Grubbe Ventilation AB is a sheet metal and ventilation company who provides design, installation, service, and repair of ventilation. The company is expanding their business by building a new facility in Umeå, Västerbotten. The property is designed to be used for both office and industrial work.Grubbe Ventelation AB has not yet decided upon wish system which is to be established to provide the building with heating and cooling. The consulting firm Umeå Projekt Team has therefore been asked to investigate the possibilities to invest in geothermal- heating and cooling.If the investigation of a geothermal heating- and cooling system would provide favorable results it would be a very appropriate alternative that provides energy at low costs and are an environmentally friendly option as the energy comes from stored solar energy in the ground is provided by stored solar energy in the ground.The facility ´s heating and cooling consumptions are calculated in the program BV2 and the result indicate a heating demand of 185 000 kWh per year due to thermal transmittance, transmission losses, heating of warm water and a cooling requirement of 5500 kWh.Three different systems of geothermal heating and cooling were tested in the computer program Energy Earth Design. The results show no difference in the dimensioning of the drill hole if merely heating were to be used or both heating and cooling were to be established.

Background: The intention of this study was to clarify the patients perspective of what it means to suffer fiom documented restenosis after one or more Percutaneous Coronary Intervention (PCI). Aim: The aim of this qualitative study was to ascertain the patients experience of restenosis. Method: Nine patients were interviewed. They had undergone at least one PC1 and two had also undergone Coronary Arterio Bypass Grafting (CABG). Data collection and analysis were done simultaneously according to Grounded Theory methodology and were continued until new interviews provided no additional information, i.e saturation was met.

Background: Peripheral arterial disease (PAD), as a consequence of atherosclerosis in the arteria of the limbs, affects one of ten Swedes older than 65. PAD can develop slowly and silently, and involves an increased risk for cardiac infarction and stroke. Measurement of the patient´s ankle blood pressure and calculation of the ankle-brachial index is an evidence-based method to discover PAD. Objective: To investigate how district nurses and general practitioners perceive this method of examination and experience possible obstacles to why it is not more commonly applied at primary health care centres. Method: Data collected by semi-structured interviews have been processed by qualitative content analysis with a manifest onset.

The Swine flu (H1N1) erupted in 2009 and wasquickly spread over the world and developed into a pandemic, with a great threat against people?s health. It was soon discovered that the H1N1?virus had a different character than the seasonal flu, since it especially affected younger individuals and the consequences from the disease were expected to be more severe. In Sweden it was decided to provide a free of charge vaccination against the H1N1-virus, and the Swedish vaccination ratiobecome relatively high compared to other countries.

ABSTRACT. In the late 1960?s all the wolves in Scandinavia went extinct in the wild due to extensive hunting. In 1983 two new wolves immigrated and founded, together with a third immigrant in 1991, the population that exists today. Due to the fact that the population originates from less than a handful of individuals, the genetic variation is small.

The development of quantitative, real-time PCR (qPCR) combined with the mapping of the canine genome opens new possibilities in veterinary medicine. This method provides a quick and accurate quantification of the expression of a specific gene at a given point in time and thereby also information of how the gene expression for a certain protein is influenced by various conditions and diseases. One possible area of application is identifying bio markers for cancer. Recently the protein serglycin (the core protein of an intracellular proteoglycan) was found to act as a selective marker for the disease acute myeloid leukemia in humans (Niemann et al, 2007). Serglycin is produced by most hematopoietic cells, although mast cells account for the largest amount of serglycin.

Kugghjul är ett av de viktigaste elementen som finns i en maskin. Kuggväxlar har den högsta verkningsgraden bland kända energiomvandlare idag. Kuggväxlar har höga krav och det krävs en robust konstruktion för att göra dem okänsliga för störningar. Störningar på kuggväxlar ger upphov till transmissionsfel. Transmissionsavvikelser orsakar olika typer av oönskat beteende som exempelvis utmattning och buller är ofta en följd av tillverkningsavvikelser.I detta arbete har ett kommersiellt program, Helical3D, som bygger på kontaktmekanik och finita element metoden används för att studera inverkan av tillverkningsavvikelser på växelns prestanda i form av kontakttryck och transmissionsfel.

Bovine Respiratory Syncytial Virus (BRSV) is a common cause of respiratory disease among young cattle. The virus causes severe losses; the herd mortality rate can sometimes be as high as 20 %. In this study the avidity (i.e the antigen binding force) of BRSV specific antibodies was measured to see if there was a difference between antibodies produced during an acute phase of infection and antibodies produced by earlier infected animals. A commercially available ELISA-testkit against BRSV-specific antibodies was used and an incubation step with 6M urea was added. The effect of the urea is that it breaks the weak bonds between antibodies and antigen while the stronger bonds remain intact. Four different groups of animals were included in this study; seven calves that were naturally infected, three acutely infected calves with known time of infection, five cows that were seropositive during several years and four experimentally infected calves that had been a part of a vaccine trial. The results of this study showed that antibodies produced during the acute phase of an infection had a low avidity and that the avidity increased with time after infection.

Mastitis in dairy cows is an emerging and challenging disease in the tropics, including India. Nation-wide reports suggest that the incidence of clinical mastitis varies from 3.94% to 23.25%, and for subclinical mastitis from 15.78% to 81.60%. In Assam, a northeastern province of India, dairy is an essential part of the mixed farming system that exists in the state, but the milk yield is far below domestic standards. In 2009-2010, International Livestock Research Institute (ILRI) and local associates started to develop a training program for local farmers in Assam, in order to enhance the informal bovine dairy sector in and around Guwahati, India. The project continued until mid-2013.

Several factors affect the heifer´s growth and development, the newborn calf´s feeding of co-lostrum during its first hours of life is one important factor. The colostrum contains higher amount of immunoglobulins and insulin growth factors compared to matured milk. A high intake of immunoglobulins from colostrum results in a high blood concentration of immuno-globulins until the age of eight months. This leads to a lower incidence of diseases that can affect the growth and development negatively. Diarrhea is the most common disease in calves younger than 30 days.

I Sverige finns en hög frekvens av rotfyllda tänder med apikal parodontit och en praxis för behandling saknas. Denna studie syftar till att röntgenologiskt kartlägga progressionen av apikal parodontit vid rotfyllda tänder som ej blivit föremål för ytterligare endodontisk eller kirurgisk behandling och att identifiera variabler som påverkar progressionen för att ge ett bättre underlag för behandlingsbeslut. Röntgenbilder på rotfyllda tänder med apikal parodontit som lämnats utan åtgärd (n = 120) granskades avseende förändringen av den apikala parodontiten under minst en 3-års period under åren 2002-2011. Progression av den apikala parodontiten observerades i 22,5% av de studerade tänderna, trots att man sannolikt tidigare bedömt att den apika parodontiten inte behövde behandling eller att man kunde avvakta med behandling. Ingen av de studerade variablerna: den ursprungliga apikala parodontitens storlek, rotfyllningens längd, rotfyllningens täthet, typ av koronal restaurering eller den koronala restaureringens täthet befanns ha något samband med den apikal parodontitens progression.

Ticks and the diseases they transmit are of major importance throughout the world. In Uganda, cattle are the most important livestock from an economic point of view. Livestock keepers fear bi-directional transmission of tick-borne pathogens between their livestock and wild animals. This cross-sectional study was conducted to establish and compare the sero-prevalence of the tick-borne pathogen Babesia bigemina among randomly selected Ankole Long-horned cattle and European crossbred cattle on 30 farms in Kiruhura district, in two sub-counties near Lake Mburo National Park in South-western Uganda. Half of the farms were situated in close proximity to the park and thereby housed cattle with more frequent wildlife-livestock interface (Sanga), whereas the other half had less frequent contact (Kikatsi).

Acute bacterial prostatitis is a common disease in older male dogs. It gives symptoms such as fever, pain, tiredness, infertility, unwillingness to mate and sometimes symptoms from the urinary tract. It is common that you do an ultrasound exam on dogs when you suspect prostatic changes. In this study 15 dogs diagnosed with acute prostatitis at the small animal clinic at SLU in Uppsala were examined. The clinical signs and the ultrasound pictures were put together in retrospect.

About 35 years ago the WHO advocated that countries with injecting drug users should introduce the so-called needle exchange programs (NEP) to curb the spread of infection by blood-borne diseases. In Sweden the first NEP started 1985 in Lund, but the program was extremely controversial in a country with such a restrictive drug policy like Sweden.The study you are about to read shall process this controversy, when a NEP opened in Stockholm, by analyzing the articles published in the newspapers Dagens Nyheter and Svenska Dagbladet. By using discourse analysis as a processing tool we?ll try to see the difference between the two chosen newspapers. We will identify and analyze the different participant?s, such as doctors, politicians, user associations and media, arguments in the needle exchange issue.

Exoner är de sekvenser i DNA vilka rymmer koden för proteiner i människan och i alla andra organismer. Intronerna, vilka utgör utrymmet mellan exoner, består av ickekodande sekvenser och kontrollelement. Exoner tillhörande en gen måste inte alltid inkluderas i den slutliga mRNA produkten, alternativ splicing tillåter exkludering av vissa sekvenser och gör att en gen kan ha mer än en mRNA produkt, därigenom kan en gen koda för flera olika proteiner. Alternativ splicing är ett fält som snabbt utvecklas och dess relevans för många sjukdomar har blivit uppenbar. Detta arbete går igenom ett flertal av dessa sjukdomar för att sammanställa ny forskning och tydliggöra rollen av alternativ splicing i dem.