Serum thymidine kinase 1 (TK1) activity is used as a tumor marker in disease monitoring in veterinary and human medicine. TK1, an intracellular enzyme, is involved in a salvage pathway of DNA precursor synthesis. TK1 is used in DNA precursor production by catalyzing the transfer of the gamma-phosphate-group from a phosphate-donor to the 5?- hydroxyl-group of thymidine forming thymidine-monophosphate. Nucleoside monophosphosphates are finally converted into thymidine-triphosphates. TK1 activity significantly rises in the G1 and the S phase of the cell cycle.

The goal of this work has been to search historical materials, to identify the park's historical development, to prepare proposals on measures and that work should be the basis for further research. The aim has been to train us in searching for and use of materials and to gain an understanding of the process of work with older plants. In the process we have sought and found materials in archives, through literary and oral sources, and email contacts. Because of its excellent location perched on an islet in the low landscape Näsbyholm was long a fortress. The old castle on Näsbyholm was from the late 1400s but the site was fortified much earlier. The islet was at this time completely surrounded by water and there was a drawbridge over the narrow waterline. The owners are liable since the late 1200s.

SAMMANFATTNING Rinnande vatten har över en lång tid spelat en väsentlig roll för landskapets geomorfologiska processer och utgör viktiga livsmiljöer för djur och växtsamhällen. Vattendrag har bidragit till människans utveckling och välstånd. Sedan urminnes tider har vattendrags miljöer nyttjats som boplats, för vinning av energi, transport och fiske. Likt allt liv på vår planet är människan beroende av vatten. Betydelsen av vattendragen, som del av den hydrologiska cykeln, kan därför inte betonas nog. Genom mänsklig aktivitet har dock rinnande vattens egenskaper och landskapsbilden som helhet i många områden förändrats drastiskt.