Platelets are small fragments, but they are of crucial importance for the coagulation. The risk of spontaneous bleeding increases when the level of platelets falls below a thrombocyte particle concentration threshold value of 50 x 109/L. In those cases a platelet transfusion might be compulsory. Ongoing research tries to improve the quality of the platelets and to increase the safety of the method used. However, we still need to better understand which factors that affect how patients react upon platelet transfusion.

AbstractAim of the study: Aim of the study was to investigate whether there were any connections in time between different parts of care in patients with cardiac arrest and hypothermia treatment and cognitive and physical function six months after cardiac arrest and to investigate neurological outcome related to primary registered cardiac arrest rhythm after six months and if there were any changes in cognitive and physical functions as well as self-related health between discharge from hospital and six months after cardiac arrest.Method: The study included 39 patients admitted to three Swedish hospitals between 2008-2011. Cognitive and physical function was evaluated with Cerebral Performance Cathegory, CPC completed with Mini Mental State Examination, MMSE for cognitive function and Bartels Index, BI for physical function and Euroqol-VAS for evaluating the self-related health.Result:  A significant connection was shown between time to start hypothermia treatment and BI, patients with longer time showed improved physical function after six months.Majority of the participants (66,7 %) had Ventricular fibrillation/Ventricular tachycardia, VF /VT, as primary registered cardiac arrest rhythm and in this group CPC and BI was significant better compared with the asystole /Pulsless Electrical Aktivity, PEA group.CPC, MMSE, BI and Euroqol-VAS were all improved over time.Conclusion: Participants with VF /VT as primary registered cardias arrest rhythm had significant better cognitive and physical function 6 months after hypothermia-treated cardiac arrest compared with participants with asystole/PEA as primary registered rhythm. This shows the importance of access to defibrillators in public places in the society and in hospitals and optimal education of lay people and medical staff. Cognitive and physical function and self-rated health improves over time, which might be a very important reason to convey patients, relatives and medical staff to continue cognitive and physical rehabilitation. Keywords: Cardiac arrest, hypothermia, cognitive and physical function, wellbeeing.

The purpose of the study was to review the current veterinary literature regarding gastric dilatation and volvulus (GDV) considering pathophysiology and treatment, and to evaluate the operative technique (incisional gastropexy) used during the years 2005 and 2006 at the University Animal Hospital (Universitetsdjursjukhuset), SLU, Uppsala, Sweden. GDV has a complicated pathophysiology which foremost effects the circulatory system. Progress is often acute and it is not unusual that patients are affected with shock. The initial treatment targets to alleviate the shock by fluid therapy and decompression of the stomach. There is a high risk of recurrence in the long term perspective unless the stomach is surgically fixated by gastropexy. The study describes two different techniques for gastropexy; incisional gastropexy, and funduspexy. Long term complications were rare among the patients that were treated surgically, while about half out of the eighteen dogs that undergo surgery do experience complications of various severity in the short term..

The ability to detect protein-based biomarkers, which are linked to different diseases like colorectal cancer, is very important as a diagnostic tool. Usually complex biological samples like blood are studied which will contribute to different technical issues when performing an assay. The aim with the project is to optimize and develop the high throughput protein detection technique Proximity Extension Assay, PEA, into a 96-plex panel, in hopes of discovering an expression profile for colorectal cancer. PEA was developed by Olink Bioscience and allows specific proteins in a sample to be quantitatively transformed into nucleic acid sequences that are subsequently detected and quantified with real-time PCR. Two proximity probes containing oligonucleotide sequences bind pairwise to target protein and when brought in proximity, a DNA polymerase will extend a hybridization arm from one probe over to the second forming a double-stranded DNA sequence that can serve as a template in real-time PCR.

The health care formulation of the principle of autonomy can be expressed as follows; ?you shall not treat a patient without the informed consent of the patient, or his or her lawfulsurrogate, except in narrowly defined emergencies?. The principle of beneficence refers to a moral obligation to act for the benefit of others. In heath care, the good or benefit in question is the restoration of the health of the patient. In fulfilling this obligation of beneficence, the physician sometimes intentionally overrides the patient?s preferences or actions for the purpose of benefiting the patient.

Background: Men that have gone through treatment for prostate cancer may lose their sexuality as result of treatment. The sexual ability might symbolize manliness, despite age and sexual activities. Aim: The aim of the literature study was to describe; Influence on sexuality and the daily life for men with prostatecancer and their experience of informationneeds. Method: The material for the literature study was searched through databases; 13 scientific articles were selected and two articles through manual search, all 15 articles were examined. Result: Five categories were found in the result of the literature study; physical dimension, emotional/mental dimension, social/practical dimension and informationneeds.

ABSTRACTThe aim of this study was to describe various methods of treatment and effects of treatment of ADHD, and to investigate wheater there is an association between adults with ADHD and obesity. Method:  Literature review. Twelve quantitative scientific articles were found in the data bases PubMed, Cinahl and MedLine.  Result: ADHD is a cognitive impairment that can lead to serious complications such as obesity. Studies show that drug treatments of adults with ADHD have positive effects in terms of reduced symptoms, increased efficiency and improved quality of life, but drugs can also cause side effects in form of loss of appetite and insomnia. For adults with ADHD and obesity drugs that affect metabolism have a significant impact on patients ability to lose weight.

Bakgrund: Övervikt och fetma är en global epidemi. Fetma kan orsakas av arv, miljö och beteendemässiga faktorer. Övervikt kanleda till flera följdsjukdomar. Viktminskning kan ge ökad livskvalité pch psykiskt välbefinnande. Ur ett hälsoekonomiskt perspektiv är det av vikt att det hälsofrämjande arbetet startar tidigt i barndomen.

Backgrund: Cancer är en av Sveriges och världens vanligaste folksjukdomar. När sjukdomen inte längre går att bota övergår vården från kurativ till palliativ vård. En del av patienterna i livet slutskede väljer att vårdas i hemmet och detta utgör en känslig period för både patienten och närstående. Närstående och familjemedlemmar vårdar och utför omvårdnadsuppgifter som annars skulle utföras av vårdpersonal. För att kunna utföra vården har närstående och anhörigvårdare stor behov av stöd.

Smärtlindring av cancersjuka är ett komplext och mångfacetterat område då cancer inte bara drabbar kroppen utan även själen. För att sjuksköterskan skall kunna smärtlindra patienter på ett så effektivt sätt som möjligt måste eventuella barriärer forceras genom pedagogik. Tio vetenskapliga artiklar har använts i denna litteraturstudie för att kartlägga en del av de barriärer en sjuksköterska kan stöta på i sitt pedagogiska arbete vid smärtlindring av cancersjuka, samt på vilka sätt dessa kan forceras. Resultatet visade att för att sjuksköterskan ska kunna fungera som pedagog i omvårdnaden av patienter så måste han/hon ha goda baskunskaper samt förmågan att se vilka kunskapsbehov som finns hos patienten. Resultatet visar även vikten av att patienten har god kunskap om farmakologisk smärtlindring..

Background: The Swedish population is aging [1] and malnutrition is a common problem among elderly people [2]. A method called food registration is used to monitor the patients? nutritional intake, with the purpose of reducing the risk of patients deteriorating in nutritional status during hospitalisation. However, the current method is not satisfactory and many food registration lists are incomplete. [3-6] Thus, patients do not receive a qualitative nutritional care since the assessment of the patients? nutritional status is based on incomplete documentation.Purpose: The purpose of this master thesis is to increase the quality in the nutrition monitoring process in the geriatric units B72 and B74 at Karolinska University Hospital in Huddinge, Sweden.

Feelings the nurses and the students experience in their encounter with death and dying patients..

The prehospital management of patients with acute myocardial infarction (AMI)now includes 12-lead electrocardiogram transmission directly from the ambulance to hospital.If the ECG shows ST-elevated myocardial infarction the patient should be transported directlyto a hospital with capability for percutaneous coronary intervention (PCI).                                               Aim: The aim of this study was to describe how ambulance nurses experienced the prehospital management of patients with AMI who are transported by ambulance directly to hospital for PCI.                                                Method: Semi structured interviews were conducted with eight ambulance nurses. Data were analysed using qualitative content analysis. The categories that emerged were: Use ofcompetence, Responsibility and Insufficiency. Result: The result showed that the ambulance nurses felt secure when they cared for patients transported directly to PCI. The nurses assessed the patient and decided how he or she should be cared for.

Bakgrund: Förekomsten av diabetes typ 2 ökar ständigt och undervisning med patienter är betydelsefullt i sjuksköterskors omvårdnadsarbete. Undervisning kan dock upplevas mer blockerande än stödjande. Syfte: Att beskriva sjuksköterskors stöd i undervisningen angående förändring av kost- och motionsvanor hos patienter med diabetes typ 2. Metod: En litteraturstudie har gjorts baserad på åtta vetenskapliga artiklar. Resultat: Bemötande och identifiera behov; empati, respekt och engagemang samt att vara insatt i var patienter befinner sig i förändringsprocessen förbättrar möjligheterna att påverka.

BackgroundAnorexia nervosa is a growing problem in society and it is most common among women. It is a complex disease that affects both the mental and the physical health. The disease expresses itself differently from person to person, therefore, treatment should be individualized. Nurses need to gain insight into how patients feel about the treatment in order to understand their experience. Previous studies use statistical research to evaluate treatment.