This study was conducted at the University of Bath, UK, from September to December 2014 as part of an ongoing research project aimed at elucidating how the Grb10 gene might act as a mediator of long-term health effects (such as predisposition to obesity, diabetes, coronary heart disease and hypertension) caused by environmental factors during development. This phenomenon is known as developmental programming. The purpose of this thesis was not primarily to answer any of the broader questions posed by this research project at large since this would require much more data than is reasonable to acquire over the course of a few months, but rather to evaluate the methods used in this project and reveal whether they are working the way they are presumed to. In the research project, which employs mice with the Grb10 gene knocked out as well as wild-type control mice, a dietary restriction model is utilized during gestation, which is supposed to generate offspring with lower birth weight and subsequent detrimental health effects in adulthood. This is supposed to be achieved by restricting the protein content of the pregnant mothers? diet to 9 % (as opposed to the control diet of 20 %) throughout gestation.

The Swedish public inquiries and most of the political science advocate reforms in the spirit of participatory democracy to strengthen the democracy. Although it is striking how limited and narrow the scientific documentation is in analysing the effects of participatory democratic reforms. Still, many of the local governments in Sweden are reshaping their organisations according to the participatory democracy model. Is it a trend and a symbolic action or a veritable action of good-will of the politicians?The paper argues that the idea of participatory democracy has become popular and widely spread.

In 2010, SAS received the "On time performance service" award by Flightstats. This award was an affirmation of long-term work, both in projects and as an ongoing process, which the company sought to systematically improve punctuality on its flights. The extent to which SAS followed the values and the underlying theories of the cornerstone model for total quality management was the main issue in this essay. Whether there are conditions for the company to get even further by working in other ways was also investigated. In addition, the importance of punctuality in relation to customer satisfaction was discussed.

Mechanical ventilation is the most common type ofventilation in newly constructed office buildings. Therehas been an interest to utilize natural ventilationinstead of mechanical ventilation among architects andHVAC consultants in recent years. This is due to thesize of mechanical ventilation systems, which arespace consuming. The mechanical ventilation system isalso complex and requires maintenance. Furthermore,the fan uses a considerable amount of energy.

Purpose: To investigate if Altman´s Z´-score model, which calculates financial distress, can be applied on companies established in Sweden and if the financial crisis in 2008 made previously healthy companies go bankrupt.Methodology: Quantitative studies with a positivistic foundation. Empirical data will be collected in order to examine if there is generalizability among the studied objects. Conclusions will be made by comparing the empirical data with the theoretical foundation. Financial distress in firms will be measured.Theoretical perspectives: Altman´s Z´-score model, designed to predict financial distress in private firms.Empirical foundation: A selection of 93 private firms that have gone bankrupt in the years 2008, 2009 or 2010. The firms selected all have a turnover that exceeds 20 million SEK.

Tidigare ombesörjde organisationen karriär och karriärutveckling för den anställde och karriärkontraktet byggde på livslånga anställningar. Det nya karriärkontraktet bygger istället på en så kallad proteisk karriär (Hall, 1996), vilket utmärks av att individen ser sig själv som ansvarig för och drivande av sin karriär, att egna värderingar får styra samt att psykologisk utveckling är främsta mål. Studiens frågeställning var att undersöka om personlighetsfaktorer i termer av self-efficacy, självkänsla, locus of control samt neuroticism kan predicera proteiska karriärattityder. I studien användes kvantitativ metod och en enkätundersökning genomfördes på studenter. Korrelationsberäkningar visade att samliga personlighetsfaktorer samt proteiska karriärattityder var korrelerade.

The impact of computer programs in safety-critical systems has increased in the past decades and computer-based systems can now be found in a wide range of applications. A new approach for developing dependable systems is documenting all design rationale that affects safety using Intent Specifications. A recent approach for developing complex systems efficiently and in an upgradeable manner is Component-Based System Engineering. In this thesis, these approaches are combined in the development and upgrade of a Remote Robot Control Unit by using the tool SpecTRM. The case study showed that Intent Specifications and CBSE could successfully be combined.

This bachelor thesis has the purpose to visualize and document the air movementsprovided by different ventilation principles in an operating theatre. The visualizationwill be made as simple as possible in a physical model. The model and thedocumentation should be able to use in educational purposes.The study is based on the two most common systems for airflow, currently used inoperating theatres. The first principle is displacement ventilation in which the air issupplied at low velocity along the floor. The second principle is vertical parallel laminarairflow in which the air is compressed like a piston from ceiling to the floor.A review of literature resulted in the choice of size, design, and scale factor for themodel, as well as choices of ventilation principles and airflows.

Background: Since the start of the twenty-first century it has become very important for companies to act in a responsible manner, in guides of CSR. The idea is that companies have more responsibilities than to achieve a higher profit for their shareholders. They should also care about the society and act in a responsible way.Problem discussion: Problems concerning CSR are that the internal part of the sustainability work has not encountered the same level as the external part of the sustainability work. Companies are today struggling with implementing CSR into their business strategies.Research questions:1. What does a company has to consider when working with CSR? 2. How can management control systems help the implementation of CSR into the organisation?Purpose: The purpose of this thesis is to examine what a company has to consider when working with CSR and how management control systems can help the implementation of CSR into the organisation.

This bachelor thesis has the purpose to visualize and document the air movementsprovided by different ventilation principles in an operating theatre. The visualizationwill be made as simple as possible in a physical model. The model and thedocumentation should be able to use in educational purposes.The study is based on the two most common systems for airflow, currently used inoperating theatres. The first principle is displacement ventilation in which the air issupplied at low velocity along the floor. The second principle is vertical parallel laminarairflow in which the air is compressed like a piston from ceiling to the floor.A review of literature resulted in the choice of size, design, and scale factor for themodel, as well as choices of ventilation principles and airflows.

An automatic control system for calibration of pressure indicators has been constructed. This control system can be used as a complement to the calibration system located at AerotechTelub, division MainPartner, in Linköping. The calibration system used today contains some not wanted pressure changes, which is compensated by hand today. The new system presented in this report automates the calibrating process and simplifies the calibration. Suitable hardware as motor, controls card and so on have been found and software in the form of Visual Basic program has been developed.

The aim of this Master?s thesis is to investigate and increase the understanding of Swedish Public Library Websites and to determinate which activity they mediate. To analyse the Public Library Websites Andersson and Skot-Hansen?s model of roles for the Public Library has been used. This model in¬cludes four roles for the library: the library as a cultural centre, a knowledge centre, as an information centre and as a social centre.

This paper analyses how Swedish fine-art oil paintings sold at auctions has performed as a monetary investment during the period autumn 1985 until spring 2006. An average price technique as well as a hedonic regression technique, applied to a sample of 19 213 auction sales, is used to construct price indices. The indices show somewhat different results, which is explained by the inability of the average price model to adjust for relative differences in quality between periods. The hedonic regression model on the other hand captures this effect, why the hedonic index is applied in a financial return model. By adjusting for transaction cost, the financial return of an average investment in paintings is calculated.

This Master Thesis treats the non monetarian aspect about the Internet Portal from a consumer and company perspective. The purpose of this thesis i st o give or create a picture and a tool, a model for how the Internetportal could be evaluated an valued. By creating a so called Dynamic Scorecard the authors of this Thesis have created a model throug which the purpose of this thesis is served. Through this model the authors have come to the conclusion that the Internet Portal can be evaluated through both economic, social, service and technical factors as well as through what relationship the companies or consumers value concerning the Internet provider. The product of conclusions of this Thesis is that there are three main factors upon wich the Internet Portal is valued.

Introduction The genetic skin disease epidermolytic ichtyosis is caused by mutations in either keratin gene 1 or 10 and leads to blisters and hyperkeratosis of the epidermis. At cellular level the disease is seen as aggregates in the keratin filaments. Since medicines are hard to investigate and produce mainly due to lack of reproducible model systems, there is no good treatment available for this disease today. In this article we describe how an in vitro model consisting of cells from a stable cell line transfected with expression plasmids to mimic patient cells, may be a possible alternative for screening compounds for therapies. The first step was to generate an expression plasmid required to complete the in vitro model.