Promoters are Genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

ABSTRACTThe aim of this study was to give an overview of the evidence for genomic imprinting in livestock and other mammals as well as outline the potential use of gene imprinting in livestock breeding. EpiGenetics is the mitotical and meiotical partial hereditary variation in genomic activity without any alterations of the DNA sequence. An example of epiGenetic regulation is genomic imprinting where one allele?s expression differs depending on which parent it was inherited from. These parent-of-origin effects are currently overlooked in livestock production.

Promoters are Genetic elements that facilitate the transcription of a gene and they have been found in front of non-coding RNA (ncRNA) genes in different organ-isms, e.g. the model plant Arabidopsis thaliana. A similar element, DUSE, has been found in front of ncRNAs in the social amoeba Dictyostelium discoideum and a part of this project has been to analyze the function of this putative promoter element through cloning and expression studies. A construct to analyze the func-tion of DUSE was successfully designed and introduced into D. discoideum but full expression studies were not finished because of shortage of time.

A vulnerable group in society is people with ASD (autism spectrum disorders) or autism. This group seems to increase, mainly due to Genetic factors but also environmental problems. Medical research has accelerated in the U.S. and Europe. The biggest problem for people with disabilities is the inability to communicate, both verbally and socially.

Denna litteraturstudie behandlar strålbenshälta hos häst, även känd som Navicular disease (ND). Studien beskriver sjukdomen och dess karaktäristiska drag, samt belyser de två huvudsakliga teorierna om den bakomliggande orsaken till insjuknandet. Det finns tydliga inklusions- och exklusionskriterier, vilka är viktiga för att kunna göra en omfattande hältutredning och för att kunna ställa rätt diagnos, som är betydande för att ge rätt behandling. Litteraturstudien belyser även det faktum att hästar drabbade av ND har visat sig ha högre intramedullärt tryck i strålbenet, samt vilka genetiska riskfaktorer som visat sig vara kopplade till sjukdomen. De genetiska defekter som behandlas är röntgenförändringar i strålbenskonturen (RAC) och strålbensstrukturen (RAS), samt utvecklandet av deformerade näringsfåror i strålbenet (DCS).

A vulnerable group in society is people with ASD (autism spectrum disorders) or autism. This group seems to increase, mainly due to Genetic factors but also environmental problems. Medical research has accelerated in the U.S. and Europe. The biggest problem for people with disabilities is the inability to communicate, both verbally and socially.

The ability of dairy cows to survive and the economic importance of this have been in-creasing in dairy cattle breeding lately. Increased longevity contribute to an increased pro-portion of cows that produce milk in more productive lactations and reduces the replace-ment costs together with a good health and fertility. Unfortunately it is often argued that longevity has been decreasing due to a strong selection for production traits in dairy cattle.The aims of this study were to find correlations between different longevity evaluations and between different estimates on longevity and other traits in the Nordic Total Merit (NTM) breeding value. The aim was also to compare different traits for cows of two differ-ent longevity groups.The data were Predicted Breeding Values (PBV) from Nordic HOL and SR bulls and records from Holstein (HOL) and Swedish Red (SR) cows estimated by the Swedish Dairy Association.The three Swedish longevity indexes were very highly correlated (>0.89) and the corre-lations between the Swedish official longevity index and the five Nordic Cattle Genetic Evaluation (NAV) longevity indexes varied between 0.73-0.83.In the sire evaluation part, the traits most negatively correlated with longevity for HOL were dairyness, protein and fat index. In SR, milk, protein, and fat index only had slightly positive correlations with longevity.

Man har förr trott att fågelpar inom många arter, t ex albatrosser och kungspingviner, är varandra trogna livet ut. Syftet med denna litteraturstudie är att ta reda på om det finns något vetenskapligt stöd för sexuell eller genetisk monogami hos någon fågelart. Uttrycket ?monogami? kan ha flera betydelser. Social monogami är att en individ lever i ett parförhållande med endast en partner åt gången. Sexuell monogami innebär att ett par kopulerar bara med varandra, och detta baseras på observationer.

Sarcoid is the most common tumor in horses all over the world. The sarcoid is a benign, locally invasive, usually fibroblastic proliferative skin neoplasm. Even if the etiology is not completley verified, the epidemiology and clinical behavior suggest a infectious intervention, probably BPV type 1 or type 2. However, it is known that the cause is multifactorial. A Genetic prepdispositon has been identified associated to genes within the Major Histocompatibility Complex (MHC), but also to breed, age and perhaps gender.

Sarcoid is the most common tumor in horses all over the world. The sarcoid is a benign, locally invasive, usually fibroblastic proliferative skin neoplasm. Even if the etiology is not completley verified, the epidemiology and clinical behavior suggest a infectious intervention, probably BPV type 1 or type 2. However, it is known that the cause is multifactorial. A Genetic prepdispositon has been identified associated to genes within the Major Histocompatibility Complex (MHC), but also to breed, age and perhaps gender.

Equine metabolic syndrome (EMS) it?s a clinical condition that includes obesity, regional adiposity, insulin resistance (IR) and laminitis. A similar syndrome exists in human medi-cine, the metabolic syndrome (MS), were systemic hypertension also is a prominent fea-ture. The systemic hypertension seen in humans with MS is partly due to a vascular endo-thelial dysfunction with an enhanced endothelin-1 (ET-1) mediated vasoconstriction. There are indications that systemic hypertension might be a feature in EMS as well but if ET-1 is involved in the development of the systemic hypertension in horses is not known.

The life cycle of the anadromous Atlantic salmon (Salmo salar) can span large geographic, political, and socio-economic boundaries. Management strategies and regulations that only concentrate on small spatial scales often overlook larger basin-wide problems, especially relating to post-spawn seaward migration. In this master thesis one entire migration cycle of wild adult Atlantic salmon in the unregulated northern Swedish river Vindelälven was monitored by radio-telemetry tracking during upstream spawning migration and downstream seaward migration back to the Baltic Sea. The effect of ladder passage variables (time to pass, total time in the ladder, passage day over the ladder) at a fish ladder downstream in the river Umeälven, as well as fish size, were evaluated to determine if differences in upstream migration distance in the river Vindelälven could be observed. Ladder passage variables did not affect migration distance, but size exhibited a negative relationship to migration distance.

In Europe poplar plantations has been planted for more than one hundred years. In the first plantation was made in 1940. The interest for poplars has since then shifted over the years and has for long periods been very low but is now slowly increasing again. The main reasons why poplars are becoming more interesting are because of their great production potential. Nevertheless, the knowledge of how to mange poplars in Sweden are very low and very little research has been done concerning management of the species. The objective for this study was to; 1) investigate and document experience and results obtained in practical Swedish forestry, 2) to give a fair picture of the perceived advantages and disadvantages that the poplars has for the forestry, 3) document what the foresters that has experience and those who has no experience of poplar plantations thinks about the potential of poplars.

Den vanligaste produktionsformen av nötkött sker i dikobesättningar, där kor och kvigor förväntas föda en kalv per år. I sådana besättningar är fertilitet hos djuren en viktig faktor, då förmågan att föda fram en kalv varje år påverkar inkomsten. I Sverige används naturlig betäckning i störst utsträckning, men ett alternativ är artificiell insemination. Syftet med detta arbete är att undersöka för- och nackdelar med artificiell insemination och varför det inte används i samma utsträckning inom dikobesättningar som hos mjölkkor, samt när det kan vara aktuellt att använda sig av. Den artificiella inseminationens påverkan på dräktighetsresultat varierar mycket i studierna, från 37 till 74 %, men det antyds att 50 % är ett gränsvärde där resultat över detta kan anses godtagbara. Ekonomiskt finns fördelar så som ökade kalvvikter och mindre förluster relaterat till kalvningssvårigheter, men nackdelar i form av ökade kostnader för veterinärtjänster och mediciner samt för arbete.

Porcine circovirus type 2 (PCV2) is a common virus present in most parts of the world. PCV2 has been pointed out as the major causative agent to post weaning multisystemic wasting syndrome (PMWS) that affects pigs after weaning. The clinical symptoms of PMWS are impaired growth, diarrhoea, respiratory problems and increased mortality. At autopsy enlarged lymph nodes with depletion of lymphocytes are commonly found. Since 1991 PMWS has spread all over the world and was first described among Swedish pigs in 2003. Although PCV2 is widespread, only some pigs develop PCV2-related diseases. Why this is and what other factors that are required in order for the disease to develop is yet unknown. The main theories involve other infections, for example PRRS, and management issues but also Genetic differences between pigs and/or virus strains have been suggested.