Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

Problem definition and purpose: A debated question in journalism today is if the mass media have the power to affect norms and values in the society. There are therefore many who believe that the media must works for democratic and equitable news coverage. Studies have shown that there are still many differences in how women and men are being portrayed in the Swedish media, even if Sweden is one of the most equal countries in the world. This inequality may affect the democracy and equality in the society negative.Previous studies have mainly been using gender as the only explanatory factor to explain the difference of coverage between men and women in the news content. The purpose of this study will therefore not only be to compare the coverage of the Green Partys two spokespersons, Åsa Romson and Gustav Fridolin, from a gender perspective but also to take in count other factors that could contribute to differences in the news coverage.Method and material: To find an answer to the purpose of this thesis a quantitative content analysis have been done on a total of 238 news articles in which Åsa Romson and/or Gustav Fridolin occur.Main results: The results of the content analysis show that Gustav Fridolin occurs more frequently in the news than Romson does, and that the articles he appears in is lager than the articles in which Romson appears.

This thesis describes a tool for data mining used to optimize ambulance preparedness. The goal with the tool was that it should be able to retract the information necessary to be able to analyze and calibrate the preparedness model used in the software ResQMap. ResQMap is used by SOS Alarm, who are responsible for the Swedish emergency number 112, as a decision support tool for ambulance operators. It is developed by Carmenta AB, who are the supervisors of the thesis work. Also, a minor study of the preparedness models variables has been performed in order to be able to evaluate the function of the tool.

Comfort analyses regarding human induced vibrationsIt is not too common among civil engineers in Sweden to perform comfort analyses considering the vibrations caused by human activities. In addition, the Swedish standards lack requirements to be used for comfort analyses in design of floor-systems. The demand for large spans in combination with slender slabs, is today a reason to investigate the floor-system constructions, in order to prevent disturbing vibrations and oscillations.The purpose of this thesis is to create a guide for how a comfort analysis, considering vibrations, should be implemented. Göran Svedenbjörk who is an expert in structural dynamics has been interviewed where he presents his latest project Värtaterminalen and answers some questions about vibrations due to human activities.Floor-systems, consisting of concrete slabs supported by steel or concrete beams, have been investigated with simulations in the finite element program Abaqus. In the simulations, the influence of various factors on the natural frequency of floor-systems and the acceleration level caused by dynamic loads, is studied.

The Swedish Cellulosa Companiy, SCA, has today 280 000 ha planted with lodgepole pine (Pinus contorta var. latifolia) (?C?) which is equivalent to 14 % of its total forest area. Exotic lodgepole pine has in previous experimental stands shown a superior growth than the native Scots pine (Pinus sylvestris L.) (?S?).But also the comparison could be questioned because stand histories were was unknown and also differences in age between C and S existed.

Background: Investors have several options to choose from when the goal is to achieve the highest yield at the lowest cost and risk. Stocks are a common investment options, but is also associated with risks. Portfolios are usually constructed with several different assets to reduce the unsystematic risk of investment. Funds are similar to composite stock portfolios, the big difference is that they dealt with in their entirety and investors may not affect the fund's content. The problem remains that whether you choose stocks or mutual funds there is still uncertainty as to how the future will unfold.

Like many small-time companies there is a need to improve the flow of materials at HSP-Gripen AB. The company develops and manufactures hydraulic-powered grapples for the machine- and forest industry. By mapping the material flow in the current production and gathering necessary data, suggestions on how different parts of the production could be controlled is presented in this dissertation. This has been achieved by the study of relevant scientific literature. The suggested ways of controlling the production consist of 2-bin systems, hybrid material flow system as well as a cyclic product-planning.

Historically transformers with system earth equipment have been modeled as open circuits in zero sequence. This approximation has been satisfying, but lately it has been discovered that equipment on one side of the transformer have responded to faults that occurred at the other side. Most of these problems took place when the majority of the system on the secondary side of the transformer contained cables. These findings have led to questioning whether or not the former model of the transformer in zero sequence is correct. This report investigates if it is necessary to represent the transformer in zero sequence in another way than it is usually done today.

The main purpose of this thesis is to analyze why or why not Swedish municipalities implement the gender equality policy ? ?right to work fulltime?. In order to understand this institutional change, the analysis is based on a theoretical framework consisting of two fields: political representation and feminist institutionalism. The study is divided into two empirical inquiries. The first part is based on a quantitative survey that describes the casual relationship between two independent variables; women´s political representation and party ideology, and the dependent variable; political decision about ?right to work fulltime?.

Today we can create digital 3D models which can be realised almost instantly through production methods such as 3D printing and computer controlled milling.What if this same technology could be applied to the development and construction of terrain parks?With snow as the material tools could be developed using similar principles to design and sculpt the surface, only on a larger scale.How would terrain park designers adapt their process to use this new technology? In this Industrial design thesis I explore how the ideas of the terrain park designer can be expressed through such a system with focus on the designers knowledge and skill without the need to learn complicated 3D programs.Sketch, create, ride. .

Many dairy farms doesn?t keep their bull calves and cross cow calves, they sell them to breeders instead of raising them their self. It should be possible for the dairy farmers to do it them self?s. There is also a possibility to bread one calf from the cross heifers. The purpose of the investigation was to see if there is any economic possibility to breed beef cattle. I have used the same sample farm trough the hole study, because it would be easier to fallow the study.

AbstractTitle:HelpTube: A Study on the Motivation behind Crowdsourcing with STD & Motivation Functions for Volunteer Work as Explanatory models. Level: Bachelor Thesis in Business Administration; C-level. Authors: Honey H. Shahraki & Linnea M. Pira Supervisor: Jonas Kågström Date: 2013- June Background: In recent years the trend and usage of social networking has increased significantly amongst individuals as well as businesses.

Around the world, forests are generally being fragmented and as plant populations decline in both sizeand number of individuals, the genetic variation will also decrease whitch in the end leads to totalextinction of the plant. In this paper, I wanted to investigate what specific species of trees and shrubsyou usually find in the edge and core habitats in some of the forests in the Baltic Sea region. I alsowanted to identify the edge effects and their sources and finally compare the results between thedifferent regions.The data sources used are derived from the ongoining research project Landscape structures, patterns ofbiodiversity and conservation strategies in the Baltic Sea region by Kari Lehtilä, Patrik Dinnétz ochTiina Vinter who have made a record of all herbaceous plant species in four randomly chosen forestregions situated around the Baltic Sea: Estonia, Skåne, Södermanland and Germany. I made statisticalanalyses, using the computer program R, concerning the distribution of species in the edge habitats ofthe forests as well as in the core habitats. I performed generalized linear models and then variationanalyses with the factors light and biomass in order to investigate wether edge effects might appear dueto these factors.

This thesis project focuses on the need for better tools for analyzing competition for forest fuels in Sweden, in particular how policy measures may influence the market and involved actors in different regions of Sweden. Raw materials from the forest have for long constituted important inputs in the Swedish forest industry. Today some of these raw materials are increasingly used as inputs also in bioenergy production, largely driven by bioenergy promoting policies, and there are signs of increased competition for forest fuels which may have various and uncertain effects on the industries in question. The thesis project explores the possibilities to adapt previously used forest sector equilibrium models into a new model suitable for analysis of Swedish forest fuel markets, called the Swedish Forest Sector Trade Model (SFSTM). The approach takes into account regional differences in supply and demand for 23 types of products produced and/or used by eight types of producers, plus consumers, in five different regions (four Swedish and one international).

The purpose of the present study was to investigate the cow-level association between acute hoof lesions and the somatic milk cell count in dairy cattle. Cows from three loose-housed Swedish dairy herds were enrolled in the study if they had an acute hoof lesion treated by a veterinarian or professional hoof trimmer during the preceding year, according to farmer records. Studied lesions were sole ulcer, dermatitis, interdigital necrobacillosis and hoof abscess, in each case causing lameness. For each hoof-diseased cow, 0 to 3 healthy cows were included, matched with respect to herd, breed, parity and lactation stage. Cell counts were obtained from monthly test recordings from one month before to three months after the hoof-lesion diagnosis, and log-transformed.