The process of drug discovery is very slow and expensive. There is a need for reliable in silico methods; however the performance of these methods differs.This work presents a targeted study on how the drug discovery methods used in OpenEye?s tools ROCS, EON and FRED perform on targets with small ligands. It was examined if 12 compounds (markers) somewhat similar to AMP could be detected by ROCS in a random data set comprised of 1000 compounds. It was also examined if EON could find any electrostatic similarities between the queries and the markers.

Läkemedelshanteringen är ett av sjuksköterskans ansvarsområden inom hälso- och sjukvården. Utifrån kunskap och lagar skall den bedrivas på ett patientsäkert sätt men trots det sker läkemedelshanteringsfel vilket innebär risker i patientsäkerheten.Syftet med studien var att beskriva faktorer som påverkar säkerheten i samband med sjuksköterskans läkemedelshantering. Studien genomfördes som en litteraturstudie. Resultatet visade att vanliga läkemedelshanteringsfel är utebliven dos, fel administreringstid, fel dos, fel administreringssätt, fel läkemedel och läkemedel till fel patient. Faktorer som påverkar sjuksköterskans läkemedelshantering är felaktiga och dåligt skrivna läkemedelsordinationer, distraktion under läkemedelshanteringen, bristande rutiner samt införande av ny teknologi.

Tomato production is a common and important agricultural activity in Nicaragua. During the last decades tomato producers have suffered great yield losses due to begomoviruses (family Geminiviridae). The genome of begomoviruses generally consists of two circular ssDNA components, DNA-A and DNA-B. Tomato yellow leaf curl virus (TYLCV) is an example of a begomovirus with only one component. An approach to manage the virus epidemics has been to breed a cultivar with begomovirus resistance genes, which have been transferred from wild tomato.

Calesco Foil AB is a manufacturer of thin flexible circuits for heating or electric conduction.The plant is located in Kolbäck, Sweden.One of the company?s products, the conducting polymer pasta is in present situationunpredictable. Unpredictable in the way that the same type of heater shows differentresistance, depending on which time they have been produced. The desired repetitivelyprocess is almost non-existing.The aim of this master thesis is to primary identify those parameters that effects theresistance, observe and if possible to perform tests on them. The results from this analysisstand as base for recommendations to achieve a repetitive and standardized printing process.The results and the observations from the tests indicate that a repetitive process is possible toachieve.

Gender in Administrative Court of Appeal - A discourse analysis of verdicts concerning compulsory drug treatmentThe purpose of this study was to examine gender discourses that could be identified inverdicts concerning compulsory drug treatment. A discourse analysis was conducted of 46verdicts from an administrative court of appeal, located in central Sweden. The main findingsof the study was that the descriptions of women, more often than men, are based on factorsother than their addiction, such as appearance and social environment. Men are in all casesdescribed by their addiction and on their own behavior. Women are presented as they riskvulnerability, while men are presented already suffer from vulnerability.

Virulent strains of Staphylococcus hyicus produce exfoliative toxins and cause a potentially fatal skin disease in piglets known as exudative epidermitis. Vaccines and antimicrobials are used to control the disease. Antimicrobial resistance and the prevalence of several different toxin genes and toxigenic strains make it problematic. The aim of this literature study was to identify potential differences between countries and between healthy and diseased pigs regarding antimicrobial resistance and toxin-producing strains. Great differences could influence vaccine production, treatment strategies and surveillance programs.

The increased frequency of reported Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is of great concern to small animal healthcare due to limited options of antimicrobial therapy. The aim of this literature study is to investigate 1) characteristics and classification of S. pseudintermedius, 2) resistance mechanisms and emergence of MRSP, 3) risk factors for selection of MRSP, and 4) clonal distribution around the world. S. pseudintermedius is a skin and mucosal commensal in healthy dogs and cats, but can cause infections, including pyoderma. Beta-lactam antibiotics inhibit bacterial growth by binding to the penicillin binding protein (PBP), a vital enzyme in the synthesis of the bacterial cell wall.

This master thesis has been carried out on behalf of Stoneridge Electronics AB and is an investigation ofhow intelligent switches can replace the traditionally used direct controlled switches. The concept ofintelligent switches is that the switches contain electronic identification components which, by connectingthem to a network, give the same function independent of the location of the switch. This infers anincreased flexibility and configurability which can be a great advantage in development, production andcustomization in the commercial vehicle industry. Especially in the current situation when commercialvehicle manufacturers provides more and more functions and dashboard configurations.LIN (Local Interconnect Network) is a network protocol introduced in 1999. It is a simpler and lower costcomplement to CAN (Controller Area Network) and is adapted for applications where the demands forbandwidth are lower, for example reading sensors and switchers.

Aims: To examine how patients with experience of being involuntarily discharged from medication-assisted treatment with methadone or buprenorphine have coped with the consequences following the discharge. The study also aim to examine how the patients cope with the stigma related to their abuse of heroin and how they manage to cope with the rules regarding themedication-assisted treatment. Method: Three patients with experience of involuntary discharge from medication-assisted treatment have been interviewed. All were heroin abusing men living in Stockholm. The interviewees were recruited through the Swedish Drug Users Union and through a shelter for homeless people with drug problems.

Obese horses with insulin resistance are often also afflicted with laminitis. Horses with these symptoms are given the diagnosis equine metabolic syndrome (EMS). Signs of insulin resistance are excessive accumulation of adipose tissue on the neck, around the withers and on the dorsal area of the hindquarters. Insulin resistance means that the function of insulin is defective and does not stimulate glucose uptake by the cells in the body in the correct way. This will result in an increased insulin release.

Nearly nine percent of the population in Sweden are 75 years or older. Still they consume more than a quarter of all medicines. This increased use, is specially noticeable in nursing home residents, where the elderly is using a average of 8-10 preparations per day. According to the National Board of Health and Welfare in Sweden, the number of drugs and specially psychotropic drugs, has proved to be a risk factor for drug-related problems among the elderly, such as drug interaction and side effects. Routines for regular and systematic follow-up of drug prescription and utilisation reviews were not extensively implemented.

Då jag som receptarie kommer att ha ett ansvar när jag expedierar läkemedel ville jag lära mig mer om interaktioner (samspelet) mellan olika läkemedel samt interaktioner mellan traditionellt växtbaserade läkemedel (TVBL) och vanliga läkemedel. Min avgränsning gällande TVBL kom att bli interaktioner mellan johannesört och vanliga läkemedel och detta därför att johannesört är det växtbaserade läkemedel som interagerar mest och kan ställa till det ordentligt vid fel kombinationer. Som receptarie har jag ett ansvar gentemot apotekskunden och därför kände jag att jag ville fördjupa mig i interaktionsproblematiken. Den farmaceutiska kompetensen innefattar i hög grad kunskapen om läkemedelsinteraktioner. Farmaceuter arbetar sida vid sida med sjukvården och har ofta kontakt med förskrivande läkare och då kan det vara bra att rent professionellt kunna hur specifika interaktioner yttrar sig.

The purpose of this essay was to investigate the opinions of young people, age 14-16, at a school in a middle-sized city in Sweden, concerning narcotics. The questions we asked ourselves were;-What are young peoples' ideas of narcotics?-What do young people imagine when they think of a drug addict?-What reasons do young people give to start using narcotics?-What gender-related opinions do young people have regarding drug abuse?-What do young people think about legalization of narcotics?For this purpose we interviewed six girls and six boys. We interviewed them one at a time, for about an hour each. We used a qualitative method for the interviews.The young people in our study described narcotics as "dangerous".

Oilseed rape crops are an important in southern Sweden because of the high intensity of wheat growing. Pollen beetles are the most important pest in oilseed rape and causes often economic losses. Therefore it?s of great importance that we can control the population density, e g by using insecticides if necessary, to avoid mayor yield losses. In year 2000 pollen beetles were numerous in the province of Östergötland. The farmers sprayed with insecticides several times, but with low effects on the beetles. Field trials and laboratory experiments showed that pollen beetles had developed resistance against pyrethroids.

The European Union has created a common plan regarding narcotics use and abuse within the European member states. The aim here is to reduce the supply and demand for drugs among the citizens of the Union. However, the opinions on how to achieve these goals greatly differ among member states. The range of attitudes varies from the strictly restrictive attitudes of countries such as Sweden, to the complete decriminalization of personal possession of all narcotic substances in Portugal. The purpose of this paper is therefore to study the underlying attitudes and approaches that these two countries have, and hopefully to give some light to how come there is this big difference in legal frameworks regarding a rather delicate political question.