The objectives of this study was to examine the prevalence of hypertrophic cardiomyopathy in a family of British Shorthaircats to determine the mode of inheritance and to investigate if the disease was associated with a mutation in myosin binding proteinC (MyBPC3). The family comprised 28 cats, seven male and 21 females. The cats underwent a physical examination, including cardiac auscultation, and an ultrasound examination. Blood was collected for DNA- analysis. The blodsamples were sent in a buffer solution to Kathryn Meurs, Washington State University, USA for analysis, where the genes coding for MyBPC, Troponin I and T were characterized using microsequencing technique. Out of the 28 cats, 8 were diagnosed with HCM, 2 were diagnosed with congenital heart disease but had no evidence of HCM.

So far, only limited research has been carried out on viruses infecting raspberry, even though the diseases that these viruses cause result in economical losses for raspberry growers. Raspberry ringspot virus (RpRSV) belongs to the family Comoviridae and the genus Nepovirus. Nepoviruses are characterized by their icosahedral virus particles and bipartite genome of single-stranded (+) RNA (RNA-1 and RNA-2). These viruses are transmitted mainly by nematodes of the genus Longidorus, which feed on the roots of plants. RpRSV causes disease in raspberry, grapevine, strawberry and many other plants.

Genetic defects are caused by mutations in major genes where the gene?s protein product has a large impact on the physiology of the animal. The synthesis of the protein can be altered by a change in the nucleotide sequence, which can lead to malformation and in many cases death.One of the main reasons of increase in many genetic defects is the use of few bulls in breeding programmes, causing a reduction of the genetic variation. Genetic defects cause suffering for the animal and influences the production by, for example, increased costs due to misscarriages, lost milk production and expenditure for medical treatment. Bovine Leukocyte Adhesion Deficiency (BLAD) and Complex Vertebral Malformation (CVM) are two genetic defects that were widespread before the causative mutation was discovered.

I naturen har färgen på hönans (Gallus) fjädrar en betydande roll för dess överlevnad och reproduktion. I början av domesticeringen handlade det om att selektera ut individer för produktion, religiösa seder och tuppfäktning. De senaste århundradena har även det estetiska utseendet fått en större betydelse i vårt samhälle, både när det gäller färg och mönster på hönans fjäderdräkt men även när det gäller färgen på dess äggskal. Man har genom studier visat att pigmentet melanin har en betydande roll för fjädrarnas färg och mönster. Genom forskning har man kunnat identifiera olika gener som är inblandade vid uttrycket av fjäderdräktens färg och mönster och några av dessa loci är E, C och I.

The research in the field of biotechnology is rapidly developing all over the world. Modern biotechnology offers unique opportunities, simultaneously as it gives rise to a number of ethical issues. Preimplantation genetic diagnosis (PGD), PGD/HLA (Human Leucocyte Antigen) and germline gene therapy (GLGT) are controversial techniques. PGD gives a possibility to identify a genetic disease prior to the embryo?s implantation in the uterus.

2011 fick den svenska skolan nya styrdokument att förhålla sig till och arbeta efter. Nu finns begrepp som sexualitet, relationer, kön, identitet, jämställdhet och normer inskrivet i de nya ämnesplanerna för gymnasieskolan. Förändringen innebär att ansvaret för undervisningen i sexualitet och relationer, tidigare sex- och samlevnadsundervisningen, inkluderas i flera ämnen och därmed vilar också ett ansvar på lärarna i berörda ämnen. Rektorn har dock, precis som tidigare, det övergripande ansvaret för att styrdokumenten följs. I denna empiriska studie har vi undersökt hur lärare på gymnasienivå tolkar att de ska undervisa i sexualitet och relationer inom ramen för ämnet samhällskunskap.

Roseroot (R. rosea L.) has gained more attention the last years, mainly because of its phy-topharmacologic properties. Even though many reports in roseroot have been published, only a few articles are dealt with the genetic diversity. The Nordic Genetic Resource Center has collected Roseroot material from Sweden, Greenland and Faroe Islands under different expeditions. The samples were analysed to study the genetic diversity study.

The dairy cow?s ability to resume estrus after calving and to conceive is affected by their metabolic status after calving. For high yielding cows there is a high risk that the feed intake will not be sufficient to cope with the increased energy demands after calving, and the cow will end up in a state of negative energy balance. Energy balance can be measured in various ways, for example by body condition score or by plasma concentration of several metabolic hormones and metabolites. After calving, endocrine pathways stimulate tissue mobilization; insulin signaling is blocked, the concentration of insulin-like growth factor-1(IGF-1) and leptin decreases, and the concentration of growth hormone (GH) increases.

Many pedigree dogs are suffering from inherited diseases or personality disorders caused by selective breeding. The Swedish lapphund is a breed that has been suffering from some loss of genetic variation due to the heavy use of only a few males. Concerns have arisen and crossbreeding has been discussed as a way to manage gene loss. Four breeds has been taken into consideration for this purpose; schipperke, finish lapphund, Norwegian buhund and Norwegian elkhound, black. These breeds has been tested theoretical by a comparison of mentality and health.

Today in Sweden, apples are mostly cultivated for direct consumption, i.e. dessert apples. Apple breeding aims at developing cultivars with new and improved qualities in order to meet the demands of different target groups and to increase the interest in apples on the market. Different target groups have different views on the qualities of an apple. The consumer, for instance, wants an apple that is tasty and beautiful, while the grower, in addition, wants an apple cultivar that is healthy, has good winter hardiness and a predictable, annual productivity.

This study has focused on testing the following two hypotheses:? Pest resistant plants have higher levels and/or several different kinds of secondary metabolites. ? Induced defensive systems in resistant plants are activated more rapidly than those of susceptible plants. As a background for the test of the hypotheses a short literature study was performed concerning plant defensive mechanisms in Arabidopsis thaliana.

Introduction The genetic skin disease epidermolytic ichtyosis is caused by mutations in either keratin gene 1 or 10 and leads to blisters and hyperkeratosis of the epidermis. At cellular level the disease is seen as aggregates in the keratin filaments. Since medicines are hard to investigate and produce mainly due to lack of reproducible model systems, there is no good treatment available for this disease today. In this article we describe how an in vitro model consisting of cells from a stable cell line transfected with expression plasmids to mimic patient cells, may be a possible alternative for screening compounds for therapies. The first step was to generate an expression plasmid required to complete the in vitro model.

The genus Campylobacter is globally recognised as the leading bacterial cause of human foodborne gastroenteritis. Every year around 8000 Swedes are infected by Campylobacter. Most people are infected by thermotolerant Campylobacter species, commonly C. jejuni and C. coli.

Syftet med denna studie är att undersöka och belysa upplevelser av etnisk diskriminering bland andra generationens invandrare med akademisk bakgrund, vilka genom namnbyte från ett utländskt till ett mer svenskliknande namn, tror sig öka sina möjligheter på arbetsmarkna-den. Frågorna jag har valt för att uppnå syftet är: Hur har den tankeprocess kring etnisk dis-kriminering på arbetsmarknaden sett ut som föranlett ett namnbyte från ett utländskt till ett mer svenskliknande? Vilka föreställningar om etnisk diskriminering på arbetsmarknaden har de som bytt namn? Har namnbytet från ett utländskt till ett mer svenskliknande namn infriat individens förväntningar på arbetsmarknaden? Metoden jag använder för att illustrera syftet är av en kvalitativ ansats där det empiriska materialet består av fyra intervjuer med andra gene-rationens invandrare med akademisk bakgrund. I studiens teoretiska del har jag vetenskaplig litteratur som grund för att vidare kunna i resultatanalysen diskutera de olika faktorer som be-lyser problemställningen. Min slutsats av denna studie är att föreställningar om den andra gruppen, har hämmat, både den större gruppen och den lilla individen.

Over time, species colonize new areas naturally or through humans. The colonizers areoften few and founded populations represent only a fraction of the genetic diversityexisting in the original population. If the established population becomes isolated afterthe colonization event genetic diversity will remain low and if the population, in addition,remains small in size for an extended period this will lead to increased inbreeding andpossibly inbreeding depression. Metrioptera roeselii is a common species with awidespread distribution in continental Europe. During the last century, it has expanded tothe Scandinavian Peninsula which is separated from continental Europe by the Baltic Sea.My aim was to test the hypothesis that individuals in isolated populations in Scandinaviaincluding Denmark and the Baltic Sea islands are smaller than individuals in thecontinuous part of its distribution due to low genetic diversity and lacking incoming geneflow.