inside the area of risk for flooding have been developed.In the work, cross sections and the water flow have been measured. Moreover, an echo-sounding have been carried out in Funboån to map the bottom topography. From the bottom map and laser scanned data covering the study area, a terrain model was created.

The purpose of the thesis was to map the hydraulic load on the Knivsta river from stormwater runoff, and build a platform for further studies of pollution loads on the rivers ecosystems. New residential areas are planned to be built in Knivsta municipality and it will have an impact on stormwater flows to Knivsta river. To examine the impact this will have, simulations were made in the area as it stands today and after expansion work. The work includes calculation of flows from the populated areas but also from the catchment area around it consisting of woodlands and fields. Because of expected climatic changes which may affect rainfall, the simulations have been performed with different return periods for rainfall data.

GBD-Storage Systems is a company that provides the industries with products for efficient storage.The company produces pallet racks and accessories like cassettes and extending units. The companyhas also supplied tire racks for a number of tire companies. The company's CEO Gunnar Berglund hasfor some time had an idea to improve the working situation of the workers on tire firms by allowingthe wheels to be handled by a counterbalance truck. The current situation poses numerous heavy liftswhen the tires are handled and therefore is hurting the workers.This thesis has been aiming at helping the GBD-Storage Systems by developing a concept of howan accessory to counterbalanced trucks can be designed to cope with the wheels. This concept willthen be produced as prototype by the company.

The task was to design and manufacture a submersible displacement pump working with the wobble plate principle. The main task for the Wobble plate pump is to be used as a sewage pump for smaller households or dewatering pump in environments where small flows and high pressures are acquired. For these purposes ITT Flygt sell a screw pump, PC-Grinder 3068. The hydraulic part of the PC-Grinder is manufactured by a subcontractor. Therefore ITT Flygt wants to evaluate an alternative to their screwpump PC-Grinder, which can be entirely manufactured by them self.

During year 2004 Ålö AB made significant change in their production process. The production of front loaders is nowadays highly automated with short operation times. To be able to control their process in a better way Ålö recently decided that they needed a tool for simulation of their production and to shift patterns. This final thesis started with a pilot study in Ålö?s factory in Brännland.

Delineation of recharge areas for aquifers is performed in the groundwater mapping process at the Swedish geological survey, SGU. This work is time consuming and performed manually. It is therefore desirable to develop a more general and repeatable method for defining recharge areas for aquifers.The purpose of this study was to investigate two other possible methods to delineate recharge areas for aquifers. The first method was to examine the possibility of using the topography of the bedrock to define the recharge areas for aquifers. To enable this, a method for generating the topography of the bedrock was developed.

Many traffic incidents are due to the driver?s lack of attention, resulting in dangerous lane departures, either sliding off theroad or into the oppose lane. These kinds of incidents often have serious outcomes, which has led to much effort being concentrated on preventing or lessening the damages when the incident is already a fact, for example by installing safety belts and air bags. These measures may be considered to be acts of so-called passive safety. Active safety on the other hand, means that the safety systems intervene before the incidents have occurred.

The purpose of this thesis is to investigate the fatigue life of two components in different hydraulic quick couplings. The crack which initiates the fatigue failure usually occurs in the bottom of one of the threads. Thus, the threads in the coupling are carefully investigated. A few different approaches for determining the fatigue life are studied for each component. CAD (Computer Aided Design) models for both components are created and analyzed with FEM (Finite Element Method).