Itraconazole is a third generation azol, a fungicide which acts by inhibiting ergerosterol synthesis in the fungal cell membrane, and thereby disturbing fungal regeneration. It has proven to be less toxic, to have a broader spectrum of activity and to be more potent than its predecessor ketoconazole. Itraconazole is only available in therapheutics approved for human use. Pharmacokinetic studies has been performed in humans, dogs, cats and laboratory animals. Although itraconazole has been used tentatively with good effect against fungal infections in horses, no pharmacokinetic studies have yet been done.

I detta examensarbete har en tillförlitlighetsmetod tagits fram som väger samman kostnadspåverkande faktorer för investeringar och underhåll i eldistributionssystem med kostnader förknippade med avbrott. Syftet med metoden är att möjliggöra för nätplanerare och projektörer att jämföra olika investeringsalternativ för att kunna kostnadseffektivisera investeringarna i eldistributionssystem. Med tillförlitlighetsanalys kan den förväntade avbrottstiden i systemets uttagspunkter beräknas. Kopplas en kostnad till den förväntade avbrottstiden i uttagspunkterna kan den förväntade avbrottskostnaden för distributionssystemet beräknas. Syftet med simuleringarna har varit att undersöka om det går att minimera den totala kostnaden, investeringskostnader samt förväntade avbrottskostnad, genom slumpvisa investeringar i systemets ledningssektioner. Simuleringarna har genomförts på ett fiktivt mindre system.

X-rays are a potential risk for animal health care personnel. The present study will examine the risks for scattered radiation to the personnel, if no lead gloves are used when holding an animal during the x-ray examination. Furthermore, how the impact of the exposure values and body parts examined, affect the scattered dose to the hands of the holder. Also, the distance between the animal and the hand that holds it was evaluated to see the impact on scattered radiation exposure. Tested by a survey, to animal health care students, the frequency of the usage of lead gloves in Swedish animal hospitals was studied. According to the results from the analysis, animal health care personnel don't need to use lead gloves every time they hold an animal or a cassette during x-ray examinations.

1. Reaction on burial depth and nitrogen availability and placement in competition with a crop In this trial it was investigated how couch grass (Elymus repens) changes its ability to compete in stands of wheat and barley with different burial depth and different amounts and placement of nitrogen. More knowledge in this area can be valuable in the attempt to decrease the use of herbicides and still keep the weeds under control. The trial was carried out in the summer of 2004 as an outdoor pot experiment. The pots contained 15 litres of soil with a surface of 0,06 m2.

Internet is used today as a traditional medium for information exchange and social interaction. One of these is virtual meeting places where people meet and exchange information, socialize and exchange knowledge with each other. The group has chosen to examine the factors affecting the use of web forums, one of the virtual meeting places that exist on the Internet today. And look at how people use the web forum today in the current situation and how to design a web forum.A survey was conducted to find out how people look at web forums today, 80 people participated, and they got to talk about what they think about different web forums regarding how and why the use these them. Guidelines on how a web forum should be designed were also developed.

ABSTRACTMultiple sclerosis (MS) is the leading cause of adult disability inSweden. Hematopoietic stem cell transplantation (HSCT) can be used as a treatment option for patients with MS where the disease has an aggressive course. The treatment is preceded by high-dose chemotherapy which lowers the patient's immune system. It is therefore of interest to study infectious complications associated with HSCT in this patient.Aim: The purpose of this study was to identify infection problems in this population associated with HSCT, and to study differences in infectious complications between this group and patients diagnosed with lymphoma who have undergone the same treatment.Method: The study was a retrospective descriptive study with quantitative data. A medical record review was conducted.

Forest enterprises have always searched for ways to improve efficiency. For the past few years there has been an emphasis on stock-keeping levels. Increased demand for fresh round timber and the need to decrease the amount of tied-up capital has made the forest industry reduce its inventory levels. This has brought on a higher demand on the timber supply from the forest management districts concerning both delivery in time and assortment output. As a result, the flow of timber has fluctuated a lot with serious consequence for the timber supply during 1994.

Today there are no analgesic drugs approved to be used in goats. Drugs approved for use in other species are consequently being used without knowing the pharmacokinetics of these drugs in goats. The purpose of this study was to investigate the pharmacokinetics of the opioid butorphanol when given subcutaneously in goats. Subcutaneous administration might extend the half-life compared to intravenous or intramuscular administration. Eight clinically healthy, non-pregnant 6 months old female goats were used.

Syfte: Att jämföra patientens totala stråldos och undersökningstid från metoderna konventionell röntgen och genomlysning vid undersökningen belastade knän med artrosfrågeställning.Metod: Datainsamlingen utfördes genom att det delades ut dosprotokoll där röntgensjuksköterskorna på röntgenavdelningen fick skriva upp stråldoser och undersökningstid. Datainsamlingen gjordes under en fyraveckorsperiod på ett medelstort sjukhus i Sverige. Datainsamlingen jämfördes genom en hypotesprövning där det utfördes ett Mann-Whitney U-test med en signifikansnivå på fem procent för att se om nollhypotesen (ingen skillnad i stråldos eller tid) höll.Resultat: Studiens nollhypotes för stråldoserna förkastades som hade medelvärdet 444,37 mGycm² (genomlysning) och 212,24 mGycm² (konventionell röntgen). Nollhypotesen för undersökningstiderna förkastades också som hade medelvärdena 5,08 minuter (genomlysning) och 8,48 minuter (konventionell röntgen). Signifikansnivån för båda faktorerna var lägre än 0,001 och därför behölls mothypoteserna att det fanns en skillnad mellan modaliteterna.Slutsats: Studiens resultat visade att konventionell röntgen är den bäst lämpade metoden att använda stråldosmässigt medan genomlysningen är bäst lämpad tidsmässigt.

The main purpose of this study was to investigate the effects of the non steroidal anti-inflammatory drug (NSAID) meloxicam in connection with dehorning of goat kids. Six 2-3,5 weeks old dehorned kids were given daily intramuscular injections of meloxicam (0,5 mg/kg; MG) and five age-matched dehorned kids were given isotonic NaCl (NG) for 3 days. The study was randomized and double blinded. The behavior of the kids was studied one day before dehorning, on the dehorning day and three days after. Blood samples were collected each day before the treatment and analyzed for plasma concentrations of meloxicam, hematocrit, cortisol, progesterone and glucose.

In this study, the efficiency of a newly launched predatory mite, Amblydromalus limonicus, has been examined for its potential to use as a biological control agent in cucumber production. A. limonicus can be used for biological control of two thrips species, Frankliniella occidentalis and Thrips tabaci. Field trials were conducted in greenhouses of two conventional cucumber growers in Scania, the southern part of Sweden. The basic control agent used against thrips was the predatory mite Amblyseius swirskii. In selected areas, additional A.

Phenylbutazone has been discussed in the world of the equestrian sport several times and different countries have diverse opinions on its use in competitions. The progressive list that permits phenylbutazone with plasma levels up to 8 µg/ml was presented at the FEI General Assembly in November 2009. The list was voted to be accepted, but later several countries realized the consequences and after protests the list was rejected and is going to be discussed again at the FEI General Assembly 2010. In this literature study I have studied the relationship between the concentrations of phenylbutazone in plasma and the effects on lameness. The purpose was to establish whether the limit of 8 µg/ml phenylbutazone in plasma affects the equestrian sport.

The retrospective part of this study evaluates the susceptibility patterns of bacteria isolated from blood in critically ill foals in Sweden. The most commonly obtained bacteria were Actinobacillus spp. (38 %) and Escherichia coli (27 %). Trimethoprim-sulphonamide (TMS) had good efficacy against most gram negative bacteria with the exception of Klebsiella spp. Among 17 Escherichia coli isolates 94 % were susceptible to trimethoprim-sulphonamide whereas all 24 isolates of Actinobacillus spp.

Many media buyers annually spend money on advertising which will not be of benefit to their own brand; the fact that consumers confuse from which brand they have heard or seen commercials, comes as news to nobody. The phenomenon of media confusion has however earned much less attention. As a greater part of the total marketing budget is being spent on the media investments, on behalf of the actual advertising production, the more interesting it turns out to maximize the effects of the media expenses. The search for optimization is somewhat practised today by brand managers who are daringly adding a few more media channels to support their TV-campaigns. Buying ad space in TV is nevertheless much more expensive than the radio equivalent.

In modern industrial robots the components in the transmission contain nonlinearities. These nonlinearities need to be to estimated either for better control or to use the parameters for diagnosis of the system. There is a lot of work done within system identification and mainly within the field of iterative parameter estimation.This thesis considers recursive grey-box identification for a nonlinear model of the transmission in an industrial robot. The nonlinearities that are identified are friction, spring stiffnes, hysteresis and backlash. These nonlinearities are a part of the models that are presented in this thesis.