Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

Denna tvärsnittsstudie syftade till att undersöka samförekomst av smärtrelaterad rädsla och social ångest i ett kliniskt sample med kronisk smärtproblematik. Syftet var också att beskriva och kontrastera samvariation av transdiagnostiska faktorer i eventuella subgrupper. Datan bestod av enkätsvar från 196 deltagare i Social ångest smärta-projektet som leds av Örebro universitet och Akademiska sjukhuset i Uppsala. En klusteranalys fick fram fyra subgrupper bland deltagarna. En subgrupp utmärkte sig för hög komorbiditet.

Bakgrund: Crohns sjukdom och ulcerös kolit är två huvudtyper som utmärker inflammatorisk tarmsjukdom. Inflammatorisk tarmsjukdom påverkar mag- och tarmkanalen och har ett oförutsägbart sjukdomsförlopp. Inflammatorisk tarmsjukdom debuterar vanligtvis i åldern 15-30 och kan ge ogynnsamma konsekvenser i personens dagliga aktiviteter eftersom han eller hon är upptagen med att exempelvis studera, skapa karriär eller bilda familj. Sjukdomarna har flera gemensamma särdrag där de förekommer i så kallade skov med perioder med försämring då tarmslemhinnan blir inflammerad och sårig, vilket leder till symtom som exempelvis blodiga eller slemmiga diarréer, viktnedgång, buksmärtor och trötthetSyfte: Syftet med uppsatsen är att beskriva konsekvenser av att leva med Crohns sjukdom eller Ulcerös kolit hos vuxna personer.Metod: En litteraturöversikt. En litteratursökning gjordes som ledde till sex granskade artiklar.

Staphylococcus aureus is the most clinically important Staphylococcus species and is associated with high mortality in patients with positive blood cultures. S. aureus bacteria may cause a variety of disease manifestations ranging from minor skin infections to life-threatening conditions such as pneumonia, meningitis, osteomyelitis, endocarditis, toxic shock syndrome (TSS) and sepsis. This microorganism belonging to the gram positive cocci may also be part of the normal flora. In Sweden, penicillinase-stable penicillins are the primary alternatives to treat S.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

Denna studie undersökte samsjuklighet mellan smärta och social ångest i en smärtpopulation genom klusteranalys. Syftet var att undersöka om det fanns en undergrupp bland smärtpatienter som skattade högt på social ångest samt högt på upplevd invalidering före och efter smärtbehandling. Syftet var vidare att se om denna undergrupp skattade annorlunda vad gäller funktion jämfört med smärtpatienter med låg grad av social ångest samt se hur individer rörde sig mellan kluster över tid. Data bestod av självskattningsformulär från 157 smärtpatienter. Resultatet visade att det fanns en undergrupp som skattade högt på social ångest och upplevd invalidering.

Causes of thrombocytopenia in dogs ? a retrospective study of 123 cases The purpose of this retrospective case study was to determine which diseases are associated with thrombocytopenia in Swedish dogs. Records of 123 dogs with thrombocytopenia were evaluated. The most common cause was neoplasia-associated thrombocytopenia (32%). The largest proportion within this group was unspecified neoplasia.

Shivering är ett fenomen som uppstår hos patienterna postoperativt. Det innebär att patienten har okontrollerbara muskelskälvningar som gör att patienten darrar, skälver eller huttrar i mer än 15 sekunder. Shivering påverkar kroppen negativt, men är också obehagligt och ett onödigt lidande för patienten. I takt med den tekniska utvecklingen utarbetas nya operationstekniker och idag utförs flera operationer med laparoskopisk teknik. Pilotstudiens syfte var att undersöka före-komsten av postoperativ shivering hos patienter som opererats med laparoskopisk teknik.

Kronisk njursvikt ökar varje år och vid terminal njurinsufficiens ses njurtransplantation som förstaval av behandling. Behovet av donerade njurar är större än tillgången, vilket leder till en lång väntan för individen. Studiens syfte var att beskriva individers upplevelser i väntan på en njurtransplantation. Metoden var en litteraturstudien där tio vetenskapliga artiklar granskades och analyserades. I analysen framkom tre teman som utgjorde resultatet: behandling för att överleva där dialysbehandlingen sågs som en begränsning i livet och gjorde det svårt att leva som dem gjort tidigare, känna hopp där en transplantation var något att hoppas på, ett sätt att ta sig ur dialysen och få tillbaka sitt gamla liv, samt känna hopplöshet där rädsla för att njurtransplantationen aldrig skulle bli av och känslor av att vara på is i väntan uppkom.

This student report is about canine atopic dermatitis It includes a description of the immunologic mechanisms and how the reaction affects the body. The symptoms are various, most common is pruritus, erythema and alopecia and directly associated with the immunologic reaction. The diagnostic process includes symptoms, physical findings, differential diagnosis, intradermal test and serological test. The options of treatment are several and vary for each patient. The report includes hyposensitization, medical treatment such as corticosteroids, antihistamin and cyclosporine, topical treatment, fatty acid supplements and environmental treatment. The prognosis is individual for each patient due to their different response to the treatment. It may take a while to find the right combination of treatments to achieve satisfactory control of the disease..

Elderly patients experiences of palliative care ? a rewireThe purpose of this paper was to study elderly patient?s experience of palliative care with present knowledge as starting point. The questions were; what criteria do the elderly, dying person think is most important to fulfill in palliative care? and how satisfied is the elderly, dying person with the palliative care that are giving to him/her? The information were collected by a data based search trough science magazines and technical literature. Four relevant studies were found; Costello (2001), Heyland (2005), Wilson (1999) and Formiga (2004).

Elderly patients experiences of palliative care ? a rewireThe purpose of this paper was to study elderly patient?s experience of palliative care with present knowledge as starting point. The questions were; what criteria do the elderly, dying person think is most important to fulfill in palliative care? and how satisfied is the elderly, dying person with the palliative care that are giving to him/her? The information were collected by a data based search trough science magazines and technical literature. Four relevant studies were found; Costello (2001), Heyland (2005), Wilson (1999) and Formiga (2004).

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

Syftet med denna studie var att beskriva erfarenheter av förändringar i dagliga aktiviteter hos kvinnor med långvarig smärta. Data samlades in via semistrukturerade intervjuer med sju kvinnor, alla över 50 år. Kvinnorna fick berätta om sina erfarenheter av förändringar i dagliga aktiviteter. Analys av data genomfördes med kvalitativ innehållsanalys vilken resulterade i tre kategorier: ?Förändrat umgänge och aktiviteter med andra?, ?Utförandet av aktiviteter är förändrat? och ?Förändrad aktivitetsrepertoar?.