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600 Uppsatser om Clinical trials - Sida 3 av 40
Askåterföring värt besväret? : en fallstudie av följderna av Stora Ensos försöksverksamhet med askåterföring
This thesis reports on a case study of a forest company, Stora Enso, and their experience from a number of trials and experiments with ash recycling. A literature survey and a total of eleven in-depth interviews were carried out. Ash recycling was found to be the concern of three different divisions of the company. The pulp industry which produces the ash, the forest division which would be responsible for identifying land and spreading the ash, and Stora Research, which has had a major part in the design and implementation of research trials. Lacking an overall company decision on ash recycling the matter is left to the individual divisions.
Mediebilder av homosexualitet. Åke Green-debatten
The purpose of this thesis is to study how homosexuals and homosexuality were represented in the press during the trials against the Pentecostal pastor Åke Green, and to what kind of social representations and narratives these representations can be related.Using critical discourse analysis and theories about the differentiation between in- and outgroups I try to unveil implicit meanings and attitudes towards gay people mainly at the local text level. The material consists of articles in Ölandsbladet and Dagens Nyheter that were produced before, during and after the trials.The analysis suggests that homosexuals are construed as a deviant outgroup and that the majority, the ingroup, is presented as an essentially heterosexual, tolerant community. Homosexuality is wrong and heterosexuality is the right way of living. Homosexuals, in terms of group lobbyism, are construed as an enemy, a threat, against Western ideals such as family values and freedom of speech. They indirectly become a threat to Swedish democracy.
"Att orka vara själavårdare" : En jämförande studie av copingresurser i pastoralkliniskt och kontextuellt själavårdsparadigm.
This study aims to find coping resources in two different paradigms of pastoral care using coping theory from the psychology of religion. The intention is to find coping resources that are functional coping strategies to help priests and chaplains in their work with pastoral care. The research questions are: What coping resources can be found in the pastoral clinical paradigm and the contextual paradigm? What are the differences and similarities? The method used is template analysis style where the theories form a framework for the material used to analyse in this study. The theories used for this study are religious coping theory and pastoral care theory.
Clinical Innovation Fellowships : Uppföljning av en ny metod för förändringsarbete inom sjukvården
Centrum för Teknik i Medicin och Hälsa (CTMH) har, i samarbete med Stanford University, utvecklat programmet Clinical Innovation Fellowships (CIF) för att identifiera förändringsbehov inom vården. Syftet med den här uppsatsen är att undersöka huruvida arbetssättet med Clinical Innovation Fellowships har åstadkommit förändringar för patienter, medarbetare och ekonomi på värdklinikerna.Undersökningen har visat att arbetssättet med CIF framförallt har åstadkommit förändringar för medarbetare. Även förändringar för patienter har genomförts, dock har den ekonomiska aspekten av programmet varit svårare att mäta och se några konkreta förändringar inom.Det har gått att tyda en generell trend som visar att de undersökta värdklinikerna valt att börja med de förändringar som är av mer praktisk natur och enklare att genomföra lokalt på kliniken. Värdklinikerna har haft svårare att genomföra större, organisatoriska förändringar, vilka styrs mer centralt på sjukhusen. Undersökningen på de utvalda värdklinikerna visade att något som skulle gynna CTMHs arbetssätt med CIF skulle vara att etablera en uppföljning på klinikerna.
Escherichia coli-mastitis in dairy cows :
Escherichia (E) coli is one of the most common udder pathogens associated with acute clinical mastitis in Swedish dairy cows. The aim of this study is to review some of the existing literature on E coli mastitis from a Swedish perspective. The bacteria, its most important characteristics, and diagnostics under field conditions is covered, as well as what happens during infection, how E coli affects the cow and which consequences this have. Clinical symptoms associated with E coli mastitis are described and information on when these cases of mastitis usually occurs is given. Risk factors in the cow?s enviroment are described as well as the importance of the cow?s immune defence.
Utvärdering av Komm-A, en modell för arbete med kommunikationsbok för personer med afasi i logopedisk verksamhet
The purpose of this study was to evaluate Komm-A, a model for usingcommunication books in clinical practice for people with aphasia. The studyconsisted of two group studies and one case study. One of the group studies had apretest-posttest design and consisted of nine couples; a person with aphasia andhis/her communication partner. The material used was Quality of communicationlife scale (QCL), Communicative effectiveness index (CETI), Goal attainmentscaling (GAS), and a questionnaire to the communication partner. The other groupstudy consisted of seven speech-language pathologists who worked with thecouples according to the Komm-A model.
Utveckling av metod för utvärdering av synnervens funktion hos häst :
VEP, visual evoked potential is an electrophysiologic test that can be used for evaluating the higher visual pathways. The aim of this study was to investigate if it is possible to adapt this method to horses. This method could have a clinical use in addition to the existing diagnostic methods that are available to evaluate vision in horses.
Firstly, this study contains a summary of relevant studies done on animals and, secondly, an experimental part where the possibility of recording VEP in nonsedated and sedated horses is investigated and where to position the recording electrode to obtain the best results.
Our results show that it is possible to record VEP in horses in a clinical setting. VEP was best recorded in the sedated horse to avoid movement artifacts and other disturbances.
Träning och manuell behandling för att minska impingementliknande symptom i skuldran hos idrottare? : En systematisk litteraturstudie
AimThe purpose of this study is to investigate whether there is scientific evidence that exercise and/or manual therapy can improve function, in terms of increased mobility and strength on shoulder impingement-like symptoms among athletes. Another aim is to investigate whether these interventions can reduce shoulder pain.MethodA systematic review was conducted in the databases PubMed, CINAHL, PEDro and Amed. A total of thirteen articles were selected for further review and compilation. They were then graded for level of evidence according to the PEDro scale and the Swedish Council on Technology Assessment (SBU).ResultsThe systematic review shows that there is strong scientific evidence that acupuncture and heat can reduce pain in athletes diagnosed with supraspinatus-tendiopathy. There is limited scientific evidence that exercise increases strength, limited scientific evidence that stretching increases mobility and insufficient scientific evidence that a combination of treatments, with both exercise and stretching, reduces pain and increases function in overhead athletes.ConclusionsExercise and manual therapy can reduce pain and/or improve function in terms of increased mobility and strength in athletes with shoulder impingement-like symptoms.
Studier av alkaliskt fosfatas och kollagen samt deras betydelse för skelettets mineralisering
There is convincing research which shows that the enzyme alkaline phosphatase (ALP) has a central role in the mineralization of bone, more precisely that its catalytic activity is needed in the process. ALP is found on the surface of matrix vesicles where the mineral is formed. One theory about the function of the enzyme is that it binds to fibrous collagen in the bone and thereby incorporating the mineral into the bone. The purpose of this study is to establish whether ALP binds to collagen. If this is the case, more elaborate studies around this will be performed.
Hypoadrenokorticism hos storpudel :
Hypoadrenocorticism (Addison´s disease) results from insufficient production of glucocorticoid and mineralcorticoid hormones from the adrenal glands. The disease is often difficult to diagnose in an early stage because of the multitude of associated vague clinical signs. The standard poodle is one breed presupposed to be at higher risk of developing the disease. The purpose of this study was to give a review of canine hypoadrenocorticism as described in literature, and to characterise Addison´s disease in a population of standard poodles in Sweden. Statistics on incidenceproportions by breed for hypoadrenocorticism from the database of the Swedish insurance company Agria are presented.
Insättningsrutinernas effekt på tillväxt samt effekten av klinisk sjukdom på ätbeteendet hos kalvar i gruppbox med automatisk mjölkutfodring :
The aim of the present study was to investigate the effect of strategy for grouping calves into group pens with automatic milk-feeding systems on the calves' health and growth rate. The usefulness of changes in feeding behavior recorded by the computerized milk-feeder during periods of illness to identify calves with clinical diease was also studied.
In the first experiment, 64 calves were moved in and out of group pens in a continuous way, while 46 calves were transferred into group pens until the the pen was considered "full". The calves in the latter groups were then held together until weaning. It was found that calves in the fixed groups grew approximately 100 g / day more compared to the calves in the dynamic groups. Signs of clinical respiratory disease were less frequent in this group, while the incidence of diarrhoea was slightly higher.
In the second experiment health parameters, milk consumption and feeding behaviour was recorded daily for 46 calves.
Ett nytt hjälpmedel för läkemedelstillförsel till hästögon
Medicinering vid sjukdomstillstånd i det främre segmentet av ögat hos häst är ofta tidskrävande och komplicerat för djurägaren. Syftet med studien var att undersöka om ett nytt tekniskt hjälpmedel, en spiral som kallas OphthaCoil, fungerar för långtidsmedicinering hos häst. Två olika designer på spiraler utvärderades. Efter en ögonundersökning placerades en spiral i nedre konjunktivalsäcken och hästen observerades till dess spiralen trillade ur. Resultaten visar att ingen av de använda designerna låg kvar tillräckligt länge för att kunna användas för en längre tids behandling.
Utvärdering av en snabbtest för diagnostisering av hypokalcemi hos nötkreatur :
Clinical signs of hypocalcaemia in dairy cows are easily recognized, and a rapid response to treatment generally confirms the diagnosis in the field. However, clinical signs of other disorders in cows, such as toxemia, calving paralysis, or muscoskeletal injury, may mimic those associated with hypocalcaemia. Therefore, making a diagnosis of hypocalcaemia on the basis of clinical signs alone may be difficult. In ambulatory veterinary practices, cow-side tests are useful to make the diagnosis and prognosis easier.
Kruuse?s Kalcium Test is a cow-side test based on the principle that calcium ions are necessary for coagulation of blood, and that chelation with EDTA prevent coagulation.
Kliniska prövningars inverkan på läkemedelsföretagens aktiekurser
Bakgrund: Läkemedelsbranschen är idag en av de mest reglerade branscherna på marknaden. Forskning och utveckling har en stor betydelse för läkemedelsföretagen. För att lansera ett läkemedel krävs det att företagen genomför kliniska prövningar, deras utfall kan mycket väl avgöra företagens framtid.Problemformulering: hur stor inverkan har de olika faserna inom produktutvecklingen på aktiekurserna för företag i läkemedelsbranschen.Syfte: Syftet med uppsatsen är att undersöka hur marknaden reagerar när läkemedel som är under utveckling går in i de tre olika kliniska faserna.Metod: Studien baseras på kvantitativ data där ett bekvämlighetsval gjorts på sju stycken läkemedelsföretag. PR meddelanden där läkemedel i utveckling går in i fas-1, fas-2 och fas-3 kliniska prövningar har valts ut som enskilda händelsen i eventstudien som genomförts. Vi har studerat vad som händer 5 dagar före och 5 dagar efter att händelsen utspelar sig.
Höftledsdysplasi och armbågsledsartros hos labrador retriever med känt radiologiskt status av höftleder och armbågar : en tredje uppföljande studie
Joint-related diseases including hip dysplasia (HD) and elbow arthritis (ED) can in advance cases lead to that the dog has to be put down, and these diseases are also the cause to expensive veterinary treatments of many large breeds, including Labrador Retrievers. The aim of this study was to make a follow-up study on the 271 Labradors, who previously participated in a study on the effect of nutrition and exercise on hip and elbow status in a birth cohort born year 2000. That study investigated the relationship between nutrition, exercise, and HD and ED. A follow up study on the same dogs at 5-6 years of age investigated the clinical effects of the radiological hip and elbow status at 1 years of age and if was effected by body condition score. This study took place in 2011-2012 and 187 Labrador retrievers participated.