Our study aims at investigating the unit manager?s, within LSS, perceiveddiscretion, when people with Down´s syndrome develop Alzheimer?s disease. We wanted to know what they perceive as limiting factors or facilitators in order to meet changing and/or emerging needs, as well as how they interpret their discretion in relation to this. We have conducted semi-structured qualitative interviews with five unit mangers within LSS.When analyzing the interview material, we have used a theoretical approach from a street-level bureaucracy and from the unit managers? perceiveddiscretion point of view.Our study?s result demonstrate that the unit managers are experiencing a wide discretion and do not feel a need to widen their identifieddiscretion..

Amyotrophic lateral sclerosis is one of the major neurodegenerative diseases, causing an ascending paralysis that usually kills the patient within a few years from disease onset. The motor neurons show aggregates of proteins which in approximately 20 % of cases of the familial form contain mutated SOD1 protein. Trehalose is a disaccharide which has been shown to reduce protein aggregation and increase viability in cell models and alleviate symptoms in animal models of several neurodegenerative diseases associated with protein aggregation. When given orally to the SOD1G93A mouse model of ALS, trehalose failed to slow down the disease progression, which has led to questions about the uptake and distribution of the molecule in this mouse strain. The aim of this study was to investigate whether significant levels of trehalose reach the central nervous system of the SOD1G93A mouse after oral administration. This was performed by a trehalose assay of the brain of trehalose treated animals. A glucose assay was optimised for use in small samples of brain lysate after the digestion of trehalose into glucose by trehalase, and the difference in glucose concentration before and after digestion represented the trehalose level.

The aim of this study is to evaluate an alternative projection of the Medial Coronoid Process (MCP) of the canine elbow joint. The projection (Di35M-PrLO) was, to my knowledge, first mentioned in an article by Haudiquet et al in 2002. In that article the projection was tested in vitro, and a good sensitivity was showed for the Medial Coronoid Process. The projection might be helpful in cases of suspected Fragmented Coronoid Process (FCP) . This study is divided into three parts. The first part is an in-vivo test of the projection, including technique and subjective evaluation of the outlining of the MCP.

Bakgrund: Crohns sjukdom och ulcerös kolit är två huvudtyper som utmärker inflammatorisk tarmsjukdom. Inflammatorisk tarmsjukdom påverkar mag- och tarmkanalen och har ett oförutsägbart sjukdomsförlopp. Inflammatorisk tarmsjukdom debuterar vanligtvis i åldern 15-30 och kan ge ogynnsamma konsekvenser i personens dagliga aktiviteter eftersom han eller hon är upptagen med att exempelvis studera, skapa karriär eller bilda familj. Sjukdomarna har flera gemensamma särdrag där de förekommer i så kallade skov med perioder med försämring då tarmslemhinnan blir inflammerad och sårig, vilket leder till symtom som exempelvis blodiga eller slemmiga diarréer, viktnedgång, buksmärtor och trötthetSyfte: Syftet med uppsatsen är att beskriva konsekvenser av att leva med Crohns sjukdom eller Ulcerös kolit hos vuxna personer.Metod: En litteraturöversikt. En litteratursökning gjordes som ledde till sex granskade artiklar.

Volvo Human Monitoring (VHM) is an ongoing project at Volvo Cars where they measure, amongst other parameters, inhalation and exhalation through a device called Respiratory Inductance Plethysmograph (RIP), on drivers. RIP measures changes in the cross-sectional area of the chest and abdomen. When the driver is in motion, such as when she is turning the vehicle, the cross-sectional area changes and noise in the RIP signal may arise.The noise results in a large number of manual adjustments in the analysis of the RIP signal, which is very time consuming and the validity of the device for measuring inhalation and exhalation is questioned.The purpose of this study was to improve the efficiency of the analysis of the RIP signal. The goal was to create a new data processing tool in Matlab that automatically detects inhalation and exhalation from a RIP signal with higher validity compared to the previous data processing tool.In this study, nine tests were performed on drivers while they were driving in different scenarios such as highway, country road and in city traffic. Inhalation and exhalation was measured using a RIP, a pneumotachograph with a tightly sealed facemask and a thermocouple placed between the nose and mouth, which was used as reference to the RIP.The result of this study was a data processing tool that automatically detects inhalation and exhalation with higher validity compared to the previous data processing tool.

Vocal Cord Dysfunction (VCD) is characterized by paradoxical vocal cord movement during inspiration or expiration, and generally affects adolescents and predominantly women. Previous studies have shown a large inconsistency concerning terminology, definitions, etiology, assessment, differential diagnosis, co-morbidity and treatment. The purpose of this study was to map knowledge on and management of VCD in Sweden. The study was conducted as a written survey addressed to speech-language pathologists and physicians, and attained an answer percentage of 79 percent. The results showed that several professions were involved in the management of these patients, but no clear pattern of referral could be observed.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

ECG-Screening for young elite athletesAbstractBackgroundSudden cardiac death (SCD) during physical activity is a frightening and emotional tragedy that draws huge media attentions when it occurs. Fortunately it is a relatively uncommon occurrence but happens nonetheless to young athletes who often seems to be in perfect health. SCD is used as a term for sudden unexpected complications on the cardiovascular system that leads to a deadly outcome normally within the first hour of onset of symptoms and the cause is some sort of underlying cardiovascular disease that gets triggered by physical activity.Normally athletes gets divided into two groups dependent on age, over and under 35 years, and this studies focus is on the younger group since it is often during this period athletes are at the elite level. It is also in this category the most unexpected sudden deaths occur that is not due to coronary atherosclerosis, which is the dominant cause of death, and drastically increases, for people over 35 years old.AimThe aim of this study was to scientific and unbiased analyze peer-reviewed clinical articles todescribe the pros, cons and cost to implement an ECG-screening as a standard before physicalactivities for specifically defined elite athletes.MethodA systematic review was performed and after all data collection 21 articles was chosen to beused as a base for both background and analyze. At the end 10 articles was fulfilling the criteria to be used at the analyze and later the results.ResultsThe implementation of ECG-screening has reduced SCD in Italy by 89 % between the years 1979-2004.

This study examines if the prediction of cardiovascular disease in hypertensive patients can be improved upon when renal function and microalbuminuria are added to the classical risk factors The predictive capability of a model is measured by discrimination, calibration, reclassification and Harrell's C.The results are ambigious. In most cases, microalbuminuria should be included in the model, but the results regarding the other measures of renal function are varied. Therefore, the selection of risk factors to include in the model depends on which measure of prediction one prioritizes..

Touch that is performed in a sensitive and gentle way can be a good complement in caring. To be stricken with illness can involve that the individual feels powerlessness and to have no control over the own body. This could lead to both psychical and physical suffering. To strength health is one of the nurses' responsibilities and to touch can be one way. The aim of the study was to describe patients' experience of the effects of touch.

Interaktioner mellan vilda herbivorer och nötboskap är väldigt komplexa. Bland nackdelarna väger överföring av sjukdomar tyngst. Uppskattningsvis har cirka 70 % av alla sjukdomar hos boskap (inklusive zoonoser) som uppkommit på senare tid sitt ursprung hos vilda djur. Sjukdomar kan spridas via direkta kontakter eller indirekta interaktioner (luft, kroppsvätskor, avföring, kött eller mjölk) mellan vilda djur och boskap. Några exempel på sådana sjukdomar är: East Coast Fever, Corridor disease, January disease, katarralfeber, trypanosomos samt mul- och klövsjuka.

Aphasia is a disease that brings on disability. The purpose of the study is to describe the daily life when afflicted with aphasia and gain a deeper understanding of persons with aphasia in working ages. The study was made with a qualitative approach with a combination of data sources; literature, internet lectures, live lectures, interviews with personnel in medical and educational services and three persons with aphasia. More research in aphasiology is welcome. This may be aimed at developing knowledge about the importance of communication, of active participation in the social environment, and the achievement of improved attitudes towards people with disabilities. The study should give rehabilitation actors and close relations knowledge and support in their action when they meet people with aphasia..

Malt lymphoma is a malignant disease that can arise in a variety of extra nodal sites. Previous studies indicate that tumour arise from more mature B-cells.Our purpose was to examine the presence of clonality and somatic hypermutation of immunoglobulin (IgV?) of MALT lymphomas.Paraffin-embedded tumour samples from13 MALT lymphoma were subjected to rearrangement analysis, by using PCR, heteroduplex gels and sequence analysis.Successful amplification was seen in 10/13 cases and sequences of IgV? genes were obtained in 6/13, all of them were mutated. The percentage of mutation compared to germline sequences was 1,1% to 8,6% monoclonal rearrangemang. It was demonstrated that 5 of 7 clones were derived from the V?3 family, 2 from V?1 and 1 from the V? 4 family..

This article presents a survey of male dogs treated with the gonadotropin releasing hormone (GnRH) agonist deslorelin (Suprelorin®, Virbac) at three animal clinics in central Sweden. Filled-in questionnaires from 110 dogs were received. The paper also includes a review of existing litterature concerning reproduction in male dogs, focusing on endocrinology, the effects of gonadectomy and the GnRH agonist deslorelin. Continuous treatment with deslorelin produces infertility in male dogs. The pituitary is initially stimulated by deslorelin leading to a rise in luteinizing hormone (LH) and follicle stimulating hormone (FSH) secretion. As a consequence the testosterone levels also increase temporarily.