Propofol is an intravenously administered, hypnotic and short- acting pharmaceutical. One common sideeffect (>1:10) and therefore a disadvantage with propofol is the local pain that arise when the initial injection is given. Why the pain arise is not clearly understood. A majority of different pharmacological treatments, different doses and combinations, alternative administrations methods and physical interventions have been tried to reduce the pain when injection of propofol is given. One important task for the nurse is to relieve pain for patients.

In this study the opioid buprenorphine was given to 8 clinically healthy goats. The pharmacokinetics and behavioral effects were studied. Injections of buprenorphine, 0.02 mg/kg body weight was given both intramuscularly (i.m.) and intravenously (i.v.) with a cross over design. The results showed a short half-life of the drug in the plasma, 65.9 ± 17.4 min (mean ± SD), after i.v. injection.

In veterinary medicine, penicillin is the most used antibiotic in Sweden. Two dosage forms of penicillin are available in Sweden for use in horses, sodium benzylpenicillin (Na-pc) and procaine benzylpenicillin (proc-pc). Proc-pc is the most used dosage form and is used for intramuscular administration which allows horse owners to treat an animal at home under veterinary instruction. Na-pc is only approved for intravenous use in horses. Penicillin is normally well tolerated by horses but a serious, sometimes life-threatening, adverse reaction called penicillin shock may occur.

This study has been made to evaluate if there is a significant difference between non-estral intact versus ovariohysterectomized queens in their production of estradiol after exogenous gonadotrophin-releasing hormone stimulation. The purpose is to find a tool, which can help to diagnose if a free-roaming queen is already ovariohysterectomized or not. There are also other situations where this tool could be useful, for example to diagnose the ovarian remnant syndrome. Previous studies in bitches have shown that GnRH-stimulation is an excellent tool to diagnose the presence of ovaries in the bitch. Eleven ovariohysterectomized and eleven intact queens have been included in this study where we have analyzed plasma estradiol and progesterone concentrations before and after a single intramuscular injection of the GnRH agonist buserelin (Receptal?).

Intramuscular injections to cats can generate strong reactions in some individuals while reactions of the same extent, according to the author, not always are recognized when using the subcutaneous route. The reactions are probably caused by fear, stress and/or pain. When the injection can generate pain one has to take that into account, which can be a limitation in treatment. It is well known that injections generate pain, but knowledge about the cause and processes of the injection-associated pain is limited. This is mainly due to the difficulty in finding objects to study pain on, high cost of use of laboratory animals and difficulty to obtain objective measurements. Although there is evidence that there may be a local muscle injury by intramuscular injection, it is not always that the extent of damage is related to the pain experienced. Facts about the causes of injection-associated pain have been studied in a literature review.

Oxytocin is today widely spoken of as a "feel good" hormone. Recent research has increased interest in the hormone and its role in social and sexual interactions, as well as its importance for complex behavioral patterns. There is evidence that oxytocin is released during physical contact and is said to suppress anxiety and stress. In animals and humans, oxytocin, which is a neuropeptide and likewise a hormone, is necessary for parturition and lactation. Synthesis of oxytocin occurs in brain neurons and in specific organs involved in reproduction.

The work covered in this report includes a literature study of the diesel dual fuel technology(hereinafter referred to as DDF). The literature study covers earlier work that has been doneregarding the use of compressed natural gas (CNG) and diesel in a DDF system. Moreover a onecylinder research diesel engine was fitted with a CNG fuel system for experimental testing. Theinstallation of the engine and the test cell is described. Results from the tests are presentedcovering emissions, heat release and pressure traces from the DDF-concept.During the literature study it was found that most research was related to heavy duty dieselengines.

The aim of this study was to explore transsexuals? identity formation and experiences related to cross-sex hormone treatment, as well as to become absorbed in the narrative approach. To be able to participate in transsexuals? identity formation, life stories were well suited as a theoretical approach. Life stories can be seen as socially situated actions according to Mishler, where individuals? identity formation can be seen as both identity performances and identity claims.

A one-cylinder research engine has been used for studies with a Diesel Dual Fuel concept (DDF). DDF is a concept that utilizes a pilot diesel injection to ignite a homogenous natural gas/air mixture. Emissions and engine efficiency have been analyzed in an emission cycle called European Stationary Cycle (ESC) and the knock/pre-ignition problems with this type of engine have been investigated.At low and mid torque levels, an early diesel injection around 60 crank angles degrees (CAD) before top dead center (TDC) was used. At these loads raw NOxemissions was below EURO 6 level (0.2 g/kWh). NOxwas at EURO 5 level over the complete ESC without after treatment and with SCR at high loads it should be possible to reach EURO 6.One issue with DDF is the high HC emission levels.

The environmental requirements and laws on combustion engine emissions are very tough today andthey will become even more stringent in the future. To achieve these requirements there are highdemands on the control systems for these engines. An improved precision in the measurement of anengine's speed and position gives the electronic control system an even better timing when it comes tofuel injection and ignition. This makes the engine more fuel efficient, reducing the emissions. This thesisis part of a collaborative project between Hoerbiger Control Systems and subsidiaries.

Mastitis, inflammation in the udder tissue, caused by S. aureus is a big problem in dairy cattle production. It causes suffering for the cow and curing or replacing the infected cow is costly for the farmer. It is known that beef cattle also suffer from mastitis caused by S. aureus.

The aim of this thesis is to improve the control of urea injection at the combined power and heating plant Framtidens Gärstad (FTG). Tekniska Verken i Linköping AB is the owner of the plant.The FTG plant consists of a boiler where garbage combustion is done. From the combustion nitrogen oxides are emitted. These nitrogen oxides are hazardous to the environment. To reduce the nitrogen oxides, injection of urea into the boiler is used.

Picropodophyllin (PPP) is an analogue of the anti tumour lignan podophyllotoxin with the unique ability to selectively inhibit the receptor of Insulin like growth factor 1(IGF-1). IGF-1 is believed to play an important part in development of the endometrium facing implantation. With PPP treated mice, studies can be made to measure gene expression from tissue of both treated and untreated mice to compare the role of IGF-1 regarding ovulation, implantation and receptivity. The aim of this study was to analyze gene expression of some steroid hormone receptors and cytokines in ovaries from mice treated with PPP. In this study, seven mice were treated with PPP at different times and tissue was collected.

This thesis describes redesign and adaption of a products housing. In order to make it more economical to produce at a lower production volume. The thesis is based upon a prototype that a previous student developed for injection moulding. The goal is to find alternative manufacturing methods, but also to identify parameters that affect the cost of the injection moulding tool.The housing must be tough in order to protect the circuit board inside. But at the same time it must allow sound, light an electrical communication to pass through.

Att leva med diabetes kan vara krångligt då det hela tiden krävs planering av aktiviteter, måltider och medicinering. Sjukdomen behandlas framförallt med insulin som kan förekomma i pump, sprutor och injektionspennor. Det vanligaste sättet att injicera insulin är med pennor, och antalet pennanvändare ökar årligen. Insulin har stränga förvaringskrav och är känsligt mot hög värme, starkt ljus, skakningar och frysning. De personer som lever i länder där temperaturen över- eller understiger säkert förvarings-intervall har ett behov av att skydda sin medicin, men också resande till utsatta platser drabbas.