The process of drug discovery is very slow and expensive. There is a need for reliable in silico methods; however the performance of these methods differs.This work presents a targeted study on how the drug discovery methods used in OpenEye?s tools ROCS, EON and FRED perform on targets with small ligands. It was examined if 12 compounds (markers) somewhat similar to AMP could be detected by ROCS in a random data set comprised of 1000 compounds. It was also examined if EON could find any electrostatic similarities between the queries and the markers.

This thesis describes new methods for automatic crack detection in pavements. Cracks in pavements can be used as an early indication for the need of reparation.Automatic crack detection is preferable compared to manual inventory; the repeatability can be better, the inventory can be done at a higher speed and can be done without interruption of the traffic.The automatic and semi-automatic crack detection systems that exist today use Image Analysis methods. There are today powerful methods available in the area of Computer Vision. These methods work in higher dimensions with greater Complexity and generate measures of local signal properties, while Image Analyses methods for crack detection use morphological operations on binary images.Methods for digitalizing video data on VHS-cassettes and stitching images from nearby frames have been developed.Four methods for crack detection have been evaluated, and two of them have been used to form a crack detection and classification program implemented in the calculation program Matlab.One image set was used during the implementation and another image set was used for validation. The crack detection system did perform correct detection on 99.2 percent when analysing the images which were used during implementation.

This thesis presents an adaptive tuning system that can be described as a dynamic Just Intonation tuning system, being compatible with equally tempered instruments. The tuning system is called Hermode Tuning (HMT) and the tuning used as comparison for evaluation is the standardized western tuning, the equal tempered tuning. This study investigates preferences for these two musical tuning systems, depending on whether the tunings are presented on a piano or with woodwind instruments. A listening test was done with students at the Falun Conservatory of Music, including both a vertical listening (intervalls) and a horizontal listening (cadenses and musical compositions) of Hermode tuned musical material. Overall the results showed no significant preferences for either tuning system irrespectively of what instrument it was presented with.

Generally prosody is described as the rhythmic, dynamic and melodic features of language. Prosody is further often described as suprasegmental, since its properties go beyond vowels and consonants, which are segmental characteristics of language. A relationship between prosody and music has been noticed and described for several decades. At present, there are several studies proving relationship between prosodic and musical abilities. The aim of the present study was to construct a test for prosodic non-linguistic perception and production regarding intonation and rhythm. The test was tried out on 16 children with typical language development aged 4;6-7;6 years. Before testing of ITAP each participant were asked about musical experience.

The purpose of this paper is to examine information sharing in a hospital organization that is undergoing reorganization. The aiming is to make all employees at all levels actively involved in business development in order to create a smooth and, from a patient?s perspective, adequate emergency care. The paper suggests that the theory of social capital can explain the Complexity of what motivate and what promote individuals to share information. The method used in the paper is the case study, focusing on detecting, interpreting and gaining insight on how information shares in an emergency department.

In Sweden, prostitution is politically defined as a social problem, more precisely, as a form of male violence against women. The definition is distinctly manifested in the government bill Kvinnofrid, characterised by the unique Swedish law that prohibits the purchase of sexual services.This thesis examines how the Swedish solutions of prostitution are carried out. By interviewing central actors working with prostitution in different ways we aim to answer the question: What measures are taken to decrease prostitution and what implications does the Swedish solution have?The analysis is divided into two parts. First, we analyse the concrete measures taken against prostitution ? what is done, how, and why? Second, we analyse the Complexity of prostitution measures by applying complementary analytical perspectives: the symbolic and the discourse perspective.The study shows that measures taken to decrease prostitution vary and depend on individual actors? understandings of the political definition.

This study is based on interviews with four managers in public elderly care and four managers in private elderly care. The aim of this paper is to examine how these managers are experiencing their leadership in relation to conflict management, and if the managers leadership differs depending on private or public elderly care. Leadership and conflict management are theories that have been used in order to analyze the empirical findings. Previous research that has been used in the study concerns ?leadership/leadership styles?, ?conflict management?, ?to be active in the private/public elderly care?.

The works of an employee within an authority involves many laws and rules that have to be followed at the same time every case is unique and the resources are limited. This study wants to illustrate how national environmental goals are applied by länsstyrelserna in Sweden. How does the implementation of the environmental goals works by länsstyrelserna in Blekinge, Skåne and Örebro län? Which problems creates obstacles in the implementation of the environmental goals according to länsstyrelserna? What differs between länsstyrelserna in the implementation? Mainly it is the Complexity of problems that will be illustrated here, which may result in different implementation sof the environmental goals by länsstyrelserna or that the environmentalgoals do not applys like intended. In this study sixteen national environmentalgoal are examined; ?fresh air?.

Trough the contact with the HR (Human Resources) department of home care management in Halmstad municipality, emerged from the management a wish for a documentation for what should be included in leadership at middle management level in the future. People in middle management positions have a large impact on the operation staff and are also in charge of the individual corporate performance and its success. As we have previously been active in the management of multiple role configurations, including middle-management positions, we have some prior understanding of the Complexity of this position. The study was conducted with the aim to investigate different aspects of what leadership for middle managers in home care management in Halmstad municipality may mean to them. With the help of different theories and models various aspects were analyzed due to the impact of leadership.Due to the studies purpose and questions, two focus groups was conducted and interviews with respondents from both the lower and superior positions in home care management in Halmstad municipality was done.

The focus of this essay is set on a number of processes that affect the challenges of the tourist trade, to be more precise ? an analysis of the attitudes towards tourism and sustainability within this line of business ? from an ethical and moral as well as social view. These issues are examined with reference to the concept of CSR (Corporate Social Responsibility). Thus, acquaintance with theories of social constructivism, post colonialism, globalisation and global civil society is essential in order to understand the analysed material. The essay is mainly based on the outcome of qualitative interviews with various kinds of persons working with CSR related questions.

Environmental chemicals are transported to the Arctic through the air and oceans, once within the Arctic they spread through rivers, lakes and other watercourses. Polar bears and sledge dogs in-gest high concentrations of environmental chemicals since many of the chemicals are fat-soluble and their diet mainly consists of marine mammals. The aim of this study is to describe how environmental chemicals spread in nature, how they reach the polar bears, and finally how they affect the animals reproduction, with reproductive hormones and genitals in focus. The animals are exposed to a cocktail effect which complicates the assessment of the chemicals impact on the reproduction. Studies show that the genitals can decrease in size or become malformed, sexual maturation can be affected and the reproductive hormones can be disturbed.

Projects is the most common work model within the cultural area, but what is a cultural project? The definition of cultural projects is ambiguous. There are also no compiled information about what it means for culture to be pursued in project form. Scientific research about traditional project management and success criterias are wide-ranging. So is the scientific research about cultural studies and cultural policy.

With an increased empowerment of the users, and a dependence on outside critics, one wonders what kind of role the librarians have in a context where qualitative literature is discussed. The aim of this study is to examine the relationship between librarians private and professional views on qualitative fiction, in order to be able to discuss their role as quality intermediaries in a user oriented context.The method used, is the qualitative, semistructured interview. This author interviewed seven librarians from three different libraries in Sweden. The theoretical emphasis partly relies on the ten words of qualitative value that Inger Elam and Bengt Brülde discusses in their respective texts, partly on David Garvins quality assessment theory, which defines several quality categories divided between an absolute and a relative quality view.Through the comparison between the private and the professional quality view, examined with the two theoretical approaches, the analysis of the interview material shows that there lies a Complexity in the librarians professional role. On the one hand, they are dependent of both the users and the critics judgements about the qualitative aspect in the work with purchasing new literature to the library.

 The aim of this study was to examine how social workers perceive and interpret the term ?barnets bästa? (?The best for the child?), within the framework of investigatory work and enforcement of Swedish law, which is carried out by the Social Services. We wanted to investigate if the interpretation of the term had any causal effects on the work carried out by social workers. Seven social workers from two municipalities participated in this study in which we used qualitative semi-structured interviews based around two vignettes. We focused on age, experience, legislation, and external circumstances to gain insight into how these factors alter social workers? perception of the term ?barnets bästa?. Our theoretical approach was based on two theories on social constructivism.

The purpose of this dissertation is to create an understanding of how a personal idea in the mind of an entrepreneur becomes an outspoken vision in one biotech company. More specifically, for what purpose the vision is used at different stages, how it is communicated, its content and what impact previous visions have on future vision work and in order to reach a deeper understanding of how vision develops over time and how it is used we have employed a qualitative approach based on a case study. The theoretical framework starts with the concept of vision and related concepts. Furthermore, the entrepreneur?s and manager?s usage of vision is examined.