Aortic insufficiency is a very common valve problem in horses and most often affects older individuals, but nevertheless existent within younger ones. The root cause for aortic insufficiency can be varied, for example; endocarditis, ventricular septum defect or congenital valve disease but the most common are progressive valve degeneration or elite competition. Depending on the root cause, different changes can be observed on the aorta valves, but they do all have the same effect, the valves do not seal properly and blood leaks backwards. Many horses can, even with this deficiency, perform highly without any visible impacts and there is therefore no need to treat those subjects. Most often the symptoms arise at a later stage in life and they are, more often than none, put down for other reasons. In the occurrence of the clinical symptoms showing, treatment guideline is to inhibit these symptoms since the valve degeneration is presently irreversible.

Equine cutaneous melanomas arise much more often in horses with a grey coat color than in horses of other colors. Some scientists have in different studies come to the conclusion that the melanomas are neoplasms which can be classified by examining their histological and macroscopic features. The more defined and demarcated a tumor is, the more benign it tends to be. Other scientists believe that the skin lesions are the result of a pigmentation disorder that is linked to the greying of the coat color. According to this theory, the lesions are not malignant although they have the ability to metastasize.

Dilated cardiomyopathy (DCM) is the second most common heart disease in dogs. Since the disease is seen more frequently in certain breeds, among them Newfoundland dogs, a genetic factor is suspected. This study was partly undertaken to investigate whether there is a significant sex predilection regarding DCM. Moreover, the difference in mean age of death between male dogs and females with DCM was investigated, as well as males and females dying from DCM compared to dying from other reasons (i.e. without DCM).

SAMMANFATTNINGNatriuretiska peptider är en är en grupp proteiner som via natriuretiska, diuretiska och vasodilaterande egenskaper reglerar vätskehomeostasen i kroppen (Levin et al, 1998). De frisätts bland annat när hjärtmuskelcellerna utsätts för stress och kan fungera som biomarkör för att utvärdera hjärtsjukdom. Analysering av typ B natriuretic peptide (BNP) i blod kan komma att vara till hjälp för den praktiserande veterinären vid diagnostisering av hjärtsvikt och även vid uppskattning av grad av hjärtsjukdom. Det har även visat sig att BNP kan användas för att uppskatta prognosen hos hundar med kronisk klaffdegeneration (Chetboul et al, 2009; Moonarmart et al, 2010).Kronisk klaffdegeneration är den vanligaste hjärtsjukdomarna hos hund och drabbar fram för allt små till medelstora hundar från medelåldern och uppåt (Kogure, 1980). Atrioventrikulärklaffarna, vanligtvis mitralis, blir nodulärt förtjockade med inlagring av glukosaminoglykaner och fibrosvävnad vilket leder till klaffinsufficiens.

Background: There are many people waiting for a kidney transplant. To get a kidney from a living donor has many advantages. The gift is about giving and receiving. The decision is characterized by life-philosophy of the donor.Aim: To highlight the experiences of the kidney donation process.Methods: A systematic literature review in which 11 articles were included, seven qualitative and four quantitative. The articles are quality and ethically reviewed, the results are analyzed according Granskär & Höglund and Polit & Beck.Results: The results were gathered under two themes: the decision-process shows the path from idea to decision and implementation-process treats the donation and confirmation of the gift.

Previous studies have shown positive results on the use of music as postoperative pain relief. Quantitative studies have examined the effect of music on rated pain and otherparameters such as anxiety, relaxation and blood-pressure. The purpose of this study was to investigate the expectations and experiences of patients and nurses onimplementing music as postoperative pain relief in an orthopedic unitQualitative design and semi-structured interviews were used to examine expectations and experiences. Five patients and five nurses in the unit were interviewed.Four themes developed during the data-analysis. These themes were ?Expectations on music as postoperative pain relief?, ?Experiences of music as postoperative pain relief?,?Effects of music as postoperative pain relief? and ?Continued implementation of musicas postoperative pain relief?.

This essay will focus on video and computer game violence. We hope to uncover, with the help of semiotics, according to Barthes design, if this kind of violence can have a negative effect on youth and adolescents. How intense is the violence and how graphic is it?. PEGI is the European measurement for game age limits.

Hepatitis E virus, HEV, is a frequent causative agent behind, especially waterborne, infections in developing countries such as India. However, during the last years the number of non-travel-associated infections in industrialised countries, for example US, Germany and Sweden, has increased. The symptoms vary from mild with nausea to icterus and it can even be lethal. There are four different genotypes of HEV and many studies consider HEV infection to be a zoonosis. Scientists have by using phylogenetic analyses found great genetic similarity between strains isolated from humans, pigs and food, such as pork and liver, especially among viruses belonging to genotype 3.

The RECK gene is a relatively new discovered gene with important implications for cancer research. The research has been primarily concentrated on the human gene with the ultimate aim to identify the invasive characteristics. Up regulated RECK is linked to significantly prolonged survival rates in patients with severe forms of malignancies. RECK is normally expressed in all cells of the body and has an important role in the balance between destructive and constructive features of the extracellular matrix. The RECK protein is a membrane-bound glycoprotein that inhibit matrix metalloproteinases which has the function of breaking down the ECM. There is a significant correlation between RECK gene expression and the formation of new vessels, presumably via the mediation of VEGF which is an important and powerful inducer of angiogenesis.

The aim of this study was to find possible relations between behaviour and physiology for puppies during different parts of a puppy test. This work deals mainly with the physiological part of the study. Thirtysix puppies, från five litters, were tested in a behaviour test where heart rate was measured and saliva samples were collected before and after each part in the test. Saliva and urine samples were analyzed for corisol concentration as an indicatior of stress. The tests were performed during two consecutive days in the breeders' home when the puppies were seven weeks old. In addition, heart rate and cortisol levels were also measured in the bitch since we were interested in finding out if there were any relations between physiological levels in bitches and puppies.

Sjuksköterskor har flera arbetsuppgifter som innebär en möjlig kontakt med patienters blod och risk för en blodsmitta. Enligt föreskrifter från Arbetsstyrelsen ska handskar användas av vårdpersonal för att förebygga smitta. Trots dessa föreskrifter varierar användningen av handskar bland sjuksköterskor. Syftet med denna studie var att undersöka sjuksköterskors attityder till att använda handskar i vården där risk för blodsmitta kan förekomma. En empirisk studie med kvalitativ ansats genomfördes.

Every year about 30000 people have a stroke. It is caused by either a bleeding or a blood clot, and depending on where the damage is, the patient can get different types of difficulties following after the stroke. About 40 % of all stroke patients sufferfrom some kind of speech and/or communication difficulty, like aphasia or dysarthria. As hospital staff it´s important to know how to communicate with these people, to get a deeper understanding regards their needs.Aim:The aim of this study is to out of a patient's perspectivedescribeexperiences ofcommunication difficulties that can follow after a stroke.Method:A content analysis with a qualitative approach was used to analyse five autobiographies.Results:The result showed in what way stroke patients experienced their communication difficulties, and how they felt about the hospital staffs treatment related to their communication difficulties. During the analysis two major themes emerged: suffering and wellbeing.

The objectives of this study was to examine the prevalence of hypertrophic cardiomyopathy in a family of British Shorthaircats to determine the mode of inheritance and to investigate if the disease was associated with a mutation in myosin binding proteinC (MyBPC3). The family comprised 28 cats, seven male and 21 females. The cats underwent a physical examination, including cardiac auscultation, and an ultrasound examination. Blood was collected for DNA- analysis. The blodsamples were sent in a buffer solution to Kathryn Meurs, Washington State University, USA for analysis, where the genes coding for MyBPC, Troponin I and T were characterized using microsequencing technique. Out of the 28 cats, 8 were diagnosed with HCM, 2 were diagnosed with congenital heart disease but had no evidence of HCM.

Abstract      Background: Stroke, caused by a blood clot or a bleeding in the brain, is one of the large endemic diseases in Sweden. The symptoms are very individual and depend on where the stroke is located. The nurse is a key person due to the importance to individualize the rehabilitation of the patient. The consequences after a stroke are not only visible functions reductions but also cognitive and practical problems. Stroke often leads to extensive changes in life, and individuals who get a stroke have to adjust their daily life. Aim: The aim of the study was to describe individuals? experiences of changes in daily life, one year or more after a stroke. Method: An inductive, qualitative approach was used.

Hypertoni är vanligt förekommande i dagens samhälle och anses därför ha blivit en folksjukdom. Uppskattningsvis har 1,8 miljoner av Sveriges vuxna befolkning hypertoni. Hypertoni står för cirka 13 procent av den totala dödligheten i världen, och ses som en riskfaktor till ett stort antal hjärt- och kärlsjukdomar. Idag finns det internationella riktlinjer för vård av hypertoni i bland annat England och USA. Dock saknas det specifika svenska riktlinjer för vård av hypertoni.