During the last years, producers and consumers have become increasingly aware of food safety. Foodborne illness and foodborne injury are in best case unpleasant but they can also be Fatal. HACCP (Hazard Analysis Critical Control Point) is a preventative food safety system which is aimed to guarantee production of safe food free from pathogens, foreign materials and substances with potential to cause adverse health effect. In order to succeed in developing, installing, monitoring and verifying a HACCP system, there is a mix of hurdles for the company to overcome. While larger food companies meet a difficult challenge, small and medium size enterprises often feel that the hurdles are almost impossible to manage.

The danger and vulnerability associated with a preterm birth seem to be closely correlated with a dysfunction of the fetal hypothalamic-pituitary-adrenal (HPA) axis, whose maturation in the foal is without a doubt as delicate as it is important. Not only is this endocrine cascade vital for the foal in order to cope with neonatal stress, it also appears to be fundamental for the final fetal intrauterine maturation, as well as for the onset of foaling. Equine gestation exhibits some rather unique features, indicating a somewhat different significance of the endocrine changes associated with HPA maturation, compared to many other species. This hormonal cascade is rapid and confined to a narrow time during late gestation in the horse, and the risk of the foal completely missing it therefore becomes prominent. Induced parturition in the mare may be operated through uterotonic agents, which occasionally bring about premature foals. Desirable seems the ability to initiate equine labour while simultaneously enhancing fetal HPA maturation, as in humans and ruminants through perinatal glucocorticoid administration. However, similar treatment in the horse has resulted in various, sometimes Fatal, outcomes. In the light of the distinctive features of equine gestation, difficulties are encountered following such administration of glucocorticoids and ACTH.

Virulent strains of Staphylococcus hyicus produce exfoliative toxins and cause a potentially Fatal skin disease in piglets known as exudative epidermitis. Vaccines and antimicrobials are used to control the disease. Antimicrobial resistance and the prevalence of several different toxin genes and toxigenic strains make it problematic. The aim of this literature study was to identify potential differences between countries and between healthy and diseased pigs regarding antimicrobial resistance and toxin-producing strains. Great differences could influence vaccine production, treatment strategies and surveillance programs.

The word crisis is often used in everyday language, but according to political theory it actually refers to a crisis situation within a country where national interests suddenly are at stake demanding that important and complex decisions must be made within certain time constraints. These decisions can in turn lead up to most Fatal consequences. USA, being one of the world's superpowers is most certainly involved in crisis situations directly or indirectly, frequently or more seldom. Amounts of people get suddenly involved and even more people can be drawn in by the decisions that are made thereby. Research has shown that the character of a leader affects decision-making.

Incompatibility between donors and recipients can cause Fatal hemolytic transfusion reactions (HTR), kidney damage and death and immunization of the recipient. Antigens on the surface of erythrocytes in the ABO blood group system and regular natural antibodies against these in the patient?s plasma must be considered. An individual always has a corresponding antibody of IgM in their plasma. Irregular antibodies acquired by transfusion or pregnancy and active in body temperature also cause the HTR incompatibility.

Francisella tularensis, the causative agent of the zoonotic disease tularaemia, is highly contagious and potentially Fatal for a wide range of wildlife species of the northern hemisphere, also humans. Although recognized as a pathogen for over 100 years, much still remains to be elucidated concerning the ecology and transmission of the bacterium, hence this literature overview aims at compiling data regarding the aquatic association and the role of mosquitoes in transmission of Francisella tularensis subspecies holartica, the sole subspecies in Sweden. While a linkage between the bacterium and natural waters stands beyond dispute, there is no consensus in the literature concerning its potential as a reservoir. However, two prevailing theories can be distinguished; one proposes the water association being mammaldependent and thus merely the result of contamination from semi-aquatic mammals living in close vicinity to the water source. The other, quite contrary, suggests mammal-independence and hence that water, possibly in association with protozoa, serves as an environmental reservoir for the bacterium.

Background: In previous studies on the subject hope it has been revealed that hope is an important condition for the experience of health, quality of life and well-being. In the literature hope is described as a great support in life that is vital for a person's life and for how the person manages to become afflicted with a Fatal disease. Within palliative care the 6S: s is a person-centered model for care that is directed towards the promotion of patient´s participation, relief from suffering and enablement of well-being and support of the patient and his or her family members. Aim: To describe how patients find hope in their situation in palliative care, and to examine whether there is an interaction between the different dimensions of 6 S: s model and with patients' experiences of hope. Methods: This degree project is literature study.

Nematoden Toxocara canis är ett av de vanligaste endoparasitproblemen hos unga valpar, både i Sverige och i övriga europeiska länder. Vid kraftiga infektioner kan T. canis orsaka utmärgling hos valpar och i sällsynta fall obstipation med Fatal utgång. Nematoden kan även orsaka skada hos människan då T. canis larver penetrerar olika organ.

Sedan oktober 2011 sköter Sjukvårdens Larmcentral, SvLC, utalarmeringen av akuta sjukdomsfall som inkommer vid 112-samtal. Samtidigt infördes ett nytt medicinskt beslutsstöd för de sjuksköterskor som tar emot de akuta samtalen. Då orsaken till buksmärta är komplext och svårt att identifiera hos patienterna valdes just detta tillstånd för granskning.Syfte: Att undersöka om det medicinska beslutsstödet för sjuksköterskorna på SvLC i Uppsala län är en tillförlitlig hjälp i identifieringen av patienter med akuta buksmärtor, samt att undersöka om det fanns ålder-eller könsskillnader.Metod: En empirisk kvantitativ studie med en retrospektiv journalgranskning. Sammanlagt 151 patienter som ringt ambulans på grund av buksmärta och som av larmcentralen prioriterats som livshotande (prioritet 1) eller brådskande (prioritet 2) har granskats.Resultat: SvLC´s initiala bedömningar stämde väl överens med de prehospitala bedömningar sjuksköterskan i ambulans gjorde. Hos prio1-gruppen hade 48 % diagnostiserats buksmärta UNS, det vill säga buksmärta utan närmare specifikation, och hos prio 2-gruppen var det 40 % som fått samma diagnos.

Safety in the construction industry has become a question of top priority in recent years. Despite a massive investment of time, money and knowledge, the occur-rence of Fatal accidents in Sweden alone is around one a month.The purpose of this study is therefore to improve the safety on the construction site. By an examination of the role of the safety agents and their cooperation with the construction workers and supervisors as well as examine how safety agents can improve safety on the construction site, which is the goal of the study.Four questions were formulated based on the purpose and the goal of the study.The methods used to answer the questions were a questionnaire survey, multiple interviews, a literature review and a document analysis.The report describes the safety agent?s role as a complex one with many different tasks. The role of the safety agents is regulated in the health and safety law, but it can sometimes be difficult to interpret and the agents can therefore interpret their role differently.

In the spring of 2006 we had our first outbreak of avian influenza of highly pathogenic H5N1 (HPAI) among wild birds in Sweden. This disease have impact on poultry industries world wide. Sporadically the virus infects other species than birds and we now know it can even cause Fatal infection of humans. There are not yet any confirmed cases of transmission of the disease between humans though a suspected case in an Indonesian family is under investigation. If a mutation occurs that changes the pathogenicity and host affinity to humans we are at a risk of a new pandemia, perhaps like the Spanish flu in 1918-1920.

Single vehicle accidents are one of the most common types of accidents that occur on the Swedish road network. Depending on the design of the road, the presence of a crash barrier and embankment on the roadside, the outcome of a roadside collision can lead to serious injuries and even deaths.The aim of this project is to investigate the possibility of improving road safety by designing the optimal roadside area based on the results of a life cycle cost analysis (LCC).The questions that have been answered during the duration of this project are:1) Describe the current technical solutions for roadside area design and the various barrier types used in Sweden.2) Complete an existing mathematical model that has been developed by Hawzheen Karim, for calculating life-cycle costs for various roadside areas.3) Calculate and compare the life cycle costs for the side area with a barrier and without a barrier.By performing an analysis of the documentation on the current guidelines and rules for shaping the roadside, was it possible to describe the current technical solutions for the formation the roadside as well as the current roadside barriers in use today. A mathematical model for calculating the life cycle costs of different barrier types had already been developed by Hawzheen Karim. This model was supplemented so that it could calculate life-cycle costs of the roadside region with and without a barrier. After the model was completed, an analysis was performed to obtain life-cycle costs of a roadside with and without a barrier.The result showed that there is a clear relationship between the slope inclination, fill height, and the rate at which the costs rise.

Background:  Heart failure is a multidimensional phenomenon with high mortality. Heart failure is treated with angiotensin converting enzyme (ACE) - inhibitors or angiotensin receptor blockers (ARBs) that counteract neurohormonal stimuli that occur in heart failure, as well as providing vessel dilatation, which reduces symptoms and the need for hospitalization and increases survival. Despite this, only about 50% of heart failure patients survive 6 years after diagnosis with drug therapy, and as heart failure is increasing globally, due to improved care and treatment and increasing life expectancy of the population, there is a great need for new drugs such as LCZ696 that acts by dual inhibition of the renin - angiotensin - aldosterone system and neprilysin inhibition.Objective: The aim of this literature study was to evaluate the efficacy of current treatment and possible future treatments on mortality and morbidity in heart failure patients.Results: The examined articles show that treatment with ACE inhibitors in patients with symptomatic heart failure reduces the risk of total mortality by 16% over 3.5 years, reduces all-cause mortality or hospitalization due to heart failure with NNT (number needed to treat) = 10.4 over 3.5 years and increases median survival by 9.2 months over 12.1 years in patients with asymptomatic heart failure. Treatments with high-dose ACE inhibitors reduce mortality and hospitalization because of cardiovascular causes and hospitalizations from any cause by NNT = 30 over 3 years. Beta-blockers reduce sudden death and total mortality and cardiac death or non - Fatal myocardial infarction with NNT = 38 and NNT = 23, respectively, over 12 months.

Water is vital for all life on earth. But it can also be dangerous, even Fatal, if it is polluted water. 60 percent of child mortality can directly be deduced to dirty water. Not only developing countries are affected, even in the western world epidemics are breaking out by partake or bathing in dirty/polluted water.MIP, Molecularly Imprinted Polymers, is a biosensor technology that can provide faster and more reliable response than the current methods of water analysis. It is also cheaper and due to that more samples can be taken and analyzed.

Background: Approximately one in three Swedish people will receive a cancer diagnosis. Cancer primarily affects the elderly but also young people suffer. Young people are in a period of life that could put a strain of the ordinary when they are faced with choices and new challenges. The basic sense of security in everyday life is not so obvious and many suffer from, for example, stress and the feeling of being inadequate in relation to the requirements. It is relevant that the nurses can put themselves into what it is like to be young and afflicted with cancer, with the pressures of life itself and what the disease represents.